Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss

Cushnie, T.P. Tim; Lamb, Andrew J.

doi:10.1016/j.jep.2005.04.014

Cited by 129 publications

(82 citation statements)

References 26 publications

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“…Saponins, tannins and carbohydrates were strongly indicated while alkaloids and cardiac glycosides were absent. These phytochemicals have been suggested to be responsible for the antimicrobial effect of some plant extracts (Rahman et al, 2009;Mahesh & Satish, 2008;Ankri & Mirelman, 1999;Cushnie & Lamb, 2005). Flavonoids have been reported to possess many useful properties including enzyme inhibition, anti-inflammatory activity, oestrogenic activity, antimicrobial activity (Havsteen, 1983;Harbone & Baxter, 1999), antiallergic activity and antioxidant activity (Abbas et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The antibacterial activity of flavonoids is being increasingly documented. Extracts from plants with a history of use in folk medicine have been screened in vitro for antibacterial activity by many research groups (Cushnie & Lamb, 2005). Some of the proposed mechanisms for the antibacterial activity of flavonoids include; inhibition of nucleic acid synthesis (Mori et al, 1987), inhibition of cytoplasmic membrane function (Tsichuya & Linama, 2000) and inhibition of energy metabolism (Haraguchi et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

Uchenna¹,

Adaeze²,

Steve³

2015

JAS

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Phytochemical analysis and antimicrobial activities of the aqueous ethanolic extract of Saccharum officinarum were carried out. The antimicrobial activity was screened by disc diffusion method while the analysis of the different phytochemicals was carried out using standard methods. The result showed that the extract had inhibitory effects on the gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The effect of the extract was minimal on Staphylococcus aureus, a gram positive bacteria suggesting some degree of resistance by the organism. The result of the phytochemical screening showed that extract contains saponins, tannins, flavonoids and reducing sugars. The findings show that the plant bark extract has bactericidal activity and could be used in the control and treatment of bacterial infection especially the gram negative bacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

Uchenna¹,

Adaeze²,

Steve³

2015

JAS

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“…In addition, the ability of 3,5, 7-trihydroxyflavone (Fig. 4), to induce the damage of cytoplasmic membrane and subsequent loss of potassium supported the destruction pathway of MRSA [19] . By Keen observations on destruction pathways of MRSA we also noticed that isolated compounds are capable of interference with energy metabolism for the inhibition of oxygen consumption by MRSA [20] .…”

Section: Discussionmentioning

confidence: 80%

Bactericidal activity of Flavonoids isolated from Muntingia calabura

Gorripati¹,

Rajashekar²,

Dasu³

et al. 2018

IJLSSR

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The investigation was carried out for the isolation and characterization of the compounds from heart wood of root and root bark of Muntingia calabura. We have isolated six compounds, three from each extract and were identified as flavonoids. The bactericidal activity of these compounds found significant against tested bacterial strains. Among the tested compounds, 8-methoxy, 3ʹ,5ʹ7ʹ-trihydroxyflavone and 3,5,7-trihydroxyflavone (Galangin) showed paramount activity against MRSA. The results are compared with known standards gentamycin sulphate and cefixime.

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“…(Santos and Mello 2004). Synergism between flavonoids and antibiotics against resistant bacterial strains and the bacteriostatic or bactericidal activity of flavonols have been demonstrated by (Cushnie and Lamb 2005).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical prospecting, modulator and antibacterial activity of aminoglycosides of the extract and fractions of the Annona squamosa

Souza¹,

Fernandes²,

Tintino³

et al. 2013

Ethnobio Conserv

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The medicinal plants and natural products are products with a great scientific interest due their possible use like phytodrugs. In this context, the phytochemical composition and the antibacterial and antibiotic modulatory activity of the extract and fractions of Annona squamosa against Staphylococus aureus and Escherichia coli were performed. All natural products have not showed clinically relevant antibacterial activity, with MIC ≥ 1024 mg/mL. However, the extract combined with some aminoglycoside showed a synergistic effect against multiresistant strains E. coli 27 and S. aureus 358. Due these results, A. squamosa (Annonaceae) must be more studied to be used as a source of natural products with adjuvant potential to enhance the antibiotic activity, combating by this way the microbial antibiotic resistance.

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Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss

Cited by 129 publications

References 26 publications

Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

Phytochemical and Antimicrobial Properties of the Aqueous Ethanolic Extract of Saccharum officinarum (Sugarcane) Bark

Bactericidal activity of Flavonoids isolated from Muntingia calabura

Phytochemical prospecting, modulator and antibacterial activity of aminoglycosides of the extract and fractions of the Annona squamosa

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