Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies

Ornellas, Fernanda; Carapeto, Priscila; Mandarim-de-Lacerda, Carlos Alberto; Águila, Márcia Barbosa

doi:10.1016/j.jped.2017.02.004

Cited by 39 publications

(17 citation statements)

References 83 publications

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“…This contrasts with observations and wide reflections on epigenetic 'diabesity' transmission through the paternal line [13][14][15]. Similarly, in contrast to the aforementioned studies and a variety of rather narrative reviews [20,41,42], some other similar approaches also did not confirm respective 'diabesogenic' alterations in the paternal line F1 offspring after HFD exposure [35,43,44]. Accordingly, data and interpretations of paternal/epigenetic 'diabesity' transmission appear to remain inconclusive and need further distinct exploration, as provided here.…”

Section: Discussioncontrasting

confidence: 90%

Maternal but Not Paternal High-Fat Diet (HFD) Exposure at Conception Predisposes for ‘Diabesity’ in Offspring Generations

Schellong

Melchior

Ziska

et al. 2020

IJERPH

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While environmental epigenetics mainly focuses on xenobiotic endocrine disruptors, dietary composition might be one of the most important environmental exposures for epigenetic modifications, perhaps even for offspring generations. We performed a large-scale rat study on key phenotypic consequences from parental (F0) high-caloric, high-fat diet (HFD) food intake, precisely and specifically at mating/conception, focusing on ‘diabesity’ risk in first- (F1) and second- (F2) generation offspring of both sexes. F0 rats (maternal or paternal, respectively) received HFD overfeeding, starting six weeks prior to mating with normally fed control rats. The maternal side F1 offspring of both sexes developed a ‘diabesity’ predisposition throughout life (obesity, hyperleptinemia, hyperglycemia, insulin resistance), while no respective alterations occurred in the paternal side F1 offspring, neither in males nor in females. Mating the maternal side F1 females with control males under standard feeding conditions led, again, to a ‘diabesity’ predisposition in the F2 generation, which, however, was less pronounced than in the F1 generation. Our observations speak in favor of the critical impact of maternal but not paternal metabolism around the time frame of reproduction for offspring metabolic health over generations. Such fundamental phenotypic observations should be carefully considered in front of detailed molecular epigenetic approaches on eventual mechanisms.

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Section: Discussioncontrasting

confidence: 90%

Maternal but Not Paternal High-Fat Diet (HFD) Exposure at Conception Predisposes for ‘Diabesity’ in Offspring Generations

Schellong

Melchior

Ziska

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…The fetal development phase begins at the 9th week of gestation and goes through to the baby’s birth, the human gestation lasting on average 38 weeks ( Dipietro, 2008 ). There are studies that reinforce that epigenetic influences have a strong association with the development of obesity ( Ornellas et al ., 2017 ).…”

Section: Discussionmentioning

confidence: 96%

Dermatoglyphical impressions are different between children and adolescents with normal weight, overweight and obesity: a cross-sectional study

et al. 2019

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Background: Obesity is a health condition that causes a great impact on public health. The aim of this study was to determine the association between dermatoglyphic characteristics and excessive weight in children and adolescents aged 10 to 19 years in the center-west region of Santa Catarina, Brazil. Methods: The sample comprised of 2,172 children and adolescents aged 10 to 19 years old of both sexes and from public and private teaching networks. Results: The results suggested a predictive marker of obesity, with a greater number of lines in left hand finger two (Mesql2) and a higher frequency of the whorl pattern in participants of a healthy weight, while the overweight group had a higher frequency of the radial loop pattern and the obese group had a higher frequency of the ulnar loop pattern. Conclusion: It was concluded that there may be different dermatoglyphic characteristics depending on the nutritional status of children and adolescents.

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“…Kaati et al found that boys exposed to high food availability (an indicator of overfeeding) at 9 to 12 years of age had increased cardiovascular disease and type‐2 diabetes mortality risks in male descendants. Since then, murine models have shown that paternal nutritional experiences and obesity status can exert transgenerational and sex‐specific effects on offspring health. However, when it comes to the primary outcome of the present study (newborn adiposity) insufficient and contrasting data exist in the literature which do not allow to clearly elucidate the effect of paternal obesity on newborn phenotype.…”

Section: Discussionmentioning

confidence: 77%

Parental adiposity differentially associates with newborn body composition

et al. 2019

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Summary Background Maternal obesity increases offspring's obesity risk. However, studies have not often considered maternal metabolic and exercise patterns as well as paternal adiposity as potential covariates. Objective To assess the relationship between parental and newborn adiposity. Methods Participants were mother‐child pairs (n = 209) and mother‐father‐offspring triads (n = 136). Parental (during gestation) and offspring (2 weeks old) percent fat mass (FM) were obtained using air displacement plethysmography. Maternal race, age, resting energy expenditure (indirect calorimetry), physical activity (accelerometry), gestational weight gain (GWG), gestational age (GA), delivery mode, infant's sex and infant feeding method were incorporated in multiple linear regression analyses. The association between parental FM and offspring insulin‐like growth factor 1 (IGF‐1) was assessed at age 2 years. Results Maternal adiposity was positively‐associated with male (β = 0.11, P = .015) and female (β = 0.13, P = .008) infant FM, whereas paternal adiposity was negatively‐associated with male newborn adiposity (β = ‐0.09, P = .014). Breastfeeding, female sex, GA and GWG positively associated with newborn adiposity. Vaginal and C‐section delivery methods associated with greater adiposity than vaginal induced delivery method. Plasma IGF‐1 of 2‐year‐old boys and girls positively associated with their respective fathers' and mothers' FM. Conclusions Maternal and paternal adiposity differentially associate with newborn adiposity. The mechanisms of this finding remain to be determined.

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Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies

Abstract: Paternal obesity can induce programmed phenotypes in offspring through epigenetics. Therefore, it can be considered a public health problem, affecting the children's future life.

Cited by 39 publications

References 83 publications

Maternal but Not Paternal High-Fat Diet (HFD) Exposure at Conception Predisposes for ‘Diabesity’ in Offspring Generations

Maternal but Not Paternal High-Fat Diet (HFD) Exposure at Conception Predisposes for ‘Diabesity’ in Offspring Generations

Dermatoglyphical impressions are different between children and adolescents with normal weight, overweight and obesity: a cross-sectional study

Parental adiposity differentially associates with newborn body composition

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