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Cited by 28 publications
(19 citation statements)
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“…Experiments with 27 were important to carry out because prior studies demonstrated that PDT can work synergistically with microtubule-targeting drugs. 79 The results a IC 50 values determined using CYP3A4, CYP1A2, or CYP2C9 inhibitor screening kits (BioVision) following the manufacturer's protocols. Stock solutions of 4, 7, or 9 were prepared in MeCN, plated, and combined with assay buffer and irradiated with a blue LED light source (t irr = 20 min, λ irr = 460−470 nm, 56 J/cm 2 ) or left in the dark.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…Experiments with 27 were important to carry out because prior studies demonstrated that PDT can work synergistically with microtubule-targeting drugs. 79 The results a IC 50 values determined using CYP3A4, CYP1A2, or CYP2C9 inhibitor screening kits (BioVision) following the manufacturer's protocols. Stock solutions of 4, 7, or 9 were prepared in MeCN, plated, and combined with assay buffer and irradiated with a blue LED light source (t irr = 20 min, λ irr = 460−470 nm, 56 J/cm 2 ) or left in the dark.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…As is reported, PTX can induce mitotic arrest at the G2/M phase by preventing microtubules from disassembly. 53,54 Tubulin immunostaining assays were used to explore the anticancer mechanism of Co-PT NPs. As illustrated in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…These results substantiated previous observations that nanocarriers from PEGylated dendritic peptides could effectively decrease the cytotoxicity of chemotherapeutic agents and photosensitizers against cancer because of their high biocompatibility. [10,17] The effect of DOX encapsulation on the antitumor activity of PDPP@D was then investigated. Notably, the lowest viability was achieved at a molar ratio of 2:1 for Ppa to DOX in PDPP@D. The synergy of PDPP@D was quantified by calculating the combination index (CI) at different fraction affected (fa) values for each drug at the ratio of 2:1 (Figure 5C,D and Table S6, Supporting Information).…”
Section: Antitumor Effects Of Pdpp@dmentioning
confidence: 99%