D engue is among the most important arboviral diseases worldwide; it is reported in 128 countries with an estimated 50 million to 100 million cases annually. 1 It represents a major public health problem in Paraguay. Dengue virus (DENV) infections may result in subclinical illness or evolve to a potentially fatal disease, known as severe dengue. Studies indicate that DENV infections can trigger a flare of systemic lupus erythematosus (SLE) and that co-occurrence can lead to severe cases. [2][3][4] The purpose of this report is to present a case of a patient with SLE and a delayed diagnosis of dengue.