Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures

Saravanan, Manoharan; Hur, Jang-Hyun; Narayanasamy, Arul; Ramesh, Mathan

doi:10.1016/j.etap.2014.10.013

Cited by 45 publications

(14 citation statements)

References 124 publications

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“…Recently many scientific communities have deviated towards the toxicity research on pharmaceuticals (Fabbri, 2015). We have already reported the impacts of few pharmaceuticals on fresh water edible fishes (Ambili et al., 2013; Saravanan et al., 2014; Ramesh et al., 2018a,b; Renuka et al., 2018). Fish farmers use unapproved chemicals to maintain the health status of fishes by preventing and treating disease outbreaks (Nyambok and Kastner, 2012).…”

Section: Discussionmentioning

confidence: 99%

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

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Labeo rohita were exposed to amoxicillin at a concentration of 1 mg/L (Treatment -I) and 0.5 mg/L (Treatment-II) for a period of 35 days. Numerous alterations were found in amoxicillin treatment groups when compared to the control group. Hemoglobin (Hb), hematocrit (Hct), and erythrocytes (RBCs) levels were significantly ( P < 0.05) decreased. Leukocytes (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were significantly ( P < 0.05) increased. In the plasma and gill tissues, ionic compounds (sodium, potassium, and chloride) levels were significantly declined throughout the treatment period. The plasma biochemical profiles were significantly altered: glucose level remained low (except at the end of 7 th day in Treatment -I) till 35 days of the treatment period. Biphasic trend occurred in the protein level, significant increase was observed on 7 th and 28 th day (Treatment -I and -II), and 35 th day (Treatment -I), and in remaining days its level was found to be decreased. Glutamate oxaloacetate transaminase (GOT) activity in the plasma was inhibited significantly, whereas in the gill, liver, and kidney tissues the enzyme activity was elevated. Plasma glutamate pyruvate transaminase (GPT) activity was inhibited throughout the study period. GPT activity in the gill was found to be elevated during the treatment period. Liver GPT activity was elevated in all the treatments except 28 th (Treatment-I) and 35 th day (Treatment-I, and II). GPT activity in the kidney was elevated (except 14 th day in Treatment-II). Lactate dehydrogenase (LDH) activity was inhibited in plasma (except 14 th day in Treatment-II), gill, liver (except 7 th day in Treatment-I), and kidney tissues significantly ( P < 0.05). The present study emphasizes that amoxicillin at 1 and 0.5 mg/L concentrations affects the hematological/biochemical/electrolytes/enzymological parameters of fish and these biomarkers serve as an effective test system for environmental risk assessment of pharmaceuticals in the aquatic environment.

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Section: Discussionmentioning

confidence: 99%

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

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“…Different responses following short-and long-term exposures to contaminants have also been recorded by several studies, in vertebrates and invertebrates. Saravanan et al (2014) reported different responses of thyroxine in carp Cirrhinus mrigala after shortand long-term exposure to diclofenac and clofibric acid. The authors showed that thyroxine level decreased only in two treatment groups exposed to clofibric acid (and not in the diclofenac groups) following short-term exposure, but longer duration of exposure decreased thyroxine levels in all concentrations of both contaminants.…”

Section: The Variation Of Mrna Expression Of Target Genes In Mussel Gonadsmentioning

confidence: 95%

Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

Koagouw

Stewart

Ciocan

2021

Environ Sci Pollut Res

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Pharmaceuticals pose a major threat to the marine environment, and several studies have recently described their negative effects on marine organisms. Pharmaceutical compounds are constantly being released into aquatic ecosystems, and chronic exposure, even at low concentrations, may have a major impact on marine organisms. The purpose of the present study is to evaluate the biological changes induced by one of the most widely used pharmaceuticals-paracetamol-in the blue mussel Mytilus edulis, after a long-term exposure at environmentally relevant concentrations. We present our data alongside and in comparison with results from a previous short-term exposure, to demonstrate the significance of exposure period on the effects of paracetamol in adult blue mussels. After 24 days of laboratory exposure, seven potential target genes were selected to examine toxicological effects in mussels' gonads and possible disruptive effects on reproductive processes. The results show the modulation of some important reproduction-related genes: estrogen receptor-2 (ER2), vitelline envelope zona pellucida domain-9 (V9), and vitellogenin (VTG). Variations in mRNA expression of four other genes involved in apoptosis (HSP70, CASP8, BCL2, and FAS) are also highlighted. Histopathological alterations caused by paracetamol, together with neutral red retention time response in mussels' hemocytes, are presented herein. Overall, this study highlights the exacerbated effects of low concentration of paracetamol after chronic exposure, similar to the damage induced by higher concentrations in a short exposure scenario, thus emphasizing the importance of length of exposure period when studying the effects of this substance. Additionally, this study also discusses the potential of paracetamol to inflict several major changes in the reproductive system of mussels and thus possibly affect the survival of populations.

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“…Simultaneously, emissions from pharmaceutical companies have also caused enormous environmental pollution. 2,3 Thus, a large amount of used antibiotics went to the soils, rivers, animals, etc. The accumulation of these residual antibiotics not only pollutes the environment, but also causes harm to human health.…”

Section: Introductionmentioning

confidence: 99%

Core–shell TiO₂@C ultralong nanotubes with enhanced adsorption of antibiotics

Wang

Hong-mei

et al. 2019

J. Mater. Chem. A

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Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures

Cited by 45 publications

References 124 publications

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

Core–shell TiO₂@C ultralong nanotubes with enhanced adsorption of antibiotics

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Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures

Cited by 45 publications

References 124 publications

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?

Core–shell TiO2@C ultralong nanotubes with enhanced adsorption of antibiotics

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Product

Resources

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Core–shell TiO₂@C ultralong nanotubes with enhanced adsorption of antibiotics