Barium tungstate nanoparticles to enhance radiation therapy against cancer

Wang, Renjie; Cao, Zhengwei; Lan, Wei; Bai, Lin; Wang, Hui; Zhou, Shi-Yi; Zhan, Shuyue; Ji, Bin; Li, Zibo; Gao, Shi; Xie, Jin; Ma, Qingjie

doi:10.1016/j.nano.2020.102230

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Jo et al confirmed the radiosensitization effect of CaWO 4 NPs both in vitro (head and neck cancer cells) and in vivo (xenografts) [92]. Soon after, Wang et al found that BaWO 4 NPs also work as radiosensitizers, and they observed that compared with treatment with X-rays alone, incubation with PVP-coated CaWO 4 and BaWO 4 increased the level of intracellular 1 O 2 by 17 and 15% and the level of intracellular •OH by 9.8-and 6.4-fold, respectively, reflecting that the generation of 1 O 2 and •OH is a key factor in the radiosensitization of metal tungstates [93].…”

Section: Metal-based Semiconductorsmentioning

confidence: 99%

Promoting reactive oxygen species generation: a key strategy in nanosensitizer-mediated radiotherapy

Jia

Fan

et al. 2021

Nanomedicine

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The radiotherapy enhancement effect of numerous nanosensitizers is based on the excessive production of reactive oxygen species (ROS), and only a few systematic reviews have focused on the key strategy in nanosensitizer-mediated radiotherapy. To clarify the mechanism underlying this effect, it is necessary to understand the role of ROS in radiosensitization before clinical application. Thus, the source of ROS and their principle of tumor inhibition are first introduced. Then, nanomaterial-mediated ROS generation in radiotherapy is reviewed. The double-edged sword effect of ROS and the potential dangers they may pose to cancer patients are subsequently addressed. Finally, future perspectives regarding ROS-regulated nanosensitizer applications and development are discussed.

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Section: Metal-based Semiconductorsmentioning

confidence: 99%

Promoting reactive oxygen species generation: a key strategy in nanosensitizer-mediated radiotherapy

Jia

Fan

et al. 2021

Nanomedicine

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“…Various methods are performed to synthesize BaWO 4 nanostructures, such as hydrothermal/solvothermal, co-precipitation, solid-state reaction, polymeric precursor technique, cell electrochemical technique, molten salt technique, and microemulsion techniques . However, co-precipitation is one of the simple and environment-friendly techniques to synthesize nanoparticles because of its simple reproducibility, low cost, elevated yield, and product purity. , It is suitable for the synthesis of BaWO 4 under easygoing conditions (i.e., ambient temperature and pressure). A BaWO 4 nanostructure has been analyzed by diverse applications as it is an attractive material in the electro-optic industry .…”

Section: Introductionmentioning

confidence: 99%

“… 15 However, co-precipitation is one of the simple and environment-friendly techniques to synthesize nanoparticles because of its simple reproducibility, low cost, elevated yield, and product purity. 16 , 17 It is suitable for the synthesis of BaWO 4 under easygoing conditions (i.e., ambient temperature and pressure). A BaWO 4 nanostructure has been analyzed by diverse applications as it is an attractive material in the electro-optic industry.…”

Section: Introductionmentioning

confidence: 99%

Neodymium-Doped Novel Barium Tungstate Nanospindles for the Enhanced Oxygen Evolution Reaction

et al. 2023

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In this work, pristine, 0.02, 0.04, and 0.06 M neodymium (Nd)-doped barium tungstate nanostructures were synthesized via a simple co-precipitation method for the water oxidation process. The obtained X-ray diffraction high-intensity peak at a 2θ value of 26.4°corresponding to the (112) lattice plane confirmed the formation of a tetragonal structure of BaWO 4 . Moreover, the BaWO 4 morphology was examined by scanning electron microscopy, which showed the existence of nanospindles. An energydispersive X-ray spectrum confirmed the subsistence of the produced materials, for example, barium (Ba), tungsten (W), oxide (O), and neodymium (Nd), with weight percentages of 28.58, 46.63, 16.64, and 8.16%, respectively. The 0.04 M Nd-doped BaWO 4 product was explored to attain a high surface area of 18.18 m 2 /g, a pore volume of 0.079 cm 3 /g, and a pore diameter of 2.215 nm. Compared to the other prepared electrodes, the 0.04 M Nd-doped BaWO 4 product exhibited low overpotential values of 330 mV and 450 mV to deliver current densities of 10 mA/cm 2 and 50 mA/ cm 2 , respectively. In addition, the optimized electrode achieved a small Tafel slope value of 158 mV dec −1 and followed the Volmer− Heyrovsky mechanism. Moreover, the electrical conductivity of BaWO 4 was tuned due to the addition of a rare-earth metal dopant, and it exhibited the charge-transfer resistance and solution resistance values of 0.98 and 1.01 Ω, respectively. The prepared electrocatalyst was further studied by using cyclic voltammetry, and it exhibited a high double-layer capacitance value of 29.3 mF/ cm 2 and high electrochemically active surface areas of 1.465 cm 2 . The electrochemical performance was greatly improved depending on the concentration of the doping agent, and it was well consistent with the obtained results. The best electrocatalyst was subjected to a chronoamperometry test, which exhibited excellent stability even after 20 h. Hence, this work suggests that alkaline metal tungstates have a cost-effective, efficient, and promising electrocatalyst, and it is a new approach for the water oxidation process.

