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Cited by 91 publications
(80 citation statements)
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“…Due to its central function in the architecture of healthy epithelia, E-cadherin represents a highly attractive target for bacteria because it acts as a receptor for Listeria monocytogenes (20) or Streptococcus pneumoniae (21). However, it is unclear whether truncated E-cadherin can function as a receptor for bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…Due to its central function in the architecture of healthy epithelia, E-cadherin represents a highly attractive target for bacteria because it acts as a receptor for Listeria monocytogenes (20) or Streptococcus pneumoniae (21). However, it is unclear whether truncated E-cadherin can function as a receptor for bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…An adhesive function was also demonstrated for phosphorylcholine of the pneumococcal cell wall, which was shown to mediate internalization into endothelial cells via plateletactivating factor receptor (PAFr) (Cundell et al, 1995;Radin et al, 2005). The lipoprotein PsaA, which is part of an ABC transporter complex for manganese, is thought to interact specifically with Ecadherin (Anderton et al, 2007). In addition, a subclass of pneumococcal strains produces pili, which promote bacterial adherence to host cells (Barocchi et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…For example, pneumococcal surface protein C (PspC) is a multifunctional choline-binding protein and a major virulence factorof pneumococci that interacts directly and in a human-specific manner with the polymeric immunoglobulin receptor, and mediates pneumococcal adherence and invasion of host cells (10 -12). In addition, lipoproteins such as ABC metal permease PsaA (13), a pathogenicity-island encoded protein PsrP (14,15) and pili, expressed by a subclass of pneumococci (16,17) have been suggested to have adhesive functions. Furthermore, a number of pneumococcal proteins interacts with fibronectin or plasminogen, a strategy commonly employed by many invading pathogens to colonize or disseminate within the host (18,19).…”
mentioning
confidence: 99%