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Cited by 27 publications
(16 citation statements)
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“…This should have application not only in enhancing oral BA via reductions in first pass metabolism (as exemplified in the current study) but also in the use of oral lymph directing glyceride prodrugs to facilitate targeted drug delivery to enhance treatment of diseases with possible lymphatic involvement such as HIV, cancer, organ failure, inflammatory and metabolic disease. Examples of the latter include 1) delivery of the antiviral lopinavir to HIV reservoirs in the mesenteric lymphatic system ( Qin et al, 2021 ); 2) delivery of the anticancer agent docetaxel to specific tumor tissues, with reduced gastrointestinal toxicity ( Tian et al, 2019 ); 3) delivery of a lymph directing prodrug of the immunomodulator mycophenolic acid to the mesenteric lymph nodes to enhance GI immunomodulation in an OVA-stimulated lymphocyte proliferation model ( Kochappan et al, 2021 ); 4) delivery of a lymph directed prodrug of the NSAID celecoxib to the mesenteric lymphatics and the adipose tissue surrounding the lymphatics to improve insulin resistance in obese high-fat-diet fed animals ( Cao et al, 2021 ) and the delivery of TG analogues of the natural antioxidant pterostilbene to adipose tissues ( Mattarei et al, 2017 ) and 5) delivery of lipase inhibitors to the mesenteric lymphatics to neutralise pancreatic lipases, that are released into the lymphatics in acute and critical illness ( Lee et al, 2021 ). Ongoing studies in our laboratories and others are exploring a range of approaches to enhance drug delivery and efficacy via the use of lymph-directing strategies.…”
Section: Discussionmentioning
confidence: 99%
“…This should have application not only in enhancing oral BA via reductions in first pass metabolism (as exemplified in the current study) but also in the use of oral lymph directing glyceride prodrugs to facilitate targeted drug delivery to enhance treatment of diseases with possible lymphatic involvement such as HIV, cancer, organ failure, inflammatory and metabolic disease. Examples of the latter include 1) delivery of the antiviral lopinavir to HIV reservoirs in the mesenteric lymphatic system ( Qin et al, 2021 ); 2) delivery of the anticancer agent docetaxel to specific tumor tissues, with reduced gastrointestinal toxicity ( Tian et al, 2019 ); 3) delivery of a lymph directing prodrug of the immunomodulator mycophenolic acid to the mesenteric lymph nodes to enhance GI immunomodulation in an OVA-stimulated lymphocyte proliferation model ( Kochappan et al, 2021 ); 4) delivery of a lymph directed prodrug of the NSAID celecoxib to the mesenteric lymphatics and the adipose tissue surrounding the lymphatics to improve insulin resistance in obese high-fat-diet fed animals ( Cao et al, 2021 ) and the delivery of TG analogues of the natural antioxidant pterostilbene to adipose tissues ( Mattarei et al, 2017 ) and 5) delivery of lipase inhibitors to the mesenteric lymphatics to neutralise pancreatic lipases, that are released into the lymphatics in acute and critical illness ( Lee et al, 2021 ). Ongoing studies in our laboratories and others are exploring a range of approaches to enhance drug delivery and efficacy via the use of lymph-directing strategies.…”
Section: Discussionmentioning
confidence: 99%
“…FaSSIF was prepared according to the literature [ 17 ]. The stability of TU in FaSSIF/ES was performed as described in the literature [ 18 , 19 ]. The reaction medium (1 mL) was incubated at 37 °C for 5 min prior to the experiment.…”
Section: Methodsmentioning
confidence: 99%
“…However, PK assessment concluded at 24 h, thus the sustainability of antiretroviral activity over a longer time could not be substantiated. Qin et al developed an alkyl ester prodrug library of lopinavir, loaded the prodrugs into artificial emulsions as well as chylomicrons, and delivered the nanoassemblies intravenously and orally to rats [ 125 ]. The group reported 7.2-fold higher drug levels in mesenteric lymph nodes as well as increased plasma half-lives of the various prodrugs.…”
Section: The Use Of Prodrugs For Infectious Diseasesmentioning
confidence: 99%