2013
DOI: 10.1016/j.jped.2013.01.008
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Abstract: This study demonstrated that the 388 G>A mutation of the SLCO1B1 gene is a risk factor for developing neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations; the SLCO1B1 521 T>C mutation provides protection for neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian, or Malaysian populations.

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Cited by 12 publications
(12 citation statements)
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“…These conditions are frequently found in Caucasian and African populations [7, 8]. Another gene that has been gaining attention, one that is mostly found in Asian populations, is OATP2/SLCO1B1 [9]. SLCO1B1 (solute carrier organic anion transporter family member 1b1) encodes the solute carrier organic anion transporter family member 1B1 and is responsible for the absorption of unconjugated and conjugated bilirubin in the liver.…”
Section: Introductionmentioning
confidence: 99%
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“…These conditions are frequently found in Caucasian and African populations [7, 8]. Another gene that has been gaining attention, one that is mostly found in Asian populations, is OATP2/SLCO1B1 [9]. SLCO1B1 (solute carrier organic anion transporter family member 1b1) encodes the solute carrier organic anion transporter family member 1B1 and is responsible for the absorption of unconjugated and conjugated bilirubin in the liver.…”
Section: Introductionmentioning
confidence: 99%
“…SLCO1B1 (solute carrier organic anion transporter family member 1b1) encodes the solute carrier organic anion transporter family member 1B1 and is responsible for the absorption of unconjugated and conjugated bilirubin in the liver. This gene, located in chromosome 12p12, consists of 15 exons (1 coding exon and 1 non-coding exon) and 14 introns, as well as containing 2073 nucleotides in the gene-coding area [9]. Neonates carrying this gene polymorphism are associated with reduced bilirubin clearance which induces hyperbilirubinemia [10].…”
Section: Introductionmentioning
confidence: 99%
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“…The OATP2 gene is located at chromosome 12p12 and may be involved in the transportation of both conjugated and unconjugated bilirubin from blood to hepatocytes (Huang et al., ). Although 14 nonsynonymous OATP2 single‐nucleotide polymorphisms (SNPs) have been reported previously, a variation at the nt 388 (A→G substitution) was found to be a risk factor for severe hyperbilirubinemia by altering the transportation of bilirubin among Taiwanese (Huang et al., ) and Chinese neonates but not in Thai, Latin American, or Malaysian neonates (Liu et al., ). Kameyama et al.…”
Section: Discussionmentioning
confidence: 99%