Magnesium sulfate infusion for acute asthma in the emergency department

Irazuzta, José; Chiriboga, Nicolas

doi:10.1016/j.jped.2017.06.002

Cited by 29 publications

(18 citation statements)

References 35 publications

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“…The present study showed that although intravenous magnesium sulfate improves FEV1 and SPO2, and decreases PR, RR and Borg dyspnea score, compared to placebo, in patients with AECOPD in the ED; the differences were not statically significant. Based on previous evidence, the efficacy of intravenous magnesium sulfate in patients with exacerbated asthma has been confirmed (15)(16)(17). Magnesium can potentially inhibit the contraction of bronchial smooth muscle (18).…”

Section: Discussionmentioning

confidence: 97%

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

Jahanian¹,

Khatir²,

Ahidashti³

et al. 2021

Ethiop J Health Sci

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BACKGROUND፡ Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are serious complications that often require immediate intervention in an emergency department (ED). The aim of this study was to investigate the effect of intravenous magnesium sulphate as an adjuvant in the treatment of AECOPD in the ED.METHODS: In a double-blind, randomized clinical trial, a total of 60 patients with AECOPD presenting to the ED of Imam Khomeini Hospital in Sari, Iran, were included. The study was conducted between September 2016 and February 2018. Eligible patients were randomly allocated into two groups of intervention and control. Patients in the intervention and control groups received intravenous infusion of magnesium sulfate (2 gr) or normal saline over 30 minutes, respectively. For all patients, Borgdyspnea score, forced expiratory volume in one second (FEV1) result and clinical variables of interest were evaluated before the beginning of the intervention, and also 45 minutes and 6 hours after the commencement of intervention.RESULTS: Regardless of time of evaluation, pulse rate (PR), respiratory rate (RR) and Borg score in intervention group was lower than control group. Also, FEV1 and SPO2 were greater in intervention group compared to control group. However, these differences were not statistically significant (between-subject differences or group effect) (p<0.001). The trends of FEV1, SPO2, PR, RR and Borg score were similar between two groups of study (no interaction effect; P>0.05).CONCLUSION: According to the results of this study, it seems that using intravenous magnesium sulfate has no significant effect on SPO2, FEV1, RR, and PR of patients with AECOPD who presented to ED.

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Section: Discussionmentioning

confidence: 97%

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

Jahanian¹,

Khatir²,

Ahidashti³

et al. 2021

Ethiop J Health Sci

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“…This antagonizes the action of calcium on the bronchial smooth muscles and causes muscle relaxation and bronchodilation. MgSO 4 could inhibit acetylcholine release at the motor nerve terminals, inhibit histamine release from mast cells, and decrease mucus production in the secretory glands 22,23 . MgSO 4 could enhance the effect of other bronchodilators without causing significant changes in vital signs or adverse effects 24 .…”

Section: Discussionmentioning

confidence: 99%

Intraoperative MgSO₄ infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial

Ahmed

Sayed

El-Kholy

et al. 2020

Acta Anaesthesiol Scand

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Background: The purpose of this study was to examine the effects of an intraoperative MgSO 4 infusion on arterial oxygenation and lung mechanics in patients with moderate COPD undergoing cancer larynx surgery under general anesthesia (GA). Our primary outcome was arterial oxygenation determined by the PaO 2 and PaO 2 / FiO 2. The secondary outcomes were lung mechanics (peak airway pressure, airway plateau pressure, dead space, lung compliance, airway resistance) and postoperative complications. Methods: In this randomized controlled double-blinded trial, 40 patients with an ASA classifications II and/or III who were diagnosed with moderate COPD and who were scheduled for cancer larynx surgery under GA were randomly allocated into two equal groups, the target (Mg group) and control group (C group). In the Mg group, 30 mg/kg of 10% MgSO 4 solution was administered intravenously for over 20 minutes as the loading dose, followed by the continuous infusion of 10 mg/kg/hr In the C group, the same loading and maintenance infusion rates were administered using 0.9% saline. Results: Unlike the C group (baseline "T0" to post-infusion "T1" interval 294 ± 97 vs 238 ± 71 mm Hg, respectively, P = .04 ± SD), the Mg group exhibited preserved intraoperative PaO 2 (T0 to T1 interval 271 ± 89 vs 257 ± 53 mm Hg, respectively, P = .54 ± SD) and PaO 2 /FiO 2 (C group T0 to T1 interval 404 ± 81 vs 349 ± 84, P = .04 and Mg group 394 ± 91 vs 379 ± 95, P = .61, respectively), and these effects were modest. Further, compared to the C group, the Mg group exhibited lower airway resistance, dead space, airway plateau pressure, and peak airway pressure, and higher dynamic compliance. The postoperative PaO 2 and PaO 2 /FiO 2 were higher in the Mg group compared to the C group. Conclusions: Intraoperative infusion of MgSO 4 in patients with moderate COPD undergoing laryngectomy surgery under GA produces mild perioperative protective effects on both arterial oxygenation and lung mechanics.

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“…This hypothesis was verified in multiple clinical trials carried out in subjects with acute severe asthma admitted to emergency room. The results of these studies lay stress on the beneficial effects of therapies based on intravenous administration of magnesium in patients presenting with severe acute asthma [84]. The usefulness of intravenous administration of magnesium sulfate in children affected by asthma has been confirmed by a recent meta-analysis, which also evidenced that the use of nebulized magnesium sulfate has no significant effects on respiratory function [85].…”

Section: Magnesium and Asthma In Childrenmentioning

confidence: 98%

The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

Fanni

Gerosa

Nurchi

et al. 2020

Biol Trace Elem Res

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Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity, bone formation, and immune system competence. Magnesium status is relevant in fetal development during gestation and in the newborn growth during the perinatal period. Moreover, magnesium is able to influence fetal programming and disease presentation in childhood or adulthood. The aim of this review is to focus on this metal homeostasis, analyzing its normal values, the causes of hypomagnesemia, the interaction with drugs and other conditions, and the diseases associated with magnesium value alteration during pregnancy, in order to study its role in fetal programming of adult diseases. The data here reported clearly indicated the existence of a connection between magnesium status and human pathology starting from intrauterine life and extending into childhood and adulthood.

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Magnesium sulfate infusion for acute asthma in the emergency department

Cited by 29 publications

References 35 publications

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

Intraoperative MgSO₄ infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial

The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

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Magnesium sulfate infusion for acute asthma in the emergency department

Cited by 29 publications

References 35 publications

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

The Effect of Intravenous Magnesium Sulphate as an Adjuvant in the Treatment of Acute Exacerbations of COPD in the Emergency Department: A Double-Blind Randomized Clinical Trial

Intraoperative MgSO4 infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial

The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

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Intraoperative MgSO₄ infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial