Critical role of mast cells in inflammatory diseases and the effect of acute stress

Theoharides, Theoharis C.; Cochrane, David E.

doi:10.1016/j.jneuroim.2003.10.041

Cited by 386 publications

(314 citation statements)

References 217 publications

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“…Mast cells are normally present around the blood vessels, skin, gastrointestinal tract and lungs, sites where it is exposed to foreign /external agents. Mast cells act as a first defense against invasion by outside agents (Theoharides and Cochrane, 2004).…”

Section: Discussionmentioning

confidence: 99%

Significance of mast cells in non-neoplastic and neoplastic lesions of uterine cervix

Kalyani

Rajeshwari

2016

Biomed Res Ther

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Abstract-Background:Mast cells are involved in multiple biological events. The significance of mast cells in non-neoplastic and neoplastic lesions of the cervix has been studied with conflicting results. Its presence in a tumor has been described as evidence of host immunologic antitumor response, angiogenesis and tumor invasion. Aims/Objectives: To study mast cell density in various cervical lesions using Toluidine blue stain. To compare the sections studied with conventional Toluidine blue staining and Toluidine blue staining by reducing the pH. Methodology: Cervical biopsy/hysterectomy specimens from archives of the Department of Pathology were considered for the study. The sections were studied for histomorphology and mast cell density. The mast cell density was assessed by Toluidine blue staining by conventional method and another method by reducing pH using weak HCL. The stained slides were reviewed for mast cell density under 10 high power field and statistically analyzed. Results: Total of 100 cases was studied. Normal cervix 7 cases with the mean age of 44.29 and the mean mast cell density of 45.43. Chronic cervicitis and polypoidal endocervicitis were 26 and 28 cases, the mean age of 45.38 years and 39.14 years and the mean mast cell count of 48.38 and 66.96 respectively. Intraepithelial lesions and malignancy were 23 and 16 cases, the mean age of 43.56 years and 52.26 years and the mean mast cell of 34.47and 34.6 respectively. The maximum number of mast cells was seen in polypoidal endocervicitis and the least number in squamous cell carcinoma of cervix. Conclusion: The role of mast cell differs in inflammatory and neoplastic lesions of cervix. Mast cells has an active role in inflammatory lesions.

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Section: Discussionmentioning

confidence: 99%

Significance of mast cells in non-neoplastic and neoplastic lesions of uterine cervix

Kalyani

Rajeshwari

2016

Biomed Res Ther

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“…Mast cells are recognized as the key components of allergic inflammatory reactions, but they are also implicated in the pathogenesis of a number of chronic inflammatory diseases, in wound healing, in fibrosis, thrombosis/fibrinolysis, and in innate immunity (reviewed in [11][12][13][18][19][20]). They are described as long-living cells keeping relatively constant numbers in tissues under physiologic conditions.…”

Section: Mast Cellsmentioning

confidence: 99%

P2 receptor-mediated signaling in mast cell biology

Bulanova

Bulfone–Paus∥

2009

Purinergic Signalling

100

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Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and antitumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.

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“…Local down-regulation of the blood-brain barrier leads to enhanced mediator access onto the perivascular mast cells. The fact that acute stress situations both stimulate mast cells and lead to exacerbation of MS [9,34] further indicates importance of mast cells in the enigmatic disease multiple sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Mast cells and multiple sclerosis in females and males

Krüger¹,

Mörk²

2012

WJNS

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Mast cells were observed in autopsies from 11 females and 8 males. We confirm earlier observations that mast cells are more frequent in close vicinity to MSplaques. In these plaque-border zone areas, defined as the area within 1 mm distance of the actual plaques, the average number of mast cells was 2.34/mm 2 in males and 4.77/mm 2 in females, which in average is appr. 10 times more than earlier observed in MS. The difference in number of mast cells between females and males is significant (p < 0.005) and is of interest since females are more inclined to developing MS than males. Mast cells were rare in areas without visible plaques. The mast cells were preferably located close to capillaries and venules. A mechanism for the probable role of mast cells, based on diet-factors and mast cell mediators in the pathogenesis of MS is discussed.

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Critical role of mast cells in inflammatory diseases and the effect of acute stress

Cited by 386 publications

References 217 publications

Significance of mast cells in non-neoplastic and neoplastic lesions of uterine cervix

Significance of mast cells in non-neoplastic and neoplastic lesions of uterine cervix

P2 receptor-mediated signaling in mast cell biology

Mast cells and multiple sclerosis in females and males

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