Nonmonotonic responses to low doses of xenoestrogens: A review

Xu, Zhixiang; Liu, Jun; Wu, Xiaoni; Huang, Bin; Pan, Xuejun

doi:10.1016/j.envres.2017.02.018

Cited by 57 publications

(26 citation statements)

References 78 publications

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“…The dosage and effect of EDCs seem to exhibit nonmonotonic relationships; both extremely low and high dosages can provide a maximum response, while the medium doses are associated with the concomitant absence of effect. This dosageeffect response of EDCs is often presented as a U-shaped curve, or also in the form of an inverted U-shaped curve, where medium dosing provides the maximum effect [33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Sex-dependent dysregulation of human neutrophil responses by bisphenol A

Ratajczak–Wrona

Garley

Rusak

et al. 2020

Preprint

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Background: In the present study, we aimed to investigate selected functions of human neutrophils exposed to bisphenol A (BPA) under in vitro conditions. As BPA is classified among xenoestrogens, we compared its action and effects with those of 17β-estradiol (E2).Methods: Chemotaxis of neutrophils was examined using the Boyden chamber. Their phagocytosis and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase activity were assessed via Park’s method with latex beads and Park’s test with nitroblue tetrazolium . To assess the total concentration of nitric oxide (NO), the Griess reaction was utilized. Flow cytometry was used to assess the expression of cluster of differentiation (CD) antigens. The formation of neutrophil extracellular traps (NETs) was analyzed using a microscope (IN Cell Analyzer 2200 system). Expression of the investigated proteins was determined using Western blot.Results: The analysis of results obtained for both sexes demonstrated that after exposure to BPA, the chemotactic capacity of neutrophils was reduced. In the presence of BPA, the phagocytic activity was found to be elevated in the cells obtained from women and reduced in the cells from men. Following exposure to BPA, the percentage of neutrophils with CD14 and CD284 (TLR4) expression, as well as the percentage of cells forming NETs, was increased in the cells from both sexes. The stimulatory role of BPA and E2 in the activation of NADPH oxidase was observed only in female cells. On the other hand, no influence of E2 on the expression of CD14 and CD284, chemotaxis, phagocytosis, and the amount of NET-positive neutrophils was found for both sexes. The study further showed that BPA intensified NO production and iNOS expression in the cells of both sexes. In addition, intensified expression of all tested PI3K-Akt pathway proteins was observed in male neutrophils.Conclusions: The study demonstrated the influence of BPA on neutrophil functions associated with locomotion and pathogen elimination, which in turn may disturb the immune response of these cells in both women and men. Analysis of the obtained data showed that the effect of this xenoestrogen on the human neutrophils was more pronounced than E2.

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Section: Introductionmentioning

confidence: 99%

Sex-dependent dysregulation of human neutrophil responses by bisphenol A

Ratajczak–Wrona

Garley

Rusak

et al. 2020

Preprint

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“…Controversy for the review of ACEIII (2013) , a few studies showed toxicity of low dose phthalate in male infertility and steroidogenesis ( Bloom et al, 2015 ; Savchuk et al, 2015 ). Recently it become a big issue to study the effect of very low dosage EDC with long period ( Kawaguchi et al, 2015 ; Xu et al, 2017 ). In addition, so far, it is largely masked the effects of DEHP during reproductive period.…”

Section: Introductionmentioning

confidence: 99%

Nonmonotonic Effects of Chronic Low-Dose Di(2-ethylhexyl) Phthalate on Gonadal Weight and Reproductive

Cha¹,

Jung²,

Lee³

et al. 2018

Dev Reprod

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Endocrine disruptors have been concerned in toxicology but now challenged as physiological point especially concerned with exposing dose and period. In this study the low-dose chronic administration of di(2-ethylhexyl) phthaltae (DEHP) during reproductive period was examined to evaluate the possible roles. Adult male and female CD-1 mice were exposed to DEHP with drinking water containing 133 1g/L and 1,330 /g/L DEHP in water according to OECD 433 guide line and sacrificed just after weaning. The weights of uterus and ovary were decreased by drinking of 1,330 /g/L DEHP water. There was not adverse effects on either accumulated mating rate and mating rate depend on estrus stage, pregnancy duration, and sex ration at birth. However, the accumulated rate of successful delivery and litter size were significantly high at 1,330 dg/L DEHP water. The number of epididymal sperm was significantly increased by drinking of 1,330 g/L DEHP water. In addition, the number of follicles (primary, secondary, tertiary) were more many than control at 1,330 /g/L DEHP water drunk mother. Though further studies are needed to identify what are the mechanism of DEHP in folliculogenesis and spermatogenesis. From this study we firstly report the effect of low-dose chronic administration of DEHP with drinking could change the ovarian follicle population size and spermatogenesis rate. Put together, those finding is different from previous high-dose effects and suggest the physiological role of DEHP in gonads and uterus.

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“…Recently the possible effects of low dose EDCs were continuously suggested. Low-dose NP has effects in both cell and in vivo levels ( Melnick et al, 2002 ; Xu et al, 2017 ). Yu et al (2011) explored that 100 µg/kg NP can modulate the production of progesterone in rat granulosa cells.…”

Section: Introductionmentioning

confidence: 99%

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

Cha

Baek

et al. 2017

Dev Reprod

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ABSTRACT4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both F0 and F1. In females, NP decreased the weight of ovary and uterus in F0 but not in pre-pubertal F1 pubs. Fertility of male and female in F0 or F1 was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both F0 and F1. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in F0, but significantly decreased in NP 50 group of F1. The litter size and sex ratios of offspring in F1 and F2 were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of F0 and F1 but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.

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Nonmonotonic responses to low doses of xenoestrogens: A review

Cited by 57 publications

References 78 publications

Sex-dependent dysregulation of human neutrophil responses by bisphenol A

Sex-dependent dysregulation of human neutrophil responses by bisphenol A

Nonmonotonic Effects of Chronic Low-Dose Di(2-ethylhexyl) Phthalate on Gonadal Weight and Reproductive

Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

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