Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

Chagas, Pablo Ferreira das; Sousa, Graziella Ribeiro de; Kodama, Márcio Hideki; Biagi, Carlos Alberto Oliveira de; Yunes, José Andrés; Brandalise, Sílvia Regina; Calin, George A.; Tone, Luíz Gonzaga; Scrideli, Carlos Alberto; Oliveira, Jaqueline Carvalho de

doi:10.1016/j.htct.2019.12.003

Cited by 15 publications

(5 citation statements)

References 35 publications

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“…T-ALL is usually more associated with poor prognosis when compared to B-ALL. Uc.112 was found more expressed in this group of patients, but, considering only B-ALL, Uc.112 was highly expressed in hyperdiploidy patients, a group considered as low risk of recurrence among B-ALL ( das Chagas et al, 2021 ).…”

Section: Introductionmentioning

confidence: 66%

Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

Oliveira

2023

Genet. Mol. Biol.

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The ultraconserved regions (UCRs) are 481 genomic elements, longer than 200 bp, 100% conserved in human, mouse, and rat genomes. Usually, coding regions are more conserved, but more than 80% of UCRs are either intergenic or intronic, and many of them produce long non-coding RNAs (lncRNAs). Recently, the deregulated expression of transcribed UCRs (T-UCRs) has been associated with pathological conditions. But, differently from many lncRNAs with recognized crucial effects on malignant cell processes, the role of T-UCRs in the control of cancer cell networks is understudied. Furthermore, the potential utility of these molecules as molecular markers is not clear. Based on this information, the present review aims to organize information about T-UCRs with either oncogenic or tumor suppressor role associated with cancer cell signaling, and better describe T-UCRs with potential utility as prognosis markers. Out of 481 T-UCRs, 297 present differential expression in cancer samples, 23 molecules are associated with tumorigenesis processes, and 12 have more clear potential utility as prognosis markers. In conclusion, T-UCRs are deregulated in several tumor types, highlighted as important molecules in cancer networks, and with potential utility as prognosis markers, although further investigation for translational medicine is still needed.

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Section: Introductionmentioning

confidence: 66%

Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

Oliveira

2023

Genet. Mol. Biol.

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“… 22 LINC00265 and SPRY4-IT1 are highly expressed as oncogenes, whereas TRIM52-AS1 and BX357664 have low expression levels as tumor suppressors involved in tumorigenesis. 18 , 23 , 24 The lncRNA uc.112 is highly expressed in ALL as an oncogene, 25 and TCL6 as a tumor suppressor in ALL can significantly increase disease-free survival in “TCL6 high” patients compared with “TCL6 low” patients. 26 As far as we know, LINC00265 has not been explored in ALL.…”

Section: Discussionmentioning

confidence: 99%

LINC00265/miR-4500 Axis Accelerates Acute Lymphoblastic Leukemia Progression by Enhancing STAT3 Signals

Zhao¹,

Xing²,

Song³

et al. 2021

CMAR

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Background Long noncoding RNA LINC00265 or miR-4500 is involved in the pathogenesis of many cancers. However, their functions in acute lymphoblastic leukemia (ALL) remain unknown. In this study, we investigated how LINC00265 and miR-4500 regulate the malignant characteristics of ALL. Methods Real-time PCR was used in examining the expression of LINC00265 in ALL cell lines and blood of patients with ALL. Cell proliferation, cell migration, and xenograft tumor assays were performed to verify the function of LINC00265 subjected to overexpressing and silencing experiments. The ceRNA mechanism with LINC00265/miR-4500/STAT3 was investigated through luciferase and RNA pull-down assays. Finally, the function of the LINC00265/miR-4500/STAT3 axis subjected to overexpressing and silencing assays was determined through cell proliferation, cell migration, and xenograft tumor assays. Results LINC00265 was highly expressed in ALL cell lines and blood of patients with ALL and facilitated the proliferation, migration, invasion, and growth of xenograft tumors of ALL cells. The silencing of LINC00265 expression with LINC00265 siRNA significantly inhibited the malignancy of the ALL cells. RNA pull-down and luciferase assays demonstrated that LINC00265 competitively targeted miR-4500 and enhanced STAT3 expression. Furthermore, miR-4500 inhibitors or overexpressed LINC00265 up-regulated STAT3 expression, and miR-4500 mimics or STAT3 shRNAs eliminated the LINC00265-induced malignancy of the ALL cells. Conclusion Mechanistically, LncRNA LINC00265 can competitively interact with miR-4500 and thereby up-regulates STAT3 signaling and enhances the malignancy of tumors.

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“…Among them, the uc.112 was identified as over-expressed in pediatric T cell acute lymphoblastic leukemia (T-ALL), suggesting a potential role of T-UCR in pediatric leukemia. 101 Similarly, uc.8+, identified as the most over-expressed in bladder cancer and correlated with tumor grading and staging, has been reported to act as decoy for miR-596 causing the up-regulation of MMP9, which improves the invasive potential of bladder cancer cells. 102 Notably, uc.8+ localizes both in the cytoplasm and nucleus in the early stages, whereas in advanced bladder cancer has a prevalent cytoplasmic localization, suggesting to use its subcellular location for prognostic purposes.…”

Section: Lncrnas With Oncogene-like Propertiesmentioning

confidence: 99%

“…Since the pioneer work of Calin and colleagues in 2007 98 —reporting evidence that most of these regions were transcribed—T‐UCRs expression has been identified as altered in many human cancers, and oncogene‐like properties have been described in multiple tumors. Among them, the uc.112 was identified as over‐expressed in pediatric T cell acute lymphoblastic leukemia (T‐ALL), suggesting a potential role of T‐UCR in pediatric leukemia 101 . Similarly, uc.8+, identified as the most over‐expressed in bladder cancer and correlated with tumor grading and staging, has been reported to act as decoy for miR‐596 causing the up‐regulation of MMP9 , which improves the invasive potential of bladder cancer cells 102 .…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Emerging role of oncogenic long noncoding RNA as cancer biomarkers

Aprile

Costa

Cimmino

et al. 2022

Intl Journal of Cancer

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The view of long noncoding RNAs as nonfunctional "garbage" has been definitely outdated by the large body of evidence indicating this class of ncRNAs as "golden junk", especially in precision oncology. Indeed, in light of their oncogenic role and the higher expression in multiple cancer types compared with paired adjacent tissues, the clinical interest for lncRNAs as diagnostic and/or prognostic biomarkers has been rapidly increasing. The emergence of large-scale sequencing technologies, their subsequent diffusion even in small research and clinical centers, the technological advances for the detection of low-copy lncRNAs in body fluids, coupled to the huge reduction of operating costs, have nowadays made possible to rapidly and comprehensively profile them in multiple tumors and large cohorts. In this review, we first summarize some relevant data about the oncogenic role of well-studied lncRNAs having a clinical relevance. Then, we focus on the description of their potential use as diagnostic/prognostic biomarkers, including an updated overview about licensed patents or clinical trials on lncRNAs in oncology.

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Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

Cited by 15 publications

References 35 publications

Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers

LINC00265/miR-4500 Axis Accelerates Acute Lymphoblastic Leukemia Progression by Enhancing STAT3 Signals

Emerging role of oncogenic long noncoding RNA as cancer biomarkers

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