Clinic-pathological aspect of gastro-intestinal stromal tumors at tertiary care Hospital India

Abstract

Background This study defines the disease profile in south Indian population and determine the clinic-pathological aspects of Gastro-Intestinal Stromal Tumors. Method In this prospective study patients diagnosed of gastrointestinal stromal tumors were taken thorough clinical examination and a database of Anthropometric details and clinical details were analyzed. Pathological data included tumor size, presence or absence necrosis, mitotic counts, immunohistochemistry for CD-117, CD-34. Results There were 44 patients with confirmed diagnosis of gastro-intestinal stromal tumor. The highest incidence was found in the 6 th decade. The most common symptoms were abdominal pain and gastrointestinal bleed. Stomach was most frequent site for gastro-intestinal stromal tumors. Immunochemistry for CD-117 was positive in 93.18% cases. Majority of tumors (79.5%) had pure spindle cell morphology and mitotic activity showed that 34% of the GISTs were of the high risk group. Forty two patients were suggestive of surgery as the primary treatment after presentation. Conclusion Abdominal pain was the most common presenting complaint. Majority of the tumors aroused from the stomach. The majority of the tumors had pure spindle cell morphology and 93% of the tumors were CD-117 positive. A significant relationship between tumor size, tumor necrosis and mitotic activity with large tumors having necrosis and high mitotic rate having high risk of malignancy, was observed. Surgical resection is considered mainstay of treatment of gastro-intestinal stromal tumor. Imatinib therapy should be given to patients in moderate to severe risk categories.

Clinical significance of 18F-FDG PET/CT imaging in 32 cases of gastrointestinal stromal tumors

“…Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract. The pathological manifestations are spindle cells or epithelioid cells, and the histochemical characteristics are that the tumor is CD117, CD34, and DOG1 positive [1][2][3]. Due to the diversity and complexity of the biological behavior of GIST, it cannot be classified solely as benign or malignant; the risk of GIST biological behavior can be quickly and effectively judged by examining the patient's treatment plan and prognosis, as it is closely related to these [4,5].…”