Splenic hamartoma associated with visceral leishmaniasis mimicking aggressive lymphoma

Oliveira, Leonardo Rodrigues de; Borges, Carla Oranges; Meneses, Antônio Carlos de Oliveira

doi:10.1016/j.htct.2019.08.002

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2022

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“…Partly because of the low frequency and morphologic overlap between these lesions, it is difficult to distinguish from each other. Some authors observed that SANT were often accompanied with primary splenic lesions including splenic hamartoma 3,11,12 , inflammatory pseudotumor 13,14 , hemangioma 15,16 . Thus, they presumed that SANT was developed from those tumors.…”

Section: Discussionmentioning

confidence: 99%

Clonality analysis of Sclerosing Angiomatoid Nodular Transformation in Spleen

Han

Chen³

et al. 2022

Preprint

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Aims: Use clonality study to detect sclerosing angiomatoid nodular transformation (SANT) of the spleen and to explore the essence and pathogenesis of SANT.Methods: All SANT cases was performed by clonality analysis and in situ hybridization for the presence of EBV encoded small RNAs (EBER). Immunohistochemisty were used to classify the character of SANT, hemangioma. Results: The results of histological and immunohistochemical detection show the obstruction of arterioles and the passive congestion of venules in red pulp might participate in the formation of SANT. The results of clonality analysis show polyclonality was demonstrated in SANT nodules and the surrounding spleen parenchyma.Conclusion: SANT is a benign proliferative lesion. Combined with the immunohistochemisty, clonality analysis can be an useful tool for differential diagnosis of these splenic lesions.

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