Maternal and fetal/neonatal outcomes of pregnancies complicated by pulmonary hypertension: a retrospective study of 154 patients

Lv, Chengtian; Wu, Lichan; Liao, Guangyuan; Huang, Yuwen; Chen, Jingyi; Jiang, Shuyi; Chen, Dunjin; Gao, Yuanmei

doi:10.1016/j.clinsp.2023.100194

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…The imbalance between PGI 2 and thromboxane A2 causes local platelet aggregation, which may stimulate the migration and division of endomyocytes, resulting in histological changes in the MPA 9 . Factors contributing to the increased vascular impedance in the MPA include hypoxia, continuous vasoconstriction, pulmonary vascular remodeling, decreased pulmonary blood flow and thrombosis 10–12 . Eventually, the MPA in fetuses with TOF showed increased PI.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Liu,

Xu,

Zhou

et al. 2024

J of Ultrasound Medicine

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ObjectiveTo evaluate the vascular impedance of the pulmonary arteries in fetuses with tetralogy of Fallot (TOF) by Doppler echocardiography.MethodsA total of 42 fetuses with TOF (TOF group) and 84 gestational age‐matched normal fetuses (control group) were prospectively collected from the Second Xiangya Hospital of Central South University from August 2022 to January 2023. The severity of TOF was classified into mild TOF (z score ≥−2), moderate TOF (−4 < z score < −2), or severe TOF (z score ≤−4) according to the z score value of the pulmonary annulus diameter. The pulsatility index (PI) of the main pulmonary artery (MPA), distal left pulmonary artery (DLPA), and distal right pulmonary artery (DRPA) were measured by pulsed‐wave Doppler. The differences in clinical data and echocardiographic parameters between TOF group, control group, and TOF subgroups were compared.ResultsCompared with the control group, MPA‐PI increased significantly, whereas DLPA‐PI and DRPA‐PI decreased in TOF group (all P < .001). There were no significant differences in MPA‐PI and DRPA‐PI among mild TOF, moderate TOF, and severe TOF (all P > .05). However, DLPA‐PI decreased significantly in severe TOF compared with mild TOF (P < .05).ConclusionFetuses with TOF presented increased vascular impedance in the pulmonary trunk and decreased impedance in distal pulmonary artery branches. Further large and follow‐up studies are needed to demonstrate the associations between those changed vascular impedances and the development of PA in patients with TOF.

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Section: Discussionmentioning

confidence: 99%

“…9 Factors contributing to the increased vascular impedance in the MPA include hypoxia, continuous vasoconstriction, pulmonary vascular remodeling, decreased pulmonary blood flow and thrombosis. [10][11][12] Eventually, the MPA in fetuses with TOF showed increased PI.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Liu,

Xu,

Zhou

et al. 2024

J of Ultrasound Medicine

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Pulmonary hypertension

Mocumbi,

Humbert,

Saxena

et al. 2024

Nat Rev Dis Primers

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Management of pulmonary hypertension in special conditions

Preston,

Howard,

Langleben

et al. 2024

Eur Respir J

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Care of pulmonary hypertension (PH) patients in special situations requires insightful knowledge of the pathophysiology of the cardiopulmonary system and close interaction with different specialists, depending on the situation. The role of this task force was to gather knowledge about five conditions that PH patients may be faced with. These conditions are 1) perioperative care; 2) management of pregnancy; 3) medication adherence; 4) palliative care; and 5) the influence of climate on PH. Many of these aspects have not been covered by previous World Symposia on Pulmonary Hypertension. All of the above conditions are highly affected by psychological, geographical and socioeconomic factors, and share the need for adequate healthcare provision. The task force identified significant gaps in information and research in these areas. The current recommendations are based on detailed literature search and expert opinion. The task force calls for further studies and research to better understand and address the special circumstances that PH patients may encounter.

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Maternal and fetal/neonatal outcomes of pregnancies complicated by pulmonary hypertension: a retrospective study of 154 patients

Cited by 3 publications

References 20 publications

Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Assessment of Pulmonary Arterial Vascular Impedance in Fetuses With Tetralogy of Fallot

Pulmonary hypertension

Management of pulmonary hypertension in special conditions

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