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Cited by 89 publications
(35 citation statements)
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References 194 publications
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“…CT‐membrane interactions have been studied extensively, both for the possibility of physiological relevance via pore formation, and for the increasing prevalence of lipid‐based delivery options for therapies ,,,. As with other amyloid peptides, CT preferentially interacts with membranes containing anionic lipids, cholesterol, and GM1 ganglioside ,,,,,,.…”
Section: Structural Studies On Calcitonin Aggregationmentioning
confidence: 99%
“…CT‐membrane interactions have been studied extensively, both for the possibility of physiological relevance via pore formation, and for the increasing prevalence of lipid‐based delivery options for therapies ,,,. As with other amyloid peptides, CT preferentially interacts with membranes containing anionic lipids, cholesterol, and GM1 ganglioside ,,,,,,.…”
Section: Structural Studies On Calcitonin Aggregationmentioning
confidence: 99%
“…Liposomes, the oldest nanocarrier systems, are spherical vesicles composed of at least one phospholipid bilayer, which encloses an aqueous core. [102] They could act as advanced nanodelivery systems for a wide range of drugs. [100] Liposomes are biodegradable and biocompatible vehicles with the ability to compartmentalize and solubilize hydrophilic, hydrophobic and also amphiphilic materials.…”
Section: Lipid-based Ddsmentioning
confidence: 99%
“…Liposomes are mainly created from naturally derived phospholipids, for example phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine. [102,104] However, cholesterol probably increases bilayer thickness to reduce the affinity of the peptide to the bilayer, resulting in a reduction in the ability for drug entrapment. However, "first-generation" liposomes have a number of disadvantages, such as a natural tendency to be preferentially rapidly captured by the reticuloendothelial system in the liver and spleen, as well as reduce the concentration of the drug in other potential sites.…”
Section: Lipid-based Ddsmentioning
confidence: 99%
“…18 LNCs are biomimetic nanocarriers obtained by the phase inversion temperature method. 19 LNCs have been widely studied as carriers for lipophilic compounds. 20,21 Our recent study showed that LNCs are capable of effectively adsorbing peptides, including AP114.…”
Section: Introductionmentioning
confidence: 99%
“…The most common cosurfactant is lecithin. [18][19][20]25 The macrogol 15 hydroxystearate/triglycerides mass mixing ratio (MMR) of 0.82 was selected as this is the ratio present in the most commonly described LNCs. 18,21 A previous study has shown that it is the monolaurin that makes the LNCs active against Gram-positive bacteria.…”
mentioning
confidence: 99%