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“…They found a oneyear survival of 86% for mice treated with gold and irradiation versus 20% with x-rays alone and 0% with gold alone. An approach which was more comparable to the work of this thesis was presented by Wang et al, who used intratumorally applied barium tungstate nanoparticles (BaWO4) 129 . Due of the presence of tungsten, which is another heavy metal ion, the demonstrated effect cannot be solely based on barium.…”

Section: Comparison Of In Vitro and In Vivo Effectiveness Of Banps As...mentioning

confidence: 79%

Preclinical evaluation of nanoparticle enhanced breast cancer diagnosis and radiation therapy

Jonas¹

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Triple negative breast cancer (TNBC) is an aggressive type of cancer which makes up 15-20% of all newly diagnosed cases, lacking the main target molecules for tumor specific treatment.Surgery or systemic therapy by chemotherapy are frequently used in the clinic and combined with radiation therapy to improve locoregional control in breast cancer patients after surgery.With a poor prognosis, there is a clear need to explore new treatment options for TNBC. The aim of the here presented PhD project was to evaluate the feasibility to enhance the biological effect of radiation therapy and increase tumor contrast for diagnosis by applying an in vivo microCT imaging system in combination with barium nanoparticles (BaNPs) in a pH8N8 WAP-T-NP8 mouse model for TNBC. Characterization of the BaNPs revealed strong x-ray attenuation and no toxic effects in different cancer and normal cell lines. Furthermore, irradiation of cancer cells using low energy x-rays in the keV range by a microCT resulted in a significant reduction on colony formation capability. In vitro, this low energy irradiation effect on clonogenic tumor cell survival was enhanced in the presence of BaNPs. Next, a subcutaneous lung cancer mouse model in immunodeficient mice and an orthotopic syngeneic mouse model for breast cancer was applied for further in vivo evaluation. Once the treatment plan was optimized regarding the applied x-ray doses and the frequency of irradiation, low energy radiation therapy within a classical in vivo microCT significantly reduced tumor growth or even resulted in shrinkage of the tumors without visible side effects and weight loss in comparison to untreated controls. However, the intratumoral application of BaNPs was not able to increase the irradiation effect on tumor growth kinetics. This might be in part due to inhomogeneous distribution of BaNPs within the tumor observed by microCT imaging. K-edge subtraction imaging as well as x-ray fluorescence of explanted tumor samples confirmed these findings. To localize the BaNPs in 3D to specific sites within the tumor environment and to detect morphological alterations within the tumor due to irradiation in proximity to BaNPs an ex-vivo imaging based analytic platform was established, utilizing co-registration of microCT and histology data. This imaging approach co-localized BaNPs with CD68 positive phagocytic cells and revealed a non-uniform distribution of the BaNPs within the tumor, however with no signs of locally enhanced radiation effects. Furthermore, antibody functionalized BaNPs were generated for systemic application. Analysis of biodistribution revealed that EpCAM labeled BaNPs did not reach the tumor after intra-venous administration, but accumulated in liver and spleen, demonstrated by a strong CT contrast within these organs.

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Barium tungstate nanoparticles to enhance radiation therapy against cancer

Cited by 8 publications

References 32 publications

Promoting reactive oxygen species generation: a key strategy in nanosensitizer-mediated radiotherapy

Promoting reactive oxygen species generation: a key strategy in nanosensitizer-mediated radiotherapy

Neodymium-Doped Novel Barium Tungstate Nanospindles for the Enhanced Oxygen Evolution Reaction

Preclinical evaluation of nanoparticle enhanced breast cancer diagnosis and radiation therapy

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