Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Inflammatory Bowel Disease (IBD) refers to conditions characterized by the presence of idiopathic intestinal inflammation. The main challenge in the management of IBD is the adverse effects associated with the currently available drugs. Also, not all patients respond completely to the conventional treatments of IBD and its efficacy wanes over time. Thus, the use of complementary and alternative medicine is increasing, as a safer alternative. Certain traditional Ayurveda literature of Kerala describe a condition termed ‘jatara vrana’ (ulcer of the gastrointestinal tract), which, along with its associated clinical features, resembles IBD. Due to the similarity in pathology and presenting features, the line of treatment adopted in the management of jatara vrana may be extended to that of IBD. A close observation of the formulations described in the management of jataravrana described in Chikitsamanjari (a regional Ayurvedic literature of Kerala) reveals that in each formulation individual drugs with varying mechanisms of action, including anti-ulcerative (vranaropana), anti-diarrheal (atisaraghna), anti-inflammatory (sophahara), anti-pyretic (jwarahara) or analgesic (vedanahara) activities, have been logically selected and combined. The active components of some of these drugs have been proven to have various effects in IBD pathology. Though these treatment principles have been used traditionally and Ayurvedic management is promising in many experimental models, it is essential to supplement it with well-designed clinical trials to define the exact role of each of these formulations in the prevention or management of IBD.

show abstract

Novel Iboga-derivatives Modulate Nociception and Inflammation in Acute Mouse Pain Model

Bhattacharya

Gupta

et al. 2023

Preprint

View full text Add to dashboard Cite

The present study explored efficient and exclusive analgesic effects of iboga-analogs in formalin-induced mouse via acute pain model. Novel iboga derivatives namely iboga-alcohol, iboga-amide, iboga-methylamide and iboga ester-exo were administered intraperitoneally to evaluate the anti-nociceptive, anti-inflammatory and neuromodulatory effects. Pain assessment was done by paw diameter, paw licking and tail immersion tests. Locomotor activity and anxiety-like behavior were determined by open field test and elevated plus maze. Inflammatory mediators, neurotransmitters and neurotrophic factors were measured from isolated serum, paw tissue and spinal segment. Iboga-analogs significantly reduced paw diameters. Decreased tail flick latency reversed in iboga-alcohol and methyl-amide particularly. Restricted locomotion was also significantly reversed in iboga-alcohol, iboga-amide, and iboga-methyl amide. Anxiolytic behaviour was obtained in the iboga-alcohol, iboga-amide and methyl-amide treated groups. Paw Substance P, CGRP, COX-2 and p65 nuclear translocation; serum IL-6 & TNF-α levels were significantly decreased in the iboga-alcohol treated group. Iboga-alcohol reversed the downregulation of GABA, Dopamine, and elevation of Substance P, NK1R and Glutamate. HRMS analysis confirmed the passage of all iboga-analogs in the brain. Iboga-analogs overturned the depleted BDNF whereas, GDNF elevation was further exaggerated. Taken together, these novel iboga-analogs, particularly iboga-alcohol, executed effective anti-nociception and prevented neuroinflammation. They warrant further clinical applications in acute pain situations.

show abstract

Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Cited by 4 publications

References 52 publications

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Traditional Kerala Ayurvedic Formulations as a Guideline for the Management of Inflammatory Bowel Disease (IBD) – A Review

Novel Iboga-derivatives Modulate Nociception and Inflammation in Acute Mouse Pain Model

Contact Info

Product

Resources

About