Prenatal, perinatal and postnatal factors associated with autism spectrum disorder

Hadjkacem, Imen; Ayadi, H.; Turki, M.; Yaïch, S.; Khemekhem, Khaoula; Walha, A.; Chérif, L.; Moalla, Y.; Ghribi, F.

doi:10.1016/j.jped.2016.01.012

Cited by 43 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, 17 studies that met the inclusion criteria were included in this meta-analysis. [26–42] The selection flow chart is shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

“…[49] These adverse effects of maternal diabetes on brain may arise from the intrauterine increased fetal oxidative stress, as well as the epigenetic changes in the expression of several genes. [26] Moreover, the observed risk in maternal diabetes might be related to the pregnancy complications rather than the hyperglycemia complications. Whether control of diabetes would reduce this association still remains unknown.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal, perinatal, and postnatal factors associated with autism

et al. 2017

View full text Add to dashboard Cite

Background:The aim of this meta-analysis was to investigate the prenatal, perinatal, and postnatal risk factors for children autism.Methods:PubMed, Embase, Web of Science were used to search for studies that examined the prenatal, perinatal, and postnatal risk factors for children autism. A fixed-effects model or random-effects model was used to pool the overall effect estimates.Results:Data from 37,634 autistic children and 12,081,416 nonautistic children enrolled in 17 studies were collated. During the prenatal period, the factors associated with autism risk were maternal and paternal age≥35 years, mother's and father's race: White and Asian, gestational hypertension, gestational diabetes, maternal and paternal education college graduate+, threatened abortion, and antepartum hemorrhage. During perinatal period, the factors associated with autism risk were caesarian delivery, gestational age≤36 weeks, parity≥4, spontaneous labor, induced labor, no labor, breech presentation, preeclampsia, and fetal distress. During the postnatal period, the factors associated with autism risk were low birth weight, postpartum hemorrhage, male gender, and brain anomaly. Parity≥4 and female were associated with a decreased risk of autism. In addition, exposure to cigarette smoking, urinary infection, mother's and father's race: Black and Hispanic, mother's country of birth outside Europe and North America, umbilical cord around neck, premature membrane rupture, 5-minutes Apgar score<7, and respiratory infection were not associated with increased risk of autism.Conclusion:The present meta-analysis confirmed the relation between some prenatal, perinatal, and postnatal factors with autism. All these factors were examined individually, thus it was still unclear that whether these factors are causal or play a secondary role in the development of autism. Further studies are needed to verify our findings, and investigate the effects of multiple factors on autism, rather than the single factor.

show abstract

“…Finally, 17 studies that met the inclusion criteria were included in this meta-analysis. [26–42] The selection flow chart is shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prenatal, perinatal, and postnatal factors associated with autism

et al. 2017

View full text Add to dashboard Cite

show abstract

“…It remains unknown, however, whether the development of ASD features is associated with altered neurotransmission in the mPFC-basolateral AMG (BLA) pathway. Using optogenetic techniques (Boyden et al, 2005), we addressed this question in a "two-hit" mouse model (Harvey and Boksa, 2012;Giovanoli et al, 2013;Missig et al, 2018), exploring the possibility that early developmental immune activation can increase the prevalence of ASD-associated dysfunctions (Mrozek-Budzyn et al, 2013;Hadjkacem et al, 2016). In this model, mice received a maternal immune activation (MIA) challenge on embryonic day 12.5 (E12.5) with polyinosinic:polycytidylic acid (Poly I:C), a toll-like receptor 3 TLR3 agonist simulating an innate immune response to a virus, with or without a subsequent postnatal immune activation (PIA) challenge with lipopolysaccharide (LPS), a TLR4 agonist simulating an innate immune response to bacteria, on postnatal day 9 (P9) (Smith et al, 2007;Kawai and Akira, 2008;Reisinger et al, 2015;Canetta et al, 2016;Choi et al, 2016;Custó dio et al, 2017;Patel et al, 2017).…”

