Dismenorreia primária: tratamento

Obstetrícia, Federação Brasileira das Associações de Ginecologia e

doi:10.1016/j.ramb.2012.05.001

Cited by 6 publications

(3 citation statements)

References 30 publications

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“… 5 Among them, NSAIDs are the first-line treatment. 6 There are many types of NSAIDs which are widely used as analgesics and anti-inflammatory agent through inhibiting cyclooxygenase (COX) enzymes including COX-1 and COX-2. The pain relieve ability of NSAIDs is mainly attributed to COX-2 enzymes inhibition—an important pathway related to hormone release and the process of inflammation, while their adverse effects (such as indigestion, headaches, and lethargy, which are considered to be the most concerning adverse effects in PD patients) are thought to be involved with the COX-1 enzymes inhibition.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis

Feng

Wang

2018

Mol Pain

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ObjectiveNon-steroidal anti-inflammatory drugs are used as first-line treatment of primary dysmenorrhea, but there has been no optimal clinical choice among non-steroidal anti-inflammatory drugs yet. The present study was to assess the relative benefits of different common non-steroidal anti-inflammatory drugs for primary dysmenorrhea patients with a network meta-analysis.MethodsRandomized controlled trials were screened by our criteria and included in the network meta-analysis. Pain relief was considered as primary outcomes and adverse effect was supplied as a safety outcome, while additional rescue, assessment score, and pain intensity difference were secondary outcomes. All the indexes were evaluated with odds ratio or standardized mean difference. Surface under cumulative ranking curve result was used to calculate the ranking of each treatment.ResultsTotally, 72 randomized controlled trials of 5723 patients and 13 drugs were included in our study after screening. As for pain relief, all drugs except nimesulide, rofecoxib, and waldecoxib were superior to aspirin (odds ratio with 95% credible intervals, diclofenac: 0.28 (0.08, 0.86), flurbiprofen: 0.10 (0.03, 0.29), ibuprofen: 0.32 (0.14, 0.73), indomethacin: 0.21 (0.07, 0.58), ketoprofen: 0.25 (0.10, 0.64), mefenamic acid: 0.28 (0.09, 0.87), naproxen: 0.31 (0.15, 0.64), piroxicam: 0.15 (0.03, 0.59), and tiaprofenic acid: 0.17 (0.04, 0.63)). Aspirin also required additional rescue when compared with the majority of other drugs (flurbiprofen: 3.46 (1.15, 11.25), ibuprofen: 6.30 (2.08, 20.09), mefenamic acid: 7.32 (1.51, 37.71), naproxen: 2.66 (1.17, 6.55), and tiaprofenic acid: 9.58 (1.43, 94.63)). As for assessment of the whole treatment, ketoprofen, naproxen, rofecoxib, and ibuprofen got higher score significantly than placebo. In addition, ibuprofen performed better than placebo in pain intensity difference. Considering the safety, tiaprofenic acid and mefenamic acid were noticeable in low risk, and indomethacin revealed higher risk than any other drugs. According to the results of network analysis and surface under cumulative ranking curve, flurbiprofen was considered to be the best one among all the treatments in efficacy, and aspirin was worse than most of others. On the other hand, tiaprofenic acid and mefenamic acid were indicated as the safest drugs.ConclusionConsidering the efficacy and safety, we recommended flurbiprofen and tiaprofenic acid as the optimal treatments for primary dysmenorrhea.

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Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis

Feng

Wang

2018

Mol Pain

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“…The first line of therapy for PD is nonsteroidal anti-inflammatory drugs (NSAIDs). [15] 17% to 95% (mean 67%) of women relieve pain with NSAIDs. [16] At present, the main side effects of NSAIDs are the renal disturbances, gastrointestinal complications, and cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chinese herbal medicine on primary dysmenorrhea

Xie

Shen

et al. 2019

Medicine

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“…Nowadays, nonsteroid anti-inflammatory drug (NSAIDs), like Ibuprofen, indomethacin, and chlorine acid, is the first-line drugs for the treatment of primary dysmenorrhea [ 6 ], which is to reduce the accumulation of prostaglandin and then alleviate spasmodic contraction of the uterus caused by prostaglandins, by inhibiting the COX-2 enzymes activity [ 7 ]. But at the same time COX-1 would also be inhibited and then causes adverse reactions such as nausea, diarrhea, and headache [ 8 ]. Recent studies have shown that cardiovascular and cerebrovascular diseases would also be induced through chronic use of these drugs, such as unstable angina, acute myocardial infarction, and venous thromboembolism [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics

Yang

Guo

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the efficacy and mechanism of primary dysmenorrhea patients were treated with herb-partitioned moxibustion through metabonomics. Methods. 20 patients with primary dysmenorrhea were randomized into two groups, separately treated with herb-partitioned moxibustion at CV8 (shenque) and acupuncture at SP6 (sanyinjiao). After three menstrual cycles' treatment, the intensity of menstrual pain using VAS and the changes of metabolites of plasma using LC-MS were observed. Results. The VAS of two groups decreased with different descending range. Herb-partitioned moxibustion upregulated 20α-dihydroprogesterone, pregnenolone, prostaglandin E2 and γ-aminobutyric acid and downregulated the content of estrone and prostaglandin H2, while acupuncture upregulated pregnenolone and 20α-dihydroprogesterone and downregulated 2-methoxyestradiol-3-methylether, 15-hydroxyeicosatrienoic acid and 6-keto-prostaglandin. Discussion. It was effective in relieving the abdominal pain by these two therapies. Herb-partitioned moxibustion is superior to acupuncture for primary dysmenorrhea, which could be related to regulating the endocrine hormone.

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Dismenorreia primária: tratamento

Cited by 6 publications

References 30 publications

Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis

Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis

Effect of Chinese herbal medicine on primary dysmenorrhea

Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics

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