“…6 ICA is a "luminogram" incapable of showing plaque, and is a 2-D representation of a complex 3-D structure, explaining why ICA can underestimate the real lesion severity. 21 Stone et al concluded that the lesions responsible for future major adverse cardiac events are mild as seen on angiography but severe on IVUS, the latter more accurately reflecting the true situation. 6,7, 21 In the present study the incidence rate of coronary events was higher in the patients with >25% residual luminal narrowing on ICA than in those without, with 540 of 676 patients having >25% residual luminal narrowing.…”