Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11)

Self-Assembled Hyaluronate/Protamine Polyelectrolyte Nanoplexes: Synthesis, Stability, Biocompatibility and Potential Use as Peptide Carriers

“…Mini-pellets composed of HA/recombinant human interleukin 11 (rhIL11) and HA/PROT/rhIL11 were observed to enhance the in vivo efficacy of the cytokine, which was attributed to the interactions between HA and rhIL11. 14 A longer plasma residence time was measured for rhIL11 released from HA/PROT pellets, which was accompanied by an increase in pharmacologic efficacy. 14 Mok et al showed that a conjugate of HA and an anti-sense oligonucleotide used to form a nanocomplex with PROT was characterized by better cellular uptake compared with that of unconjugated physical complexes formed between PROT and naked oligonucleotides.…”

“…14 A longer plasma residence time was measured for rhIL11 released from HA/PROT pellets, which was accompanied by an increase in pharmacologic efficacy. 14 Mok et al showed that a conjugate of HA and an anti-sense oligonucleotide used to form a nanocomplex with PROT was characterized by better cellular uptake compared with that of unconjugated physical complexes formed between PROT and naked oligonucleotides. 15 We recently presented studies on the optimum formation condition and properties of crosslinker-and surfactant-free HA/chitosan NPs 4 and also showed that salmon calcitonin/ HA/chitosan NPs were able to reduce experimental inflammatory arthritis.…”

Formulation and Stability of Cytokine Therapeutics

“…In addition, future may show promise for combination products, such as a controlled‐release microparticle formulation with a mixture of IL‐2, transforming growth factor β and rapamycin, implicated for treatment of autoimmune diseases . For rhIL‐11, attempts to maximize the clinical potency and reduce the frequency of administration include developing a hyaluronic acid matrix for sustained release, pegylation, and site‐directed mutagenesis …”

Investigation of the swelling behavior of crosslinked hyaluronic acid films and hydrogels produced using homogeneous reactions

“…Hyaluronan (HA) is a member of a group of polysaccharides that have been termed “connective tissue polysaccharides,” “mucopolysaccharides,” or “glycosaminoglycans.” It is a linear, unbranched polymer composed of a repeating disaccharide that consists of N ‐acetyl‐ D ‐glucosamine (GlcNAc) and D ‐glucuronic acid (GlcA) linked by a β 1–4 glycosidic bond1 and is an attractive building block for new biocompatible and biodegradable polymers with possible applications in drug delivery,2 tissue engineering,3–5 and visco supplementation 6. Commercial HA is usually obtained from rooster comb and a procedure developed by Balazs et al was the first industrially applied extraction method for the isolation and purification of pharmaceutical grade material 7.…”