Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD)

Levels and distribution of hexabromocyclododecane (HBCD) in environmental samples near manufacturing facilities in Laizhou Bay area, East China

“…It was first detected in fish and sediment in 1998, 2 and has since been detected in various matrices including air, soil, water, sediment, fish, mammals and foodstuffs. Due to its long-range atmospheric transport potential, 3 bioaccumulation and biomagnification abilities, 4,5 neurotoxic effects and endocrine disruptive effects, 6,7 the potential risk of HBCD to the environment has been of increasing concern in recent years. In 2009, HBCD was nominated as a candidate persistent organic pollutant (POP) in the Stockholm Convention.…”

Effects of tetrabrominated diphenyl ether and hexabromocyclododecanes in single and complex exposure to hepatoma HepG2 cells

“…Neonatal exposure to HBCDs can cause developmental behavioural defects. Furthermore, HBCDs appears to be as potent as PBDEs in inducing developmental neurotoxic effects in mice (Eriksson et al, 2006). Germer et al (2006) report the effects of HBCDs on rat hepatic cytochrome P450 (CYP) levels and activities.…”

Stoffmonographie für 1,2,5,6,9,10-Hexabromcyclododecan (HBCDD) - HBM-Werte für HBCDD im Fettanteil der Muttermilch oder des Blutplasmas

“…In accordance with the EFSA Panel on Contaminants in the Food Chain [7] the HBM-Commission considered the study of Eriksson et al [128] as key study and the resulting BMDL10 as POD for the derivation of the HBM value. The available toxicokinetic data suggest that orally administered HBCDD is easily absorbed and accumulates in lipid tissue.…”