Climate changes, air pollution and allergic diseases in childhood and adolescence

Urrutia-Pereira, Marilyn; Guidos, Guillermo; Solé, Dírceu

doi:10.1016/j.jped.2021.10.005

Cited by 15 publications

(12 citation statements)

References 44 publications

(62 reference statements)

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“…3 Air pollution constitutes one of the most important environmental contributors to disease today and is known to both cause and aggravate pre-existing asthma. 8,10 Air pollutants irritate the mucosa of the respiratory tract, causing airway inflammation and hyperreactivity. 10 In recent decades, children have been spending a proportionally larger part of the day indoors, meaning that indoor exposures at home and in school constitute a substantial part of the complete environmental setting.…”

Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

“…Exposure to outdoor air pollution in early life has been linked to asthma onset during childhood by effects on inflammation and antioxidation 12 . This has also been linked to poorer lung function and respiratory infections in children 8‐10 . Also, prenatal maternal exposure may increase offspring asthma risk 8 .…”

Section: Key Environmental Exposuresmentioning

confidence: 99%

“…Air pollution constitutes one of the most important environmental contributors to disease today and is known to both cause and aggravate pre‐existing asthma 8,10 . Air pollutants irritate the mucosa of the respiratory tract, causing airway inflammation and hyperreactivity 10 .…”

Section: Key Environmental Exposuresmentioning

confidence: 99%

“…8,10 Air pollutants irritate the mucosa of the respiratory tract, causing airway inflammation and hyperreactivity. 10 In recent decades, children have been spending a proportionally larger part of the day indoors, meaning that indoor exposures at home and in school constitute a substantial part of the complete environmental setting. 11 Nonetheless, tobacco smoke has been most extensively studied in relation to asthma.…”

Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

“…8 Indeed, epigenetic changes, maternal systemic inflammation, and oxidative stress in the placenta have been hypothesized to contribute. 8,10 On the contrary, a farming environment during childhood is in general thought to decrease the risk of asthma, and the effect is particularly marked if the exposure occurs in utero or during the first…”

Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

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Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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Investigation of gene‐environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies have been applied, more recently using genome‐wide approaches. The best example to date is the major asthma locus on the 17q12‐21 chromosome region, viral infections, and airway epithelium processes where recent studies have shed much light on mechanisms in childhood asthma. However, there are challenges with the traditional single variant—single exposure interaction models, as they do not encompass the complexity and cumulative effects of multiple exposures or multiple genetic variants. As such, we need to redefine our traditional GxE thinking, and we propose in this review to expand the GxE concept by also evaluating other omics layers, such as epigenetics, transcriptomics, metabolomics, and proteomics. In addition, host factors such as age, gender, and other exposures are very likely to influence GxE effects and need firmly to be considered in future studies.

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Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

Section: Key Environmental Exposuresmentioning

confidence: 99%

Section: Key Environmental Exposuresmentioning

confidence: 99%

Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

Section: K E Y Environmental E Xp Osure Smentioning

confidence: 99%

See 3 more Smart Citations

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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A prediction of the beginning of the flowering of the common hazel in the Czech Republic

et al. 2022

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Healthcare Disparities in Atopic Dermatitis in Latin America: A Narrative Review

Sánchez

Ale

Angles

et al. 2022

Dermatol Ther (Heidelb)

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Introduction Atopic dermatitis (AD) is a chronic, pruritic skin disease caused by a mixture of genetic, immunological, and environmental factors, characterized by periods of inflammation and remission. In Latin America (LA), the prevalence of AD ranges up to 25% in children and 1–3% in adults. The natural history of the disease for most patients is that AD goes into remission in adolescence and adult life. Only 10–30% of patients continue to have symptoms of the disease in adulthood. There are patients (3–4%) who have the onset of AD during adolescence or after adulthood. Those with limited access to healthcare services, such as diagnosis and treatment, have increased difficulties coping with AD. Healthcare disparities are a complex topic that include social, political, racial/ethnic, and geographical factors. Publications about healthcare disparities in AD in LA are scarce. As a result, recognizing and resolving healthcare inequalities is critical to improving the treatment and quality of life (QoL) of individuals with AD. Methods A panel of Latin American experts in dermatology and allergies was provided with a series of relevant questions to address before a multiday conference. During this conference, the entire group discussed and edited each narrative through numerous drafts and rounds of discussion until they reached a consensus. Results This paper examines the barriers to equal access to care and recommends realistic actions to overcome them. Inadequate disease knowledge, cultural and linguistic barriers, stigmatization, maldistribution of resources, absence of local clinical practice guidelines, arduous patient journey, and limited consultation time were identified as causes of health inequality. Conclusions Among the suggested solutions are enhanced education for healthcare professionals, patients, and the general public, a focus on underprivileged communities, telemedicine and telementoring, translators, multidisciplinary teams, and local living clinical practice guidelines.

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Climate changes, air pollution and allergic diseases in childhood and adolescence

Cited by 15 publications

References 44 publications

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

A prediction of the beginning of the flowering of the common hazel in the Czech Republic

Healthcare Disparities in Atopic Dermatitis in Latin America: A Narrative Review

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