“Less is more”: decreasing antibiotic days in the NICU

Kaufman, David

doi:10.1016/j.jped.2013.06.001

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…A study by Chiu et al also showed that appropriate empiric treatment of suspected CoNS LOS significantly reduced the use of vancomycin [35]. As reported by Kaufman, accuracy in diagnosis and use of antimicrobial agents are important to prevent neonatal mortality related to sepsis [36]. In our study, 65.1% of the neonates who tested positive for Gram-positive organisms and 53.8% of the neonates who tested positive for Gram-negative organisms had their initial antibiotic therapies continued.…”

Section: Discussionsupporting

confidence: 66%

Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

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Background: This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period. Methods: We performed a retrospective study on neonates with LOS from Jan1, 2011 to Dec 31, 2017. The demographic, clinical, and laboratory data of neonates with LOS were analyzed. Logistic regression was used to investigate the risk factors with mortality. Results: During the study period, 202 neonates with LOS were finally identified. The most common pathogens were Escherichia coli (29.2%), followed by Klebsiella pneumoniae (19.3%), and Coagulase-negative Staphylococcus (CoNS) (16.8%). Nearly 90% of the K. pneumoniae were resistant to cefazolin and 71.8% to ceftazidime. Thirty-four patients (16.8%) died. Multivariable logistic regression showed that significant predictors of mortality were birth weight < 1500 g, respiratory distress and convulsions. Conclusions: Gram-negative organisms have an important role in LOS in our region, with high levels of resistance to third-generation cephalosporins. These data may help in the selection of antibiotics for empirical treatment of neonates with sepsis.

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Section: Discussionsupporting

confidence: 66%

Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

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Evaluation of national health‐care related infection criteria for epidemiological surveillance in neonatology

Ferreira

Bouzada

Jesus

et al. 2014

Jornal de Pediatria

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Empirical antimicrobial therapy for late-onset sepsis in a neonatal unit with high prevalence of coagulase-negative Staphylococcus

Romanelli

Anchieta

Silva

et al. 2016

Jornal de Pediatria

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Modification of the empiric treatment regimen for neonatal late-onset sepsis with use of oxacillin showed a significant reduction in S. aureus infections, as well as a reduction in the frequency of infections with major organ system involvement and mortality due to infection with this microorganism. As a result, oxacillin can be considered as an effective treatment for late-onset sepsis, making it possible to avoid broad-spectrum antibiotics.

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“Less is more”: decreasing antibiotic days in the NICU

Cited by 6 publications

References 9 publications

Late-onset neonatal sepsis in Suzhou, China

Late-onset neonatal sepsis in Suzhou, China

Evaluation of national health‐care related infection criteria for epidemiological surveillance in neonatology

Empirical antimicrobial therapy for late-onset sepsis in a neonatal unit with high prevalence of coagulase-negative Staphylococcus

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