2014
DOI: 10.1016/j.neuron.2014.06.016
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Abstract: SUMMARY The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month old mice exhibit an impairment of functional recovery after nerve injury compared to 2-month old animals. We find no difference in the intrinsic growth capacity between aged and young sensory neurons in vitro nor in their ability to activate growth-associated transcriptional programs after injury. Instead, using age-mismatched nerve transplants in vivo, we sho… Show more

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Cited by 215 publications
(198 citation statements)
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References 26 publications
(37 reference statements)
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“…Engaging several methods, we set out to comprehensively describe age‐dependent changes on functional, structural, cellular, and molecular levels. Our experimental design confirmed and further detailed previous work in this area (Figures 1 and 2) (He, Yadgarov, Sharif, & McCluskey, 2012; Painter et al, 2014; Scheib & Hoke, 2016; Verdu et al, 2000). …”
Section: Discussionsupporting
confidence: 89%
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“…Engaging several methods, we set out to comprehensively describe age‐dependent changes on functional, structural, cellular, and molecular levels. Our experimental design confirmed and further detailed previous work in this area (Figures 1 and 2) (He, Yadgarov, Sharif, & McCluskey, 2012; Painter et al, 2014; Scheib & Hoke, 2016; Verdu et al, 2000). …”
Section: Discussionsupporting
confidence: 89%
“…A growing body of work demonstrates age‐dependent decline of peripheral nerve regeneration capacity (Painter et al, 2014; Verdu et al, 2000; Wang et al, 2007), but insight into underlying mechanisms remains limited. To better understand age‐dependent factors impacting on peripheral nerve regeneration, we performed sciatic nerve crush injuries on C57BL/6 J mice of two different ages.…”
Section: Resultsmentioning
confidence: 99%
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“…The use of nerve conduits to bridge short or mid length gaps is a good alternative to autografts (Arslantunali et al, 2014), although regeneration is slowed during the initial phase compared to autograft (Boeckstyns et al, 2013). Several parameters affect the rate of axonal regeneration, including the distance between stumps (Scherman et al, 2001), the age of the subject (Kang et al, 2013;Painter et al, 2014;Verdú et al, 2008), the time after repair and the distance between the lesion site and end organ (Gordon et al, 2003). Indeed, the time from injury to target reinnervation is the most important predictor of the degree of functional recovery (Krarup et al, 2002), emphasizing that factors that control early axonal outgrowth influence the final level of recovery attained even years later.…”
Section: Introductionmentioning
confidence: 99%
“…The outcome depends on the injury type: Complete nerve transection has a worse outcome than nerve crush due to mis-directed axon growth, and proximal injuries also have a poorer outcome than distal ones due to the slow (1 mm/day) rate of axon regrowth (Fu and Gordon, 1995). In addition, aged Schwann cells are less supportive of axon outgrowth than young Schwann cells and might produce less efficiently beneficial growth and metabolic factors (Painter et al, 2014). Traumatic nerve injury is followed by stereotypic events called Wallerian degeneration, i.e.…”
Section: Nrg1 and Remyelination After Injurymentioning
confidence: 99%