Breastfeeding increases microbial community resilience

Carvalho‐Ramos, Isabel I.; Duarte, Rubens Tadeu Delgado; Brandt, Kátia Galeão; Martinez, Marina Baquerizo; Taddei, Carla R.

doi:10.1016/j.jped.2017.05.013

Cited by 20 publications

(10 citation statements)

References 28 publications

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“…Our observation that asymptomatic Campylobacter infections are associated with increased diversity among children aged 0–2 years, independent of other enteropathogens, may reflect a disruption of that developmental process. Indeed, breast milk exerts a suppressive effect on diversity in the infant gut, and limited diversity in early life may denote a healthy predominance of bacteria that metabolize breast milk and confer resilience to external insult [ 45–48 ]. This is consistent with the protective effects of exclusive or predominant breastfeeding against Campylobacter reported in this cohort [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort

Rouhani

Griffin

Yori

et al. 2019

Clinical Infectious Diseases

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Background Campylobacter infection is associated with impaired growth of children, even in the absence of symptoms. To examine the underlying mechanisms, we evaluated associations between Campylobacter infection, linear growth, and fecal microbial community features in a prospective birth cohort of 271 children with a high burden of diarrhea and stunting in the Amazonian lowlands of Peru. Methods Campylobacter was identified using a broadly reactive, genus-specific enzyme-linked immunosorbent assay. 16S rRNA-based analyses were used to identify bacterial taxa in fecal samples at ages 6, 12, 18, and 24 months (N = 928). Associations between infection, growth, and gut microbial community composition were investigated using multiple linear regression adjusting for within-child correlations, age, and breastfeeding. Indicator species analyses identified taxa specifically associated with Campylobacter burden. Results Ninety-three percent (251) of children had Campylobacter present in asymptomatic fecal samples during the follow-up period. A 10% increase in the proportion of stools infected was associated with mean reductions of 0.02 length-for-age z scores (LAZ) at 3, 6, and 9 months thereafter (P < .01). We identified 13 bacterial taxa indicative of cumulative Campylobacter burden and 14 taxa significantly associated with high or low burden of enteroaggregative Escherichia coli, norovirus, or Giardia. Conclusions Campylobacter infection is common in this cohort and associated with changes in microbial community composition. These results support the notion that disruptions to the fecal microbiota may help explain the observed effects of asymptomatic infections on growth in early life.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort

Rouhani

Griffin

Yori

et al. 2019

Clinical Infectious Diseases

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“…Thus, it was assumed that continued breastfeeding exerted little influence over the infant gut microbiome once solids were introduced. However, recent metagenomic studies have consistently found that for infants exclusively breastfed for the first 6 months, a characteristic breastmilk microbiome persists beyond the introduction of solids, with the development of adult-like microbial flora deferred until full cessation of breastfeeding (Bäckhed et al, 2015;Carvalho-Ramos et al, 2017;Forbes et al, 2018;Matsuyama et al, 2019). Thus, among dietary factors, it is the provision or withdrawal of breast milk to the infant gut that most strongly shapes the microbiome.…”

Section: More Than Nutrition More Than Passive Immunitymentioning

confidence: 99%

The “weanling's dilemma” revisited: Evolving bodies of evidence and the problem of infant paleodietary interpretation

Kendall

Millard

Beaumont

2021

American J Phys Anthropol

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Breastfeeding is known to be a powerful mediator of maternal and childhood health, with impacts throughout the life course. Paleodietary studies of the past 30 years have accordingly taken an enduring interest in the health and diet of young children as a potential indicator of population fertility, subsistence, and mortality patterns.While progress has been made in recent decades toward acknowledging the agency of children, many paleodietary reconstructions have failed to incorporate developments in cognate disciplines revealing synergistic dynamics between maternal and offspring biology. Paleodietary interpretation has relied heavily on the "weanling's dilemma," in which infants are thought to face a bleak choice between loss of immunity or malnutrition. Using a review of immunological and epidemiological evidence for the dynamic and supportive role that breastfeeding plays throughout the complementary feeding period, this article offers context and nuance for understanding past feeding transitions. We suggest that future interpretative frameworks for infant paleodietary and bioarchaeological research should include a broad knowledge base that keeps pace with relevant developments outside of those disciplines.

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“…HMOs are a diverse set of glycans that, although indigestible to humans, promote the growth of healthy strains of bacteria in the infant gut (Bode, 2012). Exclusive breastfeeding in the first 6 months of life protects the microbiota, increasing its resistance to external influences in infancy (Carvalho-Ramos, Duarte, Brandt, Martinez, & Taddei, 2018).…”

Section: The Development Of the Gut Microbiotamentioning

confidence: 99%

“…HMOs are a diverse set of glycans that, although indigestible to humans, promote the growth of healthy strains of bacteria in the infant gut (Bode, ). Exclusive breastfeeding in the first 6 months of life protects the microbiota, increasing its resistance to external influences in infancy (Carvalho‐Ramos, Duarte, Brandt, Martinez, & Taddei, ). Other research on microbial manipulation focuses on the promise of dietary intervention using probiotics and prebiotics, presented elsewhere in this special issue.…”

Section: The Microbiota–gut–brain Axismentioning

confidence: 99%

The microbiota–gut–brain axis: A promising avenue to foster healthy developmental outcomes

Brett

Weerth

2019

Developmental Psychobiology

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Fostering healthy developmental growth in the first years of life is associated with numerous favorable cognitive, social, and economic outcomes. Funding and promoting research aimed at identifying potential targets for early intervention should be a top priority for lawmakers and funders. One promising avenue of research and potential early intervention is the microbiota–gut–brain axis. In this report, we briefly examine the role of the gut microbiota in human life, focusing on links with health, cognition, and behavior. We then discuss the development of the gut microbiota and the critical early window in which colonization occurs. Then, we review current nonnutritive means of influencing the gut microbiota in early life. Finally, we discuss the implications this work has for early intervention in low‐income communities and end with recommendations regarding further research and research funding priorities.

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Breastfeeding increases microbial community resilience

Abstract: These results suggested an intestinal microbiota pattern resilient to external forces, due to the probiotic and prebiotic effects of exclusive breastfeeding, reinforcing the importance of exclusive breastfeeding until the 6 month of life.

Cited by 20 publications

References 28 publications

Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort

Gut Microbiota Features Associated With Campylobacter Burden and Postnatal Linear Growth Deficits in a Peruvian Birth Cohort

The “weanling's dilemma” revisited: Evolving bodies of evidence and the problem of infant paleodietary interpretation

The microbiota–gut–brain axis: A promising avenue to foster healthy developmental outcomes

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