Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis

Lago, Eleonor Gastal; Oliveira, Anna Paula de; Bender, Ana Lígia

doi:10.1016/j.jped.2013.12.006

Cited by 21 publications

(5 citation statements)

References 24 publications

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“…These data reinforce the importance of pediatric followups. 3,4,20,30,31 In the present study, the cases of miscarriage due to congenital infection by the parasite, of gestational loss, and of premature rupture of membranes were not observed as complications of having performed amniocentesis. It is known that such an invasive procedure in fetal medicine presents a rate of 1% of risks of complications.…”

Section: Discussionmentioning

confidence: 41%

Follow-up of Toxoplasmosis during Pregnancy: Ten-Year Experience in a University Hospital in Southern Brazil

Diesel

Záchia

Müller

et al. 2019

Rev Bras Ginecol Obstet

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Objective To describe a population of pregnant women diagnosed with toxoplasmosis and their respective newborns, describing the hospital protocol for treatment and follow-up. Methods Retrospective cohort of pregnant women with acute toxoplasmosis infection and risk of transplacental transmission who were sent to the Fetal Medicine Group of Hospital de Clínicas de Porto Alegre (HCPA) between -January 1, 2006 and December 31, 2016. All patients with confirmed disease were included. The diagnostic protocol and treatment were applied; a polymerase chain reaction (PCR) analysis of the amniotic fluid was used to diagnose toxoplasmosis and determine the treatment. The newborns were followed up at the pediatric outpatient clinic specializing in congenital infection. The patients who were not followed up or were not born in the HCPA were excluded. Results A total of 65 patients were confirmed to have gestational toxoplasmosis; 40 performed amniocentesis, and 6 (15%) were identified as having positive PCR in the amniotic fluid. In five of those cases, this result associated with the gestational age defined the triple therapy during pregnancy, and in one case, it defined the monotherapy (advanced gestational age). A total of 4 of these newborns were treated from birth with triple therapy for 10 months, 1 was not treated (due to maternal refusal), and 1 progressed to death within the first 54 hours of life due to complications of congenital toxoplasmosis. Of the 34 remaining cases with a negative PCR, 33 were treated with monotherapy and 1 was treated with triple therapy (ultrasound findings); of these children, 9 (26.5%) presented negative immunoglobulin G (IgG), 24 (70.6%) presented Ana Lúcia Letti Müller's ORCID is https://orcid.org/0000-0003-1214-5664.

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Section: Discussionmentioning

confidence: 41%

Follow-up of Toxoplasmosis during Pregnancy: Ten-Year Experience in a University Hospital in Southern Brazil

Diesel

Záchia

Müller

et al. 2019

Rev Bras Ginecol Obstet

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“…Detection of T. gondii DNA by molecular methods is quite controversial as there are several techniques and markers to identify the DNA of the parasite, and there is no consensus on which protocol is the best. Moreover, the treatment of pregnant women can modify the results of serological and molecular tests, as has been described by some authors (Lago et al, 2014;Lefevre-Pettazzoni et al, 2007;McLeod, 2014;Okay et al, 2009;Robert-Gangneux and Dardé, 2012).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serological and molecular tests used to identify Toxoplasma gondii infection in pregnant women attended in a public health service in São Paulo state, Brazil

Murata

Ferreira

Pereira-Chioccola

et al. 2017

Diagnostic Microbiology and Infectious Disease

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Toxoplasmosis during pregnancy can have severe consequences. The use of sensitive and specific serological and molecular methods is extremely important for the correct diagnosis of the disease. We compared the ELISA and ELFA serological methods, conventional PCR (cPCR), Nested PCR and quantitative PCR (qPCR) in the diagnosis of Toxoplasma gondii infection in pregnant women without clinical suspicion of toxoplasmosis (G1=94) and with clinical suspicion of toxoplasmosis (G2=53). The results were compared using the Kappa index, and the sensitivity, specificity, positive predictive value and negative predictive value were calculated. The results of the serological methods showed concordance between the ELISA and ELFA methods even though ELFA identified more positive cases than ELISA. Molecular methods were discrepant with cPCR using B22/23 primers having greater sensitivity and lower specificity compared to the other molecular methods.

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“…In addition, the clinical manifestations of toxoplasmosis in newborns include hepatosplenomegaly, jaundice, lymphadenomegaly, thrombocytopenia, and anemia [46,47]. The positive period may be quite short in newborns with anti- Toxoplasma IgM; in addition, newborns with CT can have negative anti- Toxoplasma IgM at birth [48]. In a study conducted by Alameh & Tavangar [24], 7 newborns with anti- Toxoplasma IgG did not have the IgM antibodies; however, only 1 neonate had microcephaly and hypotony.…”

Section: Discussionmentioning

confidence: 99%

Congenital toxoplasmosis among Iranian neonates: a systematic review and meta-analysis

et al. 2019

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Toxoplasmosis is a serious zoonotic disease that can lead to abortion and congenital disorders and has a widespread global distribution in humans and animals. The objective of this review was to investigate the incidence of toxoplasmosis in Iranian neonates in order to obtain a comprehensive assessment of the overall situation of the disease for use in developing future interventions. Original studies investigating the incidence of Toxoplasma gondii infections in Iranian neonates were systematically searched in a number of English-language and Persian-language electronic databases. The search process resulted in the inclusion of a total of 11 studies in the systematic review, 10 of which were entered into the meta-analysis. The reviewed articles included 2,230 Iranian neonates investigated through January 1, 2018. Based on the retrieved studies, the overall weighted incidence rates of toxoplasmosis in the Iranian neonatal population and neonates with suspected congenital toxoplasmosis were estimated to be 0.64% (95% confidence interval [CI], 0.31 to 1.09) and 4.10% (95% CI, 2.68 to 5.77), respectively, using a fixed-effects model. The findings of the reviewed studies demonstrate that the incidence of toxoplasmosis is high in Iranian neonates. Accordingly, it can be concluded that toxoplasmosis is a serious public health concern that has been ignored by the Ministry of Health. Therefore, it is essential to perform further studies, in addition to implementing screening and detection programs, using standardized methods to estimate the incidence of toxoplasmosis in Iran and to determine its associated risk factors.

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Presence and duration of anti-Toxoplasma gondii immunoglobulin M in infants with congenital toxoplasmosis

Cited by 21 publications

References 24 publications

Follow-up of Toxoplasmosis during Pregnancy: Ten-Year Experience in a University Hospital in Southern Brazil

Follow-up of Toxoplasmosis during Pregnancy: Ten-Year Experience in a University Hospital in Southern Brazil

Evaluation of serological and molecular tests used to identify Toxoplasma gondii infection in pregnant women attended in a public health service in São Paulo state, Brazil

Congenital toxoplasmosis among Iranian neonates: a systematic review and meta-analysis

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