Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

Hayat, Muhammad Khizar; Sarwar, Sadia; Anjum, Shazia; Uzair, Muhammad; Rasheed, Hafiz Muhammad Farhan; Jabeen, Qaiser; Choudhary, Bashir Ahmad; Ashraf, Muhammad

doi:10.1016/j.jep.2014.08.038

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…Intestinal worms and constipation.[THH]; [76]31. Euphorbia prostrata Ait. [2503/CIDS/IUB]Hazar-daniEuphorbiaceaeWhole plantPiles, sexual weakness, skin redness and irritation and pain.[THH]; [76]32. Fagonia cretica Linn [2675/CIDS/IUB]DhmasaZygophyllaceaeWhole plantLiver diseases, lack of blood, fever, pain and as blood purifier and increase stamina.(THH)33. Farsetia hamiltonii Royle [2313/CIDS/IUB]Lathi orBrassicaceaeWhole plantAs tonic and against stomachache and joint, muscle pain and diabetes[THH]; [77]Farid- booti34. Gisekia pharnaceoides Linn. [2101/CIDS/IUB]Buloka-sagAizoaceaeWhole plantJaundice, inappropriate eating habits, fever and pain.[THH]; [78]Constipation, remove intestinal worms and skin infections.35. Glinus lotoides Linn [2514/CIDS/IUB]Gandi-bootiMolluginaceaeWhole plantDiarrhea, poor functioning of liver, externally to cure boils and wounds.[THH]36. Grewia villosa Willd.…”

Section: Resultsmentioning

confidence: 99%

A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines

Malik

Ahmad

Sadiq

et al. 2015

J Ethnobiology Ethnomedicine

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BackgroundThe present study is intended to compare and document the therapeutic flora, their remedial use, and the traditional knowledge used frequently by the residents of the Cholistan desert and Pothwar (Potohar) Plateau of Punjab, Pakistan. The old endemic remedies of these areas are diminishing due to lack of qualitative and quantitative research.MethodsThe data was generated by unstructured-interviews, informal meetings, open-ended conversations and group discussions with local people and traditional health healers of the study area. Reported literature was also utilized.ResultsThe study recorded a list of various medicinal plants used as traditional medicines by local people. Total 86 numbers of plant species belonging to 38 families and 67 plant species belonging to 29 families have been reported in the Pothwar and Cholistan respectively. Only 10.5% of similar plant species were present in the studied areas.ConclusionThe investigation revealed that the local people of study areas inherit a rich traditional knowledge but there is great danger of losing this wealth of knowledge in the near future. Documentation of the knowledge exclusively from desert area of Cholistan, Pakistan is unique information in its nature. The study presents the undocumented knowledge worth recognition that will not only help in conservation of medicinal plant species but will highlight the pharmacological capacity for improved human healthcare regarding many common ailments.

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Section: Resultsmentioning

confidence: 99%

A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines

Malik

Ahmad

Sadiq

et al. 2015

J Ethnobiology Ethnomedicine

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“…As a result, multiple reports have used cp genomes to identify phylogenetic connections in the Brassicaceae family [12,22,23]; however the systematic position of the Farsetia genus remains unknown because there is no published literature confirming their phylogenetic position based on Chloroplast genome. Farsetia, an essential medicinal plant of the Brassicaceae family clade C [74], provides significant genetic assets for creating and identifying other valuable species. Understanding evolutionary links between F. hamiltonii and the other 21 species belonging to 17 other Brassicaceae tribes may guide the genetic variation of beneficial genes into comparable species.…”

Section: Discussionmentioning

confidence: 99%

The chloroplast genome of Farsetia hamiltonii Royle, phylogenetic analysis, and comparative study with other members of Clade C of Brassicaceae

