Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

Rhee, Sue Goo; Chae, Ho Zoon; Kim, Kanghwa

doi:10.1016/j.freeradbiomed.2005.02.026

Cited by 1,253 publications

(974 citation statements)

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“…Recent studies have shown that the sulfinic acid form of 2-cys peroxiredoxins can be reduced back to the sulfhydryl in an ATP-dependent enzyme-(sulfiredoxin, Srx) catalyzed reaction [39], and a reversible thioesterifcation has been reported to alter transcriptional activity [40], raising the possibility that additional Cys modifications may be found to have regulatory roles. Cysteines also are uniquely targeted by alkylating species (such as cyclopentenone prostaglandins, acrolein), hydroxynonenal and avicins (which can be formed endogenously, or encountered through environmental insults [41,42]), and by acylation (which has important roles in localizing proteins to the membranes [43]).…”

Section: Oxidizable Amino Acids: Reactive Cysteines As Redox Targetsmentioning

confidence: 99%

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Janssen–Heininger¹,

Mossman²,

Heintz³

et al. 2008

Free Radical Biology and Medicine

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688

646

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Section: Oxidizable Amino Acids: Reactive Cysteines As Redox Targetsmentioning

confidence: 99%

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Janssen–Heininger¹,

Mossman²,

Heintz³

et al. 2008

Free Radical Biology and Medicine

Self Cite

688

646

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“…Previous studies have indicated that PRDXs or Trx peroxidases are important endogenous antioxidants, protecting cells from oxidative damage by reducing H 2 O 2 and peroxynitrite and scavenging thiyl radicals 20, 21, 22. PRDX1 cooperates with Trx in suppressing H 2 O 2 ‐induced cell death involving different types of kinases and enzymes, such as apoptosis signal‐regulating kinase 1 (ASK1), p66 Shc and glutathione S ‐transferase pi (GSTpi)/c‐Jun NH2‐terminal kinase (JNK), which play key roles in the regulation of cell death and/or apoptosis depending on cell type and stimuli 23, 24, 25.…”

Section: Structure Functions Of Prdx1 and Its Role In Ros‐dependent mentioning

confidence: 99%

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Ding

Fan

2016

J Cellular Molecular Medi

151

116

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Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcription factors such as c‐Myc, NF‐κB and AR, and thus affects their bioactivities upon gene regulation, which in turn induces or suppresses cell death. Additionally, PRDX1 in cytoplasm has anti‐apoptotic potential through direct or indirect interactions with several ROS‐dependent (redox regulation) effectors, including ASK1, p66Shc, GSTpi/JNK and c‐Abl kinase. PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1‐regulated ROS‐dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers. In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

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“…Additionally, a predicted peroxiredoxin 6-like (spot 19) was under-expressed in overcrowding stress group at 15 days (Table 3). PRDXs are a family of antioxidant enzymes which act protecting cells from oxidative damage [61] but also show an important role in immunity since extracellular NKEF-A or PRDX1 acts as "endogenous" danger signal by binding to danger signal sensors [62]. We suggest a similar mechanism in skin mucus of gilthead seabream under overcrowding stress since NKEF showed almost 9.7 and 4.8-fold increase and also because recently, not only in gilthead seabream but also in European sea bass, it has been demonstrated nkefa and nkefb up-regulation after infection [63].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Differential proteome profile of skin mucus of gilthead seabream (Sparus aurata) after probiotic intake and/or overcrowding stress

Cordero¹,

Morcillo

Cuesta

et al. 2016

Journal of Proteomics

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Differential proteome profile of skin mucus of gilthead seabream (sparus aurata) after probiotic intake and/or overcrowding stress, Journal of Proteomics (2015Proteomics ( ), doi: 10.1016Proteomics ( /j.jprot.2015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E DM A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 AbstractGilthead seabream (Sparus aurata L.) is the major cultured fish species in the Mediterranean area. High density stocking causes stress and increases the impact of diseases leading to economic losses. Probiotics could represent a solution to prevent diseases through several mechanisms such as improving the immune status and/or mucosal microbiota or competing with pathogens. The probiotic Shewanella putrefaciens, also known as Pdp11, was firstly isolated from the skin of healthy gilthead seabream. Our study focuses on the skin mucus proteome after dietary probiotic Pdp11 intake in fish maintained under normal or overcrowding conditions. 2-DE of skin mucus followed by LC-MS/MS analysis was done for each experimental group and differentially expressed proteins were identified. The results showed differentially expressed proteins especially involved in immune processes, such as lysozyme, complement C3, natural killer cell enhancing factor and nonspecific cytotoxic cell receptor protein 1, whose transcript profiles were studied by qPCR. A consistency between lysozyme protein levels in the mucus and lysozyme mRNA levels in skin were found. Further research is necessary to unravel the implications of skin mucosal immunity on fish welfare and disease. Biological significanceThe present work reveals the proteomic changes, which are taking place in the skin mucus of stressed and non-stressed gilthead seabream after Pdp11 probiotic intake. The study contributes to improve the knowledge on skin mucosal immunology of this relevant farmed fish species.Furthermore, the paper shows for the first time how a suitable proteomic methodology, in this case 2-DE followed by LC-MS/MS is useful to perform a comparative study with a noninvasive technique of skin mucus of gilthead seabream.

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Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

Cited by 1,253 publications

References 77 publications

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Peroxiredoxin 1 – an antioxidant enzyme in cancer

Differential proteome profile of skin mucus of gilthead seabream (Sparus aurata) after probiotic intake and/or overcrowding stress

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