Risk of recurrence after a first unprovoked seizure in children

Abstract

Most children with a first unprovoked epileptic seizure had no recurrences. The risk of recurrence was higher in patients with seizure occurring during sleep or remote symptomatic ones and those with abnormal electroencephalogram results.

Impact of the Occurrence While Sleeping of First Unprovoked Seizure on Seizure Recurrence: A Systematic Review

“…We therefore assigned two stars to the “comparability” item of the NOS for the nine studies. 3 6 14 15 16 17 18 19 20 We did not assign a star to the “length of follow-up” item for five studies because those studies did not explicitly address the follow-up period. Those five studies provided the median 5 or average 6 15 17 of the follow-up period of all subjects, or only descriptive information.…”

“…Those five studies provided the median 5 or average 6 15 17 of the follow-up period of all subjects, or only descriptive information. 14 The NOS star scores awarded to 13 studies ranged from 7 to 9 points: 1 5 received 7 points, 7 2 6 14 15 17 21 22 received 8 points, and 5 3 16 18 19 20 received 9 points.…”

“…Some people with FUS were lost to follow-up in 3 of the 13 included studies. 6 14 21 In 1 study, 8 out of 176 subjects had only 1 visit to the hospital and never returned. 6 In another study, 17 of the 103 subjects were lost to follow-up, 14 while 11 out of 190 individuals were lost during the follow-up period in the third study.…”

“… 6 14 21 In 1 study, 8 out of 176 subjects had only 1 visit to the hospital and never returned. 6 In another study, 17 of the 103 subjects were lost to follow-up, 14 while 11 out of 190 individuals were lost during the follow-up period in the third study. 21 The seven studies that provided seizure recurrence information at the 2-year follow-up time point for the meta-analyses in the present review had no missing results.…”

“…Those studies provided the follow-up duration of the subjects as a mean or a median, or only descriptive information. 5 6 14 15 17 As a result, we could not include these studies in the meta-analyses, which are instead summarized in Table 3 . The SRRs ranged from 39.7% to 82.8% in the FUS-S group and from 28.1% to 52.8% in the FUS-W group.…”