Effectiveness of a home-based therapeutic exercise program on lower back pain and functionality in Sickle Cell Disease (SCD) patients

Zanoni, Camila Tatiana; Galvão, Fábio; Maria, Renata Manzano; Zulli, Roberto; Ricciardi, Janaina Bosso da Silva; Cliquet, Alberto; Saad, Sara Teresinha Olalla

doi:10.1016/j.htct.2020.05.004

Cited by 2 publications

(1 citation statement)

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“…A pilot RCT of 10 adults with SCD indicated conventional physical therapy and aquatic physical therapy were acceptable and lead to reduced SCD pain (189), and a 2-arm nonrandomized clinical trial indicated a home-based therapeutic exercise program led to reductions in SCD pain (190).…”

Section: Physical Therapymentioning

confidence: 99%

Precision, integrative medicine for pain management in sickle cell disease

Smith,

Valrie,

Jaja

et al. 2023

Front. Pain Res.

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Sickle cell disease (SCD) is a prevalent and complex inherited pain disorder that can manifest as acute vaso-occlusive crises (VOC) and/or chronic pain. Despite their known risks, opioids are often prescribed routinely and indiscriminately in managing SCD pain, because it is so often severe and debilitating. Integrative medicine strategies, particularly non-opioid therapies, hold promise in safe and effective management of SCD pain. However, the lack of evidence-based methods for managing SCD pain hinders the widespread implementation of non-opioid therapies. In this review, we acknowledge that implementing personalized pain treatment strategies in SCD, which is a guideline-recommended strategy, is currently fraught with limitations. The full implementation of pharmacological and biobehavioral pain approaches targeting mechanistic pain pathways faces challenges due to limited knowledge and limited financial and personnel support. We recommend personalized medicine, pharmacogenomics, and integrative medicine as aspirational strategies for improving pain care in SCD. As an organizing model that is a comprehensive framework for classifying pain subphenotypes and mechanisms in SCD, and for guiding selection of specific strategies, we present evidence updating pain research pioneer Richard Melzack’s neuromatrix theory of pain. We advocate for using the updated neuromatrix model to subphenotype individuals with SCD, to better select personalized multimodal treatment strategies, and to identify research gaps fruitful for exploration. We present a fairly complete list of currently used pharmacologic and non-pharmacologic SCD pain therapies, classified by their mechanism of action and by their hypothesized targets in the updated neuromatrix model.

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Section: Physical Therapymentioning

confidence: 99%