Male obesity and alteration in sperm parameters

Hammoud, Ahmad; Wilde, Nicole; Gibson, Mark; Parks, Anna L.; Carrell, Douglas T.; Meikle, A.W.

doi:10.1016/j.fertnstert.2007.10.011

Cited by 382 publications

(247 citation statements)

References 28 publications

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“…However, elucidating the causative chain between such factors is extremely difficult, as confounding factors are almost impossible to differentiate. Obesity, for example, is associated with increased incidence of oligozoospermia and asthenozoospermia (Jensen et al, 2004;Hammoud et al, 2008), but whether life-style factors, the age-dependent increase in visceral fat or other obesity-associated metabolic factors cause the link remains unclear.…”

Section: Paternal Age Testicular Morphology and Semen Parametersmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

285

210

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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Section: Paternal Age Testicular Morphology and Semen Parametersmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

285

210

View full text Add to dashboard Cite

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“…BMI O35 kg/m 2 ). Confusingly, Hammoud et al (2008b) initially reported that the incidence of oligo-and asthenozoospermia increased with increasing BMI, a finding seemingly contradicted by a subsequent critical review of the literature by the same group (Hammoud et al 2008a), which concluded that obesity had only a modest affect on male fertility. The latter view is supported by Aggerholm et al (2008) who found that semen quality from men with a BMI between 25 and 30 kg/m 2 was only marginally decreased if at all and by MacDonald et al (2010) who conducted a meta analysis of five published studies and concluded that there was little evidence of a relationship between BMI and semen quality.…”

Section: Introductionmentioning

confidence: 98%

Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism

Mallidis¹,

Czerwiec²,

Filippi³

et al. 2011

Reproduction

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The synergistic effect of the co-morbidities that comprise metabolic syndrome (MetS) is increasingly being recognised as an important contributor in the pathology of a broad spectrum of seemingly disparate conditions. However, in terms of male reproductive function, beyond erectile dysfunction, little is known about the influence of this cohort (collectively or separately) on spermatogenesis and sperm quality. The aims of this study were to assess the reproductive tract of a MetS animal model for detrimental changes, to determine whether a group of compounds (advanced glycation end products and their receptor) known to cause cell dysfunction and DNA damage was present and assess whether hypogonadotropic hypogonadism was the main contributing factor for the changes seen. Animals fed a high-fat diet were found to have significantly increased cholesterol, triglycerides, blood glucose, mean arterial pressure and visceral fat levels. Although serum testosterone was decreased, no changes were seen in either testicular or epididymal histology. Immunolocalisation of N 3 -carboxymethyl-lysine and the receptor for advanced glycation end products was found in the testes, epididymides and sperm of the two treated groups of animals; however, ELISA did not show any difference in protein levels. Similarly, assessment of sperm nuclear DNA (nDNA) fragmentation by acridine orange test did not find significant differences in nDNA integrity. We conclude that the minimal effect on spermatogenesis and sperm quality seen in our model is probably due to the moderate increase of blood glucose rather than the hypogonadism.

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“…Additionally, there are several illnesses of complex etiology associated with age that can affect sperm function and, a decreased semen volume and less frequent ejaculations may be related to some of the morphological and motility changes observed in sperm from elderly patients [41,53]. Furthermore, aging is related to a natural accumulation of toxic products and reproductive tract infections that may end up compromising male fertility [42].…”

Section: Sperm Parameters Decline With Agingmentioning

confidence: 99%

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

Rabaça¹,

Ferreira²

2016

Andrology(Los Angel)

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The rise in life expectancy and the desire to establish a stable career prior to parenthood leads couples to a delayed childbearing. Advanced parental age at the time of pregnancy portrays several risks, with the majority of couples above 35 experiencing reproductive impairments. While the effect of women's age on fertility is well known, the influence of paternal age is less understood. Thus, efforts have been made to comprehend the influence of APA on pregnancy upkeep and disease risk for the offspring. Over the last decades numerous studies aimed to establish the relationship between APA and male fertility potential. It has been found that APA is related to testicular and hormonal alterations, along with a decreased sperm production, quality and DNA integrity. As expected, these alterations compromise the reproductive potential of older men and have been associated with several fecundity problems, including increased time to pregnancy and abortion rates, and decreased fertilization and pregnancy rates. Additionally, alterations in offspring health, like genetic disorders, mental illnesses, congenital anomalies and cancer, have also been linked to APA. As a result, APA influence on the reproductive outcome must be taken into consideration when counseling couples attending family planning consultations or pursuing fertility treatments. Nonetheless, to date, there are still no definite results regarding this problem and an age threshold has yet not been established and additional research to better elucidate the effects of APA on fertility and offspring's health is needed. Likewise, establishing an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes.

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Male obesity and alteration in sperm parameters

Cited by 382 publications

References 28 publications

Paternal age and reproduction

Paternal age and reproduction

Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

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