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Cited by 147 publications
(49 citation statements)
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References 33 publications
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“…Contrary to these investigations, no observed effects were seen at concentrations of 320 µg/L in rainbow trout after 95 days' exposure (Memmert et al, 2013). The NSAIDs ibuprofen and mefenamic acid increased 17β-estradiol, testosterone and transcription of CYP19A gene levels in zebrafish (Ji et al, 2013), indicating that these compounds havebehaviours of endocrine disrupter.…”
Section: Page 10 Of 48contrasting
confidence: 62%
“…Contrary to these investigations, no observed effects were seen at concentrations of 320 µg/L in rainbow trout after 95 days' exposure (Memmert et al, 2013). The NSAIDs ibuprofen and mefenamic acid increased 17β-estradiol, testosterone and transcription of CYP19A gene levels in zebrafish (Ji et al, 2013), indicating that these compounds havebehaviours of endocrine disrupter.…”
Section: Page 10 Of 48contrasting
confidence: 62%
“…This finding indicates that the late embryonic hatching was due to a parental effect. Interestingly, late-hatching embryos can be obtained from zebrafish and medaka breeders exposed to endocrine disrupting drugs such as ibuprofen [50, 51] and diclofenac [52]. Although both males and females were exposed to the drugs in those studies, the results suggest that embryonic hatching is affected by the parental conditions.…”
Section: Discussionmentioning
confidence: 99%
“…Although both males and females were exposed to the drugs in those studies, the results suggest that embryonic hatching is affected by the parental conditions. In fact, the gene expression of several reproductive hormones such as gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone was disrupted in male and female zebrafish exposed to ibuprofen [51]. Taken together, the KO of the valop genes in zebrafish is proposed to delay embryonic hatching due to a mutation-related parental hormonal control on the embryo.…”
Section: Discussionmentioning
confidence: 99%
“…Study has shown that alteration in the HPO axis leads to disruption of ovarian functions [1]. Non-steroidal anti-inflammatory drugs such as ibuprofen and mefenamic acids have been shown to have high endocrine disruption potentials [2]. Ibuprofen is a (2RS)-1[4-(2-methyl propyl phenyl propionic acid that is commonly and frequently used non-steroidal antiinflammatory drugs (NSAIDs) [3].…”
Section: Introductionmentioning
confidence: 99%