2008
DOI: 10.1016/j.mcn.2008.01.013
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Abstract: The extracellular matrix (ECM) is an important regulator of angiogenesis and vascular remodeling. We showed previously that angiogenic capillaries in the developing CNS express high levels of fibronectin and its receptor α5β1 integrin, and that this expression is developmentally downregulated. As cerebral hypoxia leads to an angiogenic response, we sought to determine whether angiogenic vessels in the adult CNS re-express fibronectin and the α5β1 integrin. Ten-week old mice were subject to hypobaric hypoxia fo… Show more

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Cited by 96 publications
(129 citation statements)
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References 67 publications
(104 reference statements)
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“…8,9 Upregulation of angiopoietin-2, fibronectin, and a5b1 integrin was also observed in cortical vascular endothelial cells after exposure to chronic hypoxia. 10,11 In accordance with these molecular events, an increase in microvascular density was shown in rats and mice exposed to chronic hypoxia. 12,13 Furthermore, a recent in vivo microscopic study has revealed that the brain microvasculature has morphologic 'plasticity' that promote cerebral angiogenesis in adult mice.…”
Section: Introductionmentioning
confidence: 72%
“…8,9 Upregulation of angiopoietin-2, fibronectin, and a5b1 integrin was also observed in cortical vascular endothelial cells after exposure to chronic hypoxia. 10,11 In accordance with these molecular events, an increase in microvascular density was shown in rats and mice exposed to chronic hypoxia. 12,13 Furthermore, a recent in vivo microscopic study has revealed that the brain microvasculature has morphologic 'plasticity' that promote cerebral angiogenesis in adult mice.…”
Section: Introductionmentioning
confidence: 72%
“…In contrast, Opc primarily binds to ECM proteins, such as fibronectin and vitronectin, and is particularly implicated in host cell invasion of endothelial cells [73]. Expression of fibronectin and its major receptor, a5b1 integrin, is enhanced during cerebral hypoxia, and therefore, may predispose the host to meningococcal meningitis [74] (Fig. 2).…”
Section: Central Nervous Systemmentioning
confidence: 99%
“…Hypoxia stimulates the production of galectin-1, a lactose-binding lectin, which enhances cell-to-ECM adhesion and contributes through this mechanism to hypoxia-induced pulmonary hypertension in mice (Case et al, 2007). Hypoxia facilitates the production of fibronectin in brain capillaries, in parallel with overexpression of integrin a5b1 (Milner et al, 2008). In this context, hypoxemia operates through HIF (Hypoxia Inducible Factor) transcription factor (Myllyharju and Schipani, 2010).…”
Section: Impact Of Hypoxia On Ecm Remodelingmentioning
confidence: 99%
“…For example, hypoxia enhances b1 expression through a HIFamediates transcriptional mechanism in fibroblasts , a5b1 in endothelial cells (Milner et al, 2008), avb3 in placenta (Cowden Dahl et al, 2005), b2 in leukocytes (Kong et al, 2004), or avb5 in endothelial cells (Walton et al, 2000). HIF was also found to control the expression of NEDD9 in colorectal carcinoma cells (Kim et al 2010).…”
Section: Impact Of Hypoxia On Integrin Expression and Functionmentioning
confidence: 99%