Chitosan-dibasic orthophosphate hydrogel: A potential drug delivery system

Ta, Hang T.; Han, Han; Larson, Ian; Dass, Crispin R.; Dunstan, Dave E.

doi:10.1016/j.ijpharm.2009.01.018

Cited by 64 publications

(41 citation statements)

References 27 publications

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“…The fact that chitosan is highly biocompatible, biodegradable, and shows the ability to open intercellular tight junctions renders it an almost ideal candidate for formulating drugs for oral delivery (Berradaa et al, 2005). For example, a chitosan-dibasic orthophosphate hydrogel has been formulated and synthesized (Ta et al, 2009). The potential of employing this gel as a prolonged drug delivery vehicle was demonstrated using fluorescein isothiocyanate-dextran, β-lactoglobulin and bovine serum albumin.…”

Section: Pharmaceutical Applications Of Chitosan and Nanoparticlesmentioning

confidence: 99%

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

Gao¹,

Lai²,

Leung³

2012

Front. Physio.

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As a biomaterial, chitosan has been widely used in tissue engineering, wound healing, drug delivery, and other biomedical applications. It can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make chitosan an almost ideal biomaterial in cell culture applications, and cell cultures arguably constitute the most practical way to evaluate biocompatibility and biotoxicity. The advantages of cell cultures are that they can be performed under totally controlled environments, allow high throughput functional screening, and are less costly, as compared to other assessment methods. Chitosan can also be modified into multilayer composite by combining with other polymers and moieties to alter the properties of chitosan for particular biomedical applications. This review briefly depicts and discusses applications of chitosan and nanoparticles in cell culture, in particular, the effects of chitosan and nanoparticles on cell adhesion, cell survival, and the underlying molecular mechanisms: both stimulatory and inhibitory influences are discussed. Our aim is to update the current status of how nanoparticles can be utilized to modify the properties of chitosan to advance the art of tissue engineering by using cell cultures.

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Section: Pharmaceutical Applications Of Chitosan and Nanoparticlesmentioning

confidence: 99%

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

Gao¹,

Lai²,

Leung³

2012

Front. Physio.

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“…This polymer presents excellent biocompatibility, biodegradability and antimicrobial activity [3]. Thus, CHT has been studied for many medical applications such as tissue engineering and drug delivery systems [1][2][3][4][5][6]. As the CHT possesses higher adsorption capacity than chitin, therefore, the CHT-based materials could be utilized in water purification systems [7].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

Martins

Oliveira

Pereira

et al. 2012

International Journal of Biological Macromolecules

143

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This work deals with the preparation of chitosan/tripolyphosphate microparticles (CHT/TPP) using microemulsion system based on water/benzyl alcohol. The morphology of the microparticles was evaluated by scanning electron microscopy (SEM). The microparticles were also characterized through infrared spectroscopy (FTIR) and wide-angle X-ray scattering (WAXS). The morphology and crystallinity of microparticles depended mainly on CHT/TPP ratio. Studies of controlled release of HP were evaluated in distilled water and in simulated gastric fluid. Besides, the profile of HP releasing could be tailored by tuning the CHT/TPP molar ratio. Finally, these prospective results allow the particles to be employed as site-specific HP controlled release system.

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“…Size selectivity of the microgels is further analyzed using a set of fluorescently labeled dextran molecules with different molecular weights (Mw). The uncharged microgels prepared without AA and AAm are permeable to the dextran with Mw 10 000 g mol −1 and impermeable to that with Mw 20 000 g mol −1 so that cut‐off threshold is in between 5 and 7 nm, as shown in Figure S4a in the Supporting Information; hydrodynamic diameters of the dextran molecules are 5 and 7 nm, respectively . The positively charged microgels adsorb the dextran with Mw 10 000 g mol −1 in the inner matrix as the dextran is negatively charged, as shown in Figure S4b in the Supporting Information; the concentration of the dextran in the microgel is much higher than that in the surrounding.…”

Section: Resultsmentioning

confidence: 98%

SERS‐Active‐Charged Microgels for Size‐ and Charge‐Selective Molecular Analysis of Complex Biological Samples

Kim

Park

Kim

et al. 2018

Small

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Surface-enhanced Raman scattering (SERS) provides a dramatic increase of Raman intensity for molecules adsorbed on nanogap-rich metal nanostructures, serving as a promising tool for molecular analysis. However, surface contamination caused by protein adsorption and low surface concentration of small target molecules reduce the sensitivity, which severely restricts the use of SERS in many applications. Here, charged microgels containing agglomerates of gold nanoparticles (Au NPs) are designed using droplet-based microfluidics to provide a reliable SERS substrate with molecular selectivity and high sensitivity. The limiting mesh size of hydrogel enables the autonomous exclusion of large proteins and the charged matrix concentrates oppositely charged small molecules through electrostatic attraction. As nanogaps among Au NPs in the agglomerates enhance Raman intensity, Raman spectrum of the adsorbed molecules is selectively measured with high sensitivity in the absence of interruption from adhesive proteins. Therefore, the SERS-active-charged microgels can be used for direct analysis of pristine biological samples without the pretreatment steps of separation and concentration, which are commonly a prerequisite for Raman analysis. For the purpose of demonstration, a direct detection of fipronil sulfone with partial negative charges, a metabolite of toxic insecticide, dissolved in eggs using the positively charged microgels without any pretreatment of the samples, is shown.

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Chitosan-dibasic orthophosphate hydrogel: A potential drug delivery system

Cited by 64 publications

References 27 publications

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

Functional enhancement of chitosan and nanoparticles in cell culture, tissue engineering, and pharmaceutical applications

Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

SERS‐Active‐Charged Microgels for Size‐ and Charge‐Selective Molecular Analysis of Complex Biological Samples

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