A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children

Kelishadi, Roya; Farajian, Sanam; Safavi, Sayyed Morteza; Mirlohi, Maryam; Hashemipour, Mahin

doi:10.1016/j.jped.2013.07.003

Cited by 32 publications

(24 citation statements)

References 29 publications

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“…The synergistic benefits have been documented for disease conditions such as obesity and diabetes. A study by Kelishadi et al evaluated the anti-inflammatory effects of synbiotics in the overweight pediatric population [21]. Their data suggested that therapy with synbiotics had an impact on inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease

Yao¹,

Jia²,

Huang³

et al. 2019

aoms

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IntroductionNonalcoholic fatty liver disease (NAFLD) is a growing health concern worldwide. Administration of probiotics and prebiotics has been proposed as a convenient and effective treatment. Our study aims to evaluate the therapeutic benefits of Lactobacillus paracasei N1115 (N1115) and fructooligosaccharides (FOS) by examining the histopathogenesis and underlying molecular events of NAFLD.Material and methodsAn NAFLD mouse model was established by feeding C57BL/6 mice with a high-fat diet (HFD). N1115, FOS and synbiotics were administered for 16 weeks.ResultsN1115, FOS and synbiotics alleviated HFD-induced hepatic steato-sis and release of tumor necrosis factor-α, and slowed the progression of cirrhosis. Compared to the HFD group, these dietary supplements reduced serum total triglyceride and cholesterol, and appeared to decrease the fasting blood glucose and insulin. Intraperitoneal glucose tolerance tests, homeostatic model assessment of insulin resistance and real-time PCR showed that the regimens could overcome insulin resistance. These findings were associated with the transcriptional repression of inflammatory factors such as lipopolysaccharides, Toll-like receptor 4 and nuclear factor-κB. Lastly, N1115, FOS, and synbiotics improved the intestinal barrier functions and histologic integrity. This was accompanied by the restoration of the p38 MAPK pathway and in-creased expression of the tight junction components occludin-1 and claudin-1.ConclusionsN1115, FOS and synbiotics are effective in the prevention and treatment of NAFLD. Our data support the translation of these agents into clinical evaluation in human subjects with NAFLD and/or associated risk factors.

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Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease

Yao¹,

Jia²,

Huang³

et al. 2019

aoms

View full text Add to dashboard Cite

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“…According to these results, it can be proposed the favorable effects of probiotics in reducing inflammation in obese people 12 . In fact, studies have suggested some beneficial effects of probiotics in controlling excess weight in adults 13 ; experience, however, is limited in children.…”

Section: Sirsmentioning

confidence: 96%

“…In fact, studies have suggested some beneficial effects of probiotics in controlling excess weight in adults 13 ; experience, however, is limited in children. Kelishadi et al 12 supplemented synbiotics (combination of probiotic and prebiotic) in obese children and adolescents and concluded that supplementation reduced the inflammatory markers levels (IL-6, TNF-a), which are dependent to its effect on weight reduction in overweight and obese children.…”

Section: Sirsmentioning

confidence: 99%

Is there any association among dental caries, obesity, oral and intestinal microbiome, and pre‐ or probiotics? searching for evidences

Barros

Pinho

Mafra

et al. 2014

Int J Paed Dentistry

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“…Synbiotics are a mixture of pro- and prebiotics which, when ingested, are able to modulate gut microbiota and intestinal immunity ( 151 ). In a recent clinical trial, Kelishadi and associates ( 152 ) have administered overweight children with a synbiotic (Protexin-London, England) composed by a combination of viable Lactobacilli of human origin and fructo-oligosaccharides, as prebiotics. Treated subjects exhibited a significant reduction in weight as well as in TNF-α and IL-6 with an increase in adiponectin in comparison to the placebo group.…”

Section: Probioticsmentioning

confidence: 99%

Childhood Obesity: Immune Response and Nutritional Approaches

Magrone

Jirillo

2015

Front. Immunol.

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Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.

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A randomized triple-masked controlled trial on the effects of synbiotics on inflammation markers in overweight children

Abstract: the present findings suggest the positive influence of synbiotic supplementation on inflammation factors, which are dependent to its effect on weight reduction in overweight and obese children.

Cited by 32 publications

References 29 publications

Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease

Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease

Is there any association among dental caries, obesity, oral and intestinal microbiome, and pre‐ or probiotics? searching for evidences

Childhood Obesity: Immune Response and Nutritional Approaches

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