New insights on the effects of endocrine-disrupting chemicals on children

Predieri, Barbara; Alves, Crésio

doi:10.1016/j.jped.2021.11.003

Cited by 25 publications

(11 citation statements)

References 78 publications

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“…Action mechanisms of EDCs comprise estrogenicity, androgenicity, thyroid change, hormone receptors' transformation, retinoic acid alteration, change of target tissues, pancreatic beta-cell disorder, inhibition of hormone metabolism, and modifying effects of hormones (55). EDCs tend to regulate the levels of endogenous hormones by disrupting synthesis, secretion, transport, action, and degradation through mechanisms concerning the identical hormone receptors and signaling pathways (2). These chemicals can bind to receptors to imitate endogenous hormones, and they act by changing hormone signaling through different means (56).…”

Section: Discussionmentioning

confidence: 99%

“…Pesticides are included as thyroid disruptors that affect the hypothalamus/ pituitary/thyroid axis (12). The identification of EDCs in a human body can be performed by collecting serum, urine, and breast milk for analysis at a laboratory even though quantifying the results is not easy (2).…”

Section: Discussionmentioning

confidence: 99%

“…Agrochemicals are various types of chemical substances applied extensively in agriculture for many purposes, namely to control different insects using insecticides, destroy weeds and unwanted plants with herbicides, prevent fungal growth through fungicide application, control rodents such as mice and rats using rodenticides, and to increase agricultural productivity (1)(2). All human populations in the world are not completely free from exposure to pesticides that lead to the occurrence of either acute or chronic diseases (3).…”

Section: Introductionmentioning

confidence: 99%

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Pesticides Exposure and Thyroid Hormone Levels Among Agricultural Workers and Pesticide Applicators: A Systematic Review

Suratman

Suhartono

2022

JKL

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Introduction: Presently, the global consumption of pesticides including insecticides, herbicides, and fungicides to protect crops is increasing. Pesticides' role as Endocrine-Disrupting Chemicals (EDCs) has gained great concern in the field of thyroid hormones. Therefore, this systematic review aimed to determine the link of pesticide exposure with thyroid hormone levels among male agricultural workers and pesticide applicators. Discussion: It was discovered that the majority of reviewed articles have similar results concerning the effects of pesticide exposure on the serum levels of thyroid hormones among either farmworkers or pesticide applicators. Commonly, insecticides, herbicides, and fungicides are known as one of the EDCs. The results showed the elevation of TSH and T4 serum levels mostly occurred among groups exposed to insecticide application only rather than those exposed to various pesticide types. Moreover, the hormonal change differed based on each class of pesticide. Conclusion: This review suggests that some types of pesticides extensively used in agriculture might be involved in the increase and decrease in thyroid hormone levels among exposed individuals. Further studies should assess specific types of pesticides and the adverse health effects which involve confounding factors to yield robust analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pesticides Exposure and Thyroid Hormone Levels Among Agricultural Workers and Pesticide Applicators: A Systematic Review

Suratman

Suhartono

2022

JKL

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“…In the literature, it has been reported that in children and adolescents PFAS levels were higher at the onset of diabetes than in healthy controls. It has also been hypothesized that prenatal exposure to PFAS causes alteration of the lipid profile in infants, which in itself could increase the risk of insular autoimmunity in T1DM [ 13 , 15 , 16 ].…”

Section: Pancreatic Beta-cellsmentioning

confidence: 99%

“…The National Health and Nutrition Examination Survey (NHANES) database cross-sectionally analyzed 1721 adults (see NHANES and Observational Studies) reporting a positive association between diabetes and serum levels of 19 different persistent pollutants (including organochlorine pesticides, OCPs) [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

Guarnotta

Amodei

Frasca

et al. 2022

IJMS

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There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has alarming adverse health effects through both hormone-direct and hormone-indirect pathways. Non-chemical agents, including physical agents such as artificial light, radiation, temperature, and stress exposure, are currently poorly investigated, even though they can seriously affect the endocrine system, by modulation of hormonal action. Several mechanisms have been suggested to explain the interference of EDCs with hormonal activity. However, difficulty in quantifying the exposure, low standardization of studies, and the presence of confounding factors do not allow the establishment of a causal relationship between endocrine disorders and exposure to specific toxic agents. In this review, we focus on recent findings on the effects of EDCs and hormone system modulators on the endocrine system, including the thyroid, parathyroid glands, adrenal steroidogenesis, beta-cell function, and male and female reproductive function.

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Policy Implication and Community Interventions to Reduce EDCs Exposure

Montano,

Guglielmino

2023

Environment Impact on Reproductive Health

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Endocrine-disrupting compounds (EDCs) as emerging pollutants and multi-target agents have accumulated in the environment at concentration levels inducing significant effects on planet and obviously on all living species so that public concern about the impact of EDCs is constantly growing.Moreover, there are many contaminants in the environment which have never been examined. Even low-level exposure to these chemicals can have significant effects, and the same dose response can have different effects on individuals. Furthermore, the cumulative effects of these chemicals are yet to be studied, thus the effect on human beings is not fully understood. Anyway the health consequences of these chemicals have been particularly studied on reproductive system. Male reproductive health, especially, has represented ideal target for analysing the effects and mechanisms of damage to health of these chemical compounds. This field of health is, indeed, critical for the future of society, not only for interdisciplinary approach of several specialists and institutions involved but also for the educational mission of new generations especially in the vulnerable adolescent period; a mission, about lifestyle, diet, behaviour, personal and social awareness to reduce the exposure to EDCs and prevent non-communicable diseases (NCDs). In this chapter, we will discuss policy Implication and Community Interventions to reduce EDCs Exposure for minimisation health damages in the frame of more recent knowledge on these contaminants and proposing how hazard-based approach to guide and reach the regulations should be preferred to the risk-based one. This approach is particularly important to safeguard the male and female reproductive system, which is the most exposed one to environmental stress.

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New insights on the effects of endocrine-disrupting chemicals on children

Cited by 25 publications

References 78 publications

Pesticides Exposure and Thyroid Hormone Levels Among Agricultural Workers and Pesticide Applicators: A Systematic Review

Pesticides Exposure and Thyroid Hormone Levels Among Agricultural Workers and Pesticide Applicators: A Systematic Review

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

Policy Implication and Community Interventions to Reduce EDCs Exposure

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