Reference intervals of the platelet indexes in a healthy population in Santa Maria, Rio Grande do Sul, Brazil

Pereira, Karla Nunes; Carvalho, José Antônio Mainardi de; Paniz, Clóvis

doi:10.1016/j.htct.2018.08.004

Cited by 1 publication

(1 citation statement)

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“…The platelet RI study conducted on the UK population by the Ali U et al reported that there is a significant difference in platelet indices RI between sexes [ 48 ]. Consistent with this finding, we also observed insignificant differences only for PDW; however, variable observations between sexes were also published [ 45 , 49 ]. The leukocyte counts are reported to be higher in females than males and they reverse in old age [ 46 , 50 ].…”

Section: Discussionsupporting

confidence: 92%

Routine clinical chemistry and haematological test reference intervals for healthy adults in the Bhutanese population

Dorji¹,

ChhodenR

Wangchuk³

et al. 2022

PLoS ONE

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Laboratory medicine plays a critical role in the modern healthcare system, and it is reported to influence 60–70% of clinical decision makings. The quantitative laboratory test results are interpreted by comparing to the Reference Intervals (RIs) and therefore the use of appropriate RIs is critical. Clinical laboratories in Bhutan have been randomly using RIs from textbooks and manufacturer’s package inserts without even verifying their applicability and therefore lessening their contribution to clinical decision makings. To improve the healthcare service delivery in Bhutan, this study aims to establish routine clinical chemistry and haematological test RIs for healthy adults in the Bhutanese population. Out of 1150 (male, n = 570; female, n = 580) healthy Bhutanese adults listed for the study through a simple random sampling technique, 1002 (male, n = 405; female, n = 597) individuals were assessed and 815 (male, n = 372; female, n = 443) individuals were enrolled in the study. An adequate volume of venous blood was drawn from these participants with the use of standard phlebotomy technique for clinical chemistry and haematological analysis. The laboratory data were analysed with the use of statistical methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine and Clinical and Laboratory Standards Institute. After excluding the test results indicating underlying pathology and statistically detected outliers, a maximum of 775 (male, n = 346; female, n = 429) and 784 (male, n = 351; female, n = 433) individuals test values were eligible for clinical chemistry and haematology RIs establishment respectively. Statistically, there were no significant differences between age groups of same-sex for both test categories; however, significant differences between sex were observed for various test parameters in both test categories. Our RIs are generally comparable to other published literature. The established RIs are applicable to all the adult Bhutanese population; however, clinical laboratories should validate the transference of these RIs before using them for clinical purposes.

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Section: Discussionsupporting

confidence: 92%