Seroprevalence of Chikungunya virus in blood donors from Northern and Southeastern Brazil

Slavov, Svetoslav Nanev; Otaguiri, Katia Kaori; Bianquini, Melina Lellis; Bitencourt, Hellen Tayaná; Guerreiro, Domingos Sávio de Souza; Figueiredo, Luíz Tadeu Moraes; Covas, Dimas Tadeu; Kashima, Simone

doi:10.1016/j.htct.2018.04.002

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The present report draws attention to the fact that CHIKV seems to have had a particular impact on the Fulni-ô people, the least urbanized Indigenous group in the Northeast Region of Brazil, showing more than 70% seroprevalence, in contrast to the absence of anti-CHIKV IgG in the Truká tribe. This significant and unexpected result in the Fulni-ô tribe differs from most epidemiological studies in the Americas, where estimated and found prevalence has been less than 50% [28][29][30]. To date, few studies have recorded such high prevalences.…”

Section: Discussioncontrasting

confidence: 65%

Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil

et al. 2021

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Background Chikungunya fever (CHIKF) is a serious public health problem with a high rate of infection and chronic disabling manifestations that has affected more than 2 million people worldwide since 2005. In spite of this, epidemiological data on vulnerable groups such as Indigenous people are scarce, making it difficult to implement public policies in order to prevent this disease and assist these populations. Objective To describe the serological and epidemiological profile of chikungunya virus (CHIKV) in two Indigenous populations in Northeast Brazil, as well as in an urbanized control community, and to explore associations between CHIKV and anthropometric variables in these populations. Methodology/Principal findings This is a cross-sectional ancillary study of the Project of Atherosclerosis among Indigenous Populations (PAI) that included people 30 to 70 years old, recruited from two Indigenous tribes (the less urbanized Fulni-ô and the more urbanized Truká people) and an urbanized non-Indigenous control group from the same area. Subjects underwent clinical evaluation and were tested for anti-CHIKV IgG by enzyme-linked immunosorbent assay. Serological profile was described according to ethnicity, sex, and age. The study population included 433 individuals distributed as follows: 109 (25·2%) Truká, 272 (62·8%) Fulni-ô, and 52 (12%) from the non-Indigenous urbanized control group. Overall prevalence of CHIKV IgG in the study sample was 49.9% (216; 95% CI: 45·1–54·7). When the sample was stratified, positive CHIKV IgG was distributed as follows: no individuals in the Truká group, 78·3% (213/272; 95% CI: 72·9–83·1) in the Fulni-ô group, and 5.8% (3/52; 95% CI: 1.21–16) in the control group. Conclusions/Significance Positive tests for CHIKV showed a very high prevalence in a traditional Indigenous population, in contrast to the absence of anti-CHIKV serology in the Truká people, who are more urbanized with respect to physical landscape, socio-cultural, and historical aspects, as well as a low prevalence in the non-Indigenous control group, although all groups are located in the same area.

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Section: Discussioncontrasting

confidence: 65%

Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil

et al. 2021

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“…6 Asymptomatic CHIK poses a substantial threat to transfusion. 8,25 The current study recorded two positive low blood donor samples by qRT-PCR without positive IgM response, presumably from the initial phase of viremia and likely to be infectious. Whole-genome sequencing attempts were unsuccessful, 26 likely due to low virus concentration.…”

mentioning

confidence: 72%

Seroprevalence of Chikungunya in an Asymptomatic Adult Population in North and South Sulawesi, Indonesia

Jalloh

Artika

Dewi

et al. 2023

The American Journal of Tropical Medicine and Hygiene

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Chikungunya (CHIK) is an emerging and reemerging infectious disease of public health importance in Indonesia. Information on the asymptomatic and true burden of CHIK virus (CHIKV) infections is limited. We assayed 1,092 healthy population samples, collected in North and South Sulawesi between 2019 and 2020, for antibodies against CHIKV. Blood samples were screened by IgM and IgG ELISAs and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay. CHIKV IgG seroprevalence in North and South Sulawesi was 53.2% and 53.9%, respectively. The overall prevalence of anti-CHIKV IgM antibody was 12.9%. Molecular testing of blood donors revealed 0.66% (2/300) were positive for CHIKV qRT-PCR. Our study provides new insights into the CHIKV endemicity situation in the eastern part of Indonesia and warrants the need for further systematic surveillance considering there is no treatment or vaccine for CHIK infection.

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“…14 Cases of DENV transmission via blood transfusion have been documented, and CHIKV has the potential to be transmitted via this route. 15,16 Further, there is evidence for DENV-related fetal congenital defects, though sexual transmission has not been documented. 17 Recipients with positive post-transfusion serology results had their pretransfusion samples tested for virus-specific IgM and IgG by ELISA and for viral RNA by real-time PCR.…”

Section: Laboratory Testingmentioning

confidence: 99%

No Observed Risk of Pregnancy and Maternal-Fetal Transmission of Zika Virus Following Blood Transfusion

DeGiorgi

Tan

Fowler

et al. 2019

Preprint

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BACKGROUND: Zika virus (ZIKV) is primarily mosquito-borne, but can also be transfusion- and sexually transmitted. Maternal-fetal transmission may result in fetal loss or severe congenital defects. METHODS: We surveyed blood recipients enrolled in a donor-recipient-linked study of transfusion-transmitted infections to assess potential risk of ZIKV maternal-fetal transmission following transfusion. Participants were tested for antibodies to ZIKV, dengue and chikungunya viruses. Positive serology from post- and pre-transfusion samples and from linked donors were tested using real-time PCR. RESULTS: The mean age of female recipients was 65 years (36-80). Only one was < 50 years. None reported having sexual intercourse within the first month and none became pregnant within six months following transfusion. Male recipients were a mean 62 years of age (31-81). Twenty percent of males had sexual intercourse with a female partner within three months of transfusion; no pregnancies resulted. Females and males most commonly reported that they were no longer sexually active or felt too ill after transfusion. All of the respondents were IgM and RT-PCR negative. CONCLUSIONS: Our survey of blood recipients, combined with derived data and the literature, suggest that most transfused women are beyond the age of likely pregnancy and most transfused women and men are too infirm from the underlying condition to engage in sex. However, 20% of male recipients did report having sexual intercourse during the ZIKV infectious period.

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Seroprevalence of Chikungunya virus in blood donors from Northern and Southeastern Brazil

Cited by 4 publications

References 15 publications

Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil

Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil

Seroprevalence of Chikungunya in an Asymptomatic Adult Population in North and South Sulawesi, Indonesia

No Observed Risk of Pregnancy and Maternal-Fetal Transmission of Zika Virus Following Blood Transfusion

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