The Aedes aegypti glutathione transferase family

Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation

“…This GST class is represented at least by eight members in the mosquitoes: GSTE1, GSTE2, GSTE3, GSTE4, GSTE5, GSTE6, GSTE7 and GSTE8 (Ding et al 2003). In this protein superfamily, there is one specific enzyme, the GSTE2 that has been associated with the resistance to chemical insecticides on the mosquitoes Anopheles gambiae and Aedes aegypti, respectively the main malaria and dengue fever vectors (David et al 2005;Lumjuan et al 2007). The GSTE2 aminoacid sequence is available for both the species (Ding et al 2003;Lumjuan et al 2007), but only the An.…”

Do Gastroenterologists Consider Aflatoxins as Origin of Digestive System Cancers?

“…GSH is an important antioxidant in plants, animals, fungi and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species, such as free radicals, peroxides, lipid peroxides and heavy metals [99].…”

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“…El rol principal de GST en la resistencia a organofosforados, es la detoxificación, que se realiza mediante una reacción de conjugación de la molécula con GSH dando como resultado la O-desalquilación y O-desarilacion (Lumjuan et al, 2007).…”

“…Se detectaron diferencias en la Based in the sequence N-terminal of amino acids, phylogenetic relation and substrate specificity of substrate (Umasuthan et al, 2012;Liu et al, 2015), the GSTs are embraced in three independent families: cytosolic, microsomal and mitochondrial Lumjuan et al, 2007;Iriarte et al, 2012;Umasuthan et al, 2012), and there are 14 classes called: alpha, beta, delta, epsilon, zeta, theta, kappa, lambda, mu, pi, sigma, tau, phi and omega.…”

“…In insects, six types of cytosolic GSTs have been found: delta, epsilon, sigma, omega, zeta and theta (Lumjuan et al, 2007;Hu et al, 2014;Hu et al, 2015) (Sheehan et al, 2001;Enayati et al, 2005;Lumjuan et al, 2007;Yu et al, 2008;Deng et al, 2009;Hu et al, 2014;Hu et al, 2015), from which delta and epsilon are specific for the insect class.…”