Section: Significance Statementmentioning

confidence: 99%

Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC–Amygdala Circuits

Missig

Finger

et al. 2018

J. Neurosci.

View full text Add to dashboard Cite

Inflammatory processes may be involved in the pathophysiology of neuropsychiatric illnesses including autism spectrum disorder (ASD). Evidence from studies in rodents indicates that immune activation during early development can produce core features of ASD (social interaction deficits, dysregulation of communication, increases in stereotyped behaviors, and anxiety), although the neural mechanisms of these effects are not thoroughly understood. We treated timed-pregnant mice with polyinosinic:polycytidylic acid (Poly I:C), which simulates a viral infection, or vehicle on gestational day 12.5 to produce maternal immune activation (MIA). Male offspring received either vehicle or lipopolysaccharide, which simulates a bacterial infection, on postnatal day 9 to produce postnatal immune activation (PIA). We then used optogenetics to address the possibility that early developmental immune activation causes persistent alterations in the flow of signals within the mPFC to basolateral amygdala (BLA) pathway, a circuit implicated in ASD. We found that our MIA regimen produced increases in synaptic strength in glutamatergic projections from the mPFC to the BLA. In contrast, our PIA regimen produced decreases in feedforward GABAergic inhibitory postsynaptic responses resulting from activation of local circuit interneurons in the BLA by mPFC-originating fibers. Both effects were seen together when the regimens were combined. Changes in the balance between excitation and inhibition were differentially translated into the modified spike output of BLA neurons. Our findings raise the possibility that prenatal and postnatal immune activation may affect different cellular targets within brain circuits that regulate some of the core behavioral signs of conditions such as ASD. Immune system activation during prenatal and early postnatal development may contribute to the development of autism spectrum disorder (ASD). Combining optogenetic approaches and behavioral assays that reflect core features of ASD (anxiety, decreased social interactions), we uncovered mechanisms by which the ASD-associated behavioral impairments induced by immune activation could be mediated at the level of interactions within brain circuits implicated in control of emotion and motivation (mPFC and BLA, specifically). Here, we present evidence that prenatal and postnatal immune activation can have different cellular targets in the brain, providing support to the notion that the etiology of ASD may be linked to the excitation/inhibition imbalance in the brain affecting the signal flow within relevant behavior-driving neural microcircuits.

show abstract

“…including birth asphyxia with Apgar scores of <7 at 5 minutes after birth. 102,103 The association between prenatal fever and ASD, as demonstrated in the studies by Brucato 104 and Hornig, 105 can be an indirect warning of the temperature rise in the embryo/fetus when exposed to an undetected high thermal index during ultrasonography.…”

Section: Risk Factors Of Asdmentioning

confidence: 98%

“…The higher mean depth of penetration denotes that greater than expected heat dissipation occurred at 3.5-megahertz transducer frequency and has affected fetal neural tissue development in ASD patients. 71,102,103,132 Ten years after the implementation of ODS, a Swedish assessment 86 revealed that 33% of daily PUS end-users could comprehend the mechanical and thermal indices, 28% were aware of the location of safety indices on their screen, and merely 22% could modify the energy output on their machine. The inadequate knowledge of end-users of the biosafety indices or their screen appearance is widespread among medical professionals in many countries.…”

Section: Safety Of Pusmentioning

confidence: 99%

Is Excessive Prenatal Ultrasonography a Risk Factor for Autism? A Literature Review

Moammar¹,

Sulayman²

2019

Preprint

View full text Add to dashboard Cite

The historic mutual rise of prenatal ultrasonography and autism spectrum disorder and their similarities and controversies in the literature are discussed in this review. Scientific AbstractFor the past several decades, abdominal prenatal ultrasonography has been the most significant technology in obstetrics a s a long-established practice. However, the frequency, exposure time, thermal and cavitation exposure indices, and increased acoustic output of the ultrasonic waves may be harmful to the embryo/fetus and might increase susceptibility to Autism Spectrum Disorder (ASD). The increase in the prevalence of ASD is associated with an affluent ethnicity, high socioeconomic status, and high parental education where prenatal ultrasonography is readily available and affordable. Enhanced biophysical adverse effects may link the analogous increase in prenatal ultrasonography and autism, and prenatal ultrasonography may emerge as a risk factor for autism. Radiography usage provides historical evidence for this fact: the predominant past opinion was that exposure to X-rays during pregnancy caused no significant risk to a fetus. However, the association between X-ray exposure and childhood leukemia was only established 40 years after X-ray use began. This review focuses on excessive PUS usage and ASD development. Public AbstractAdvancements in medical technology over the past several decades have made prenatal ultrasound more frequently accessible to expecting mothers during their pregnancy, especially for the affluent. A parallel development is the increase in autism diagnoses (Autism Spectrum Disorder, or ASD) in children of affluent families. There is a general lack of studies of the impact of prenatal ultrasound on fetuses, especially around varying attributes such as frequency, duration of exposure, and thermal and cavitation indices. There is also a historical precedent set, where Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 4

show abstract

Prenatal, perinatal and postnatal factors associated with autism spectrum disorder

Abstract: The present survey confirms the high prevalence of prenatal, perinatal and postnatal factors in children with ASD and suggests the intervention of some of these factors (acute fetal distress and difficult labor, among others), as determinant variables for the genesis of ASD.

Cited by 43 publications

References 27 publications

Prenatal, perinatal, and postnatal factors associated with autism

Prenatal, perinatal, and postnatal factors associated with autism

Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC–Amygdala Circuits

Is Excessive Prenatal Ultrasonography a Risk Factor for Autism? A Literature Review

Contact Info

Product

Resources

About