et al. 2022

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Background Farsetia hamiltonii Royle is a medicinally important annual plant from the Cholistan desert that belongs to the tribe Anastaticeae and clade C of the Brassicaceae family. We provide the entire chloroplast sequence of F.hamiltonii, obtained using the Illumina HiSeq2500 and paired-end sequencing. We compared F. hamiltonii to nine other clade C species, including Farsetia occidentalis, Lobularia libyca, Notoceras bicorne, Parolinia ornata, Morettia canescens, Cochlearia borzaeana, Megacarpaea polyandra, Biscutella laevigata, and Iberis amara. We conducted phylogenetic research on the 22 Brassicaceae species, which included members from 17 tribes and six clades. Results The chloroplast genome sequence of F.hamiltonii of 154,802 bp sizes with 36.30% GC content and have a typical structure comprised of a Large Single Copy (LSC) of 83,906 bp, a Small Single Copy (SSC) of 17,988 bp, and two copies of Inverted Repeats (IRs) of 26,454 bp. The genomes of F. hamiltonii and F. occidentalis show shared amino acid frequencies and codon use, RNA editing sites, simple sequence repeats, and oligonucleotide repeats. The maximum likelihood tree revealed Farsetia as a monophyletic genus, closely linked to Morettia, with a bootstrap score of 100. The rate of transversion substitutions (Tv) was higher than the rate of transition substitutions (Ts), resulting in Ts/Tv less than one in all comparisons with F. hamiltonii, indicating that the species are closely related. The rate of synonymous substitutions (Ks) was greater than non-synonymous substitutions (Ka) in all comparisons with F. hamiltonii, with a Ka/Ks ratio smaller than one, indicating that genes underwent purifying selection. Low nucleotide diversity values range from 0.00085 to 0.08516, and IR regions comprise comparable genes on junctions with minimal change, supporting the conserved status of the selected chloroplast genomes of the clade C of the Brassicaceae family. We identified ten polymorphic regions, including rps8-rpl14, rps15-ycf1, ndhG-ndhI, psbK-psbI, ccsA-ndhD, rpl36-rps8, petA-psbJ, ndhF-rpl32, psaJ-rpl3, and ycf1 that might be exploited to construct genuine and inexpensive to solve taxonomic discrepancy and understand phylogenetic relationship amongst Brassicaceae species. Conclusion The entire chloroplast sequencing of F. hamiltonii sheds light on the divergence of genic chloroplast sequences among members of the clade C. When other Farsetia species are sequenced in the future, the full F. hamiltonii chloroplast will be used as a source for comprehensive taxonomical investigations of the genus. The comparison of F. hamiltonii and other clade C species adds new information to the phylogenetic data and evolutionary processes of the clade. The results of this study will also provide further molecular uses of clade C chloroplasts for possible plant genetic modifications and will help recognise more Brassicaceae family species.

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“…Also, It was observed that 10% DMSO is a good solvent for methanolic crude extracts and it has no effect on the bacterial growth. Farsetia hamitonii is a typical desert plant, with some medicinal applications, it is employed as antirheumatic and tonic (Hayat et al, 2015). However, to the best of our knowledge, there is no adequate antimicrobial studies on this plant that has been reported till now and our findings suggest that methanol extract of this plant has no antimicrobial activity, although different species of Farsetia (Farsetia aegyptia ) was reported to possess significant antimicrobial activity against Klebsiella pneumonia and Aspergillus niger .…”

Section: Resultsmentioning

confidence: 59%

“…Also, the methanol extract of F. hamiltonii contains quercetin that has a powerful antioxidant activity (Gordon et al, 1998). A study in Algeria showed that the antioxidant activity of F. hamiltonii (methanolic extract) was not significant because it is poor in substances that have an antioxidant activity (Hayat et al, 2014;Hayat et al, 2015). In another study, the chromatographic purification showed that the methanol extract of L. nudicaulis contains substances which don't have antioxidant activity (Saleem et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical, antimicrobial and antioxidant properties of Launaea nudicaulis and Farsetia hamiltonii

Elsharkawy

Ed-Dra²,

Abdallah

2017

Journal of Biological Control

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Plant extracts could be beneficial for biocontrol of macro-organisms and micro-organisms which attack plants and it could be also beneficial for protection or treatment of some diseases in animals and human. In the current study, two plants from the arid areas in the Northern Regions in Saudi Arabia, namely, Farsetia hamiltonii and Launaea nudicaulis were screened for their phytochemical, antimicrobial and antioxidant properties. GC-MS screening of methanol extract of flowers of F. hamiltonii revealed the presence of triterpen compound (Betulins, Lanosterin), and quercterin. The methanol extract of L. nudicaulis revealed the presence of dihydro-isosteviolmethylester and flavone-4'-OH,5-OH,7-di-O-glucoside. Dihydrotorulosol and Urs-12-ene-3-one were detected in two extracts, where chloroform extract of Launaea were rich in alkaloid compounds, aspidofractinin, and tocopherol. The antioxidant activity showed that the chloroform extract of L. nudicaulis had higher antioxidant activity (IC50=1.6±0.1g/L; EC50=2.15±0.3g/L), followed by methanol extract of F. hamiltonii (IC50=3.6±0.1g/L; EC50=4.1±0.1g/L) and methanol extract of L. nudicaulis (IC50=7.1±0.2g/L;EC50=7.85±0.4g/L). The microbiological investigation revealed that methanol extract of F. hamitonii and chloroform extract of Launaea nudicaulis showed no antimicrobial activity against all tested microorganisms. While the methanol extract of L. nudica exhibited average antibacterial activity against Staphylococcus epidermidis ATCC 12228 and weak antibacterial activity against S. aureus ATCC 25923 and Escherichia coli ATCC 35218.

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Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert

Cited by 12 publications

References 19 publications

A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines

A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines

The chloroplast genome of Farsetia hamiltonii Royle, phylogenetic analysis, and comparative study with other members of Clade C of Brassicaceae

Phytochemical, antimicrobial and antioxidant properties of Launaea nudicaulis and Farsetia hamiltonii

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