Drug delivery systems based on intrinsically conducting polymers

Puiggalı́-Jou, Anna; Valle, Luís J. del; Alemán, Carlos

doi:10.1016/j.jconrel.2019.07.035

Cited by 96 publications

(63 citation statements)

References 137 publications

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“…Over the past decades, the progress of nanotechnology has opened up new avenues for medical science, especially in the field of drug delivery. Traditional drug carriers have been developed based on liposomes/ lipids [1], polymers of synthetic and natural origin [2], and inorganic nanoparticles [3]. To make a clinical impact, nanoparticles for drug delivery must be biocompatible and biodegradable with minimal toxicity.…”

Section: Viral Nanocarrier Platformsmentioning

confidence: 99%

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Chung

Cai

Steinmetz

2020

Advanced Drug Delivery Reviews

248

199

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Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials derived from plant viruses, bacteriophages, and mammalian viruses. The application and development of VNPs and their genomefree versions, the virus-like particles (VLPs), for nanomedicine is a rapidly growing. VLPs can encapsulate a wide range of active ingredients as well as be genetically or chemically conjugated to targeting ligands to achieve tissue specificity. VLPs are manufactured through scalable fermentation or molecular farming, and the materials are biocompatible and biodegradable. These properties have led to a wide range of applications, including cancer therapies, immunotherapies, vaccines, antimicrobial therapies, cardiovascular therapies, gene therapies, as well as imaging and theranostics. The use of VLPs as drug delivery agents is evolving, and sufficient research must continuously be undertaken to translate these therapies to the clinic. This review highlights some of the novel research efforts currently underway in the VNP drug delivery field in achieving this greater goal.

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Section: Viral Nanocarrier Platformsmentioning

confidence: 99%

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Chung

Cai

Steinmetz

2020

Advanced Drug Delivery Reviews

248

199

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“…According to the frequency word range, the highest two bits of the selected 20-bit data were always "01", that was, from 0100 0001 1000 1001 0011 to 0110 1010 0111 1111 0000, so the frequency word only needed 18 lines, and the phase resolution required 0.1 degree. The phase resolution was 360/2 M , where M was the number of bits of the phase accumulator, so the phase accumulator was selected as 12 bits [3], and the actual resolution is 360/212 = 0.088 degrees. The specific block diagram was shown in figure 5.…”

Section: Dds Wave Form Generation Module Software Designmentioning

confidence: 99%

“…The parallel control module selected the MAX7547 and selected the state machine [3][4][5][6] to drive. The voltage signal after the conversion was used as the reference voltage of the serial D/A chip LTC1595.…”

Section: Parallel D/a Control Modulementioning

confidence: 99%

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The Design of Three Phase Programmable Testing Power Based on CPLD_DSP

Li¹,

Li²

2019

AWCN

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A design of three phases programmable testing power program-controlled based on CPLD_DSP was introduced in the paper. RAM was driven and six DDS were generated in CPLD. RAM was driven and six DDS (three voltage signal and three current signal) were generated in CPLD. The six DDS signal was used as based signal of testing power. CPLD was programmed to control serial D/A chip named LTC1595B to adjust the value of voltage and current. Voltage signal and current signal were collected and computed and closed loop by DSP. After testing, the output frequency resolution of the system achieved 0.001Hz.The voltage and current control precision achieved 0.02%.

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“…For example, we do not discuss organic small molecule devices, conjugated polymer nanoparticles for imaging or optical biosensing, [ 3–5 ] biomimicking neuromorphic designs, [ 6–8 ] hydrogen‐bond mediated bioprotonics, [ 9–11 ] or polymers for nonelectronic/ionic driven drug delivery. [ 12 ] We also include a brief discussion of the origin of bioelectricity itself, as this is fundamental to the motivation and application of many organic bioelectronic interfaces.…”

Section: Introductionmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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Conjugated polymers exhibit interesting material and optoelectronic properties that make them well‐suited to the development of biointerfaces. Their biologically relevant mechanical characteristics, ability to be chemically modified, and mixed electronic and ionic charge transport are captured within the diverse field of organic bioelectronics. Conjugated polymers are used in a wide range of device architectures, and cell and tissue scaffolds. These devices enable biosensing of many biomolecules, such as metabolites, nucleic acids, and more. Devices can be used to both stimulate and sense the behavior of cells and tissues. Similarly, tissue interfaces permit interaction with complex organs, aiding both fundamental biological understanding and providing new opportunities for stimulating regenerative behaviors and bioelectronic based therapeutics. Applications of these materials are broad, and much continues to be uncovered about their fundamental properties. This report covers the current understanding of the fundamentals of conjugated polymer biointerfaces and their interactions with biomolecules, cells, and tissues in the human body. An overview of current materials and devices is presented, along with highlighted major in vivo and in vitro applications. Finally, open research questions and opportunities are discussed.

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Drug delivery systems based on intrinsically conducting polymers

Cited by 96 publications

References 137 publications

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

The Design of Three Phase Programmable Testing Power Based on CPLD_DSP

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

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