Enhanced photodynamic inactivation for Gram-negative bacteria by branched polyethylenimine-containing nanoparticles under visible light irradiation

Wang, Qian; Zhang, Dandan; Jin, Feng; Sun, Tairen; Li, Cailing; Xie, Xiaofeng; Shi, Qingshan

doi:10.1016/j.jcis.2020.09.106

Cited by 20 publications

(12 citation statements)

References 45 publications

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“…The localization of PSs to target microorganisms depends on many factors, such as the molecular size, charge, lipophilicity, concentration of PSs, and cell wall structure of the target microorganisms [ 26 ]. Weak interactions between PSs and Gram-negative bacteria limit the application of APDT [ 144 ]. The outer membrane of Gram-negative bacteria comprises an asymmetric bilayer consisting of phospholipids and lipopolysaccharides.…”

Section: Current Limitations Of Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Polat

Kang

2021

Biomedicines

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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Section: Current Limitations Of Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Polat

Kang

2021

Biomedicines

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“…They targeted the ecotoxicity of NMs in the air in terms of atmospheric pollution and antimicrobial activities by using ecotoxicological models of bees, lichens, and bacteria (for further details, see Supplementary Table S2 ). Overall, NMs can be internalized in lichens by inducing physiological changes, they can reduce oxidative stress through the gene expression of antioxidative enzymes and changes in the redox state of the cells in bees, or enhance the photodynamic inactivation for Gram-negative bacteria under visible light irradiation [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Nanomaterial Ecotoxicology in the Terrestrial and Aquatic Environment: A Systematic Review

Gambardella

Pinsino

2022

Toxics

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This systematic review analyzes the studies available on the ecotoxicity of nanomaterials (NMs) in the environment to understand where future research should be addressed for achieving Agenda 2030 goals on sustainable development and environmental safety. We discuss the status of NMs ecotoxicological effects across different organisms that are representative of all natural environments (land, air, water). A total of 1562 publications were retrieved from the Web of Science (all databases) by using the search criteria “nanomaterials” and “ecotoxicology”; among them, 303 studies were included in the systematic review because they met any of the following criteria: (i) focalize on both search criteria; (ii) deal with terrestrial, or aquatic environment; (iii) address models (organisms, cells) for the nano environmental risk assessment and exposure. The knowledge gaps are identified together with novel insights that need to be further investigated to better understand the ecotoxicological environmental impacts of NMs.

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“…2 a–d). In cross-linking and self-assembly-based encapsulation, the PSs were blended with a polymeric reaction mixture and physically entrapped inside the matrix through various interactions, including electrostatic, hydrogen bonding, and hydrophobic interactions [ 66 , 67 ]. In certain formulations, the PSs were also covalently linked with monomers to polymerize into composites [ 68 ].…”

Section: Polymeric Compositesmentioning

confidence: 99%

“…The ionic gelation process was adopted to encapsulate with chloroaluminium phthalocyanine (ClAlPc) in CS NPs, which exhibited a significant PDI effect on Streptococcus mutans ( S. mutans ) biofilm compared to free ClAlPc [ 76 ]. Moreover, the Ce6-loaded amphiphilic octanoyl chloride (OC)-functionalized PEI (OC-PEI) polymeric micelle also showed improved PDI action compared to free Ce6 [ 77 ].…”

Section: Polymeric Compositesmentioning

confidence: 99%