2017
DOI: 10.1016/j.rbre.2016.09.014
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Abstract: Supplementation with omega-3 had no impact on serum concentrations of IL-6, IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol.

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Cited by 17 publications
(10 citation statements)
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“…In line with our study, Agh et al (2017) showed that omega-3 fatty acids supplementation (720 mg of EPA + 480 mg of DHA) for 8 weeks decreased serum FIGURE 1 Summary of patient flow diagram hs-CRP levels in patients with CAD (Agh et al, 2017). In another study, omega-3 fatty acids supplementation (1,080 mg of EPA + 200 mg of DHA) for 12 weeks was effective for reducing CRP levels in women with systemic lupus erythematosus and low disease activity, though had no impact on circulating interleukin 6, interleukin 10, leptin, and adiponectin (Borges et al, 2016). Our previous study documented that omega-3 fatty acids supplementation from flaxseed oil at a dosage of 2 g/day for 12 weeks significantly decreased serum hs-CRP, while increased plasma TAC and GSH in diabetic patients with foot ulcer (Soleimani, Hashemdokht, et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…In line with our study, Agh et al (2017) showed that omega-3 fatty acids supplementation (720 mg of EPA + 480 mg of DHA) for 8 weeks decreased serum FIGURE 1 Summary of patient flow diagram hs-CRP levels in patients with CAD (Agh et al, 2017). In another study, omega-3 fatty acids supplementation (1,080 mg of EPA + 200 mg of DHA) for 12 weeks was effective for reducing CRP levels in women with systemic lupus erythematosus and low disease activity, though had no impact on circulating interleukin 6, interleukin 10, leptin, and adiponectin (Borges et al, 2016). Our previous study documented that omega-3 fatty acids supplementation from flaxseed oil at a dosage of 2 g/day for 12 weeks significantly decreased serum hs-CRP, while increased plasma TAC and GSH in diabetic patients with foot ulcer (Soleimani, Hashemdokht, et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…However, subclinical inflammation assessed by variations of serum CRP levels in predominantly ‘normal’ ranges have previously been linked to relevant clinical parameters such as disease activity and surrogate markers for atherosclerosis in SLE patients. 17,19 Previous interventional studies which administered omega-3 PUFA containing fish oil to SLE patients produced conflicting results in this regard: amelioration of systemic inflammatory markers was seen in some 20,21 but not all studies. 22,23 Of note, individual nutrition status omega-3 PUFA content in the blood cells was not assessed in these studies.…”
Section: Discussionmentioning
confidence: 99%
“…The association between intake of omega-3 fatty acid supplements and inflammation has been studied in several cohorts, but the results have been conflicting. Omega-3 fatty acid supplementation has been found to reduce inflammatory biomarkers in populations with various chronic inflammatory or non-inflammatory diseases [ 10 , 18 , 19 ]. Importantly, the Vitamin D and Omega-3 trial (VITAL) found no decrease in inflammatory markers in subjects that used either 1 g omega-3 or 50 μg vitamin D daily for 1 year [ 20 ].…”
Section: Discussionmentioning
confidence: 99%