Risk of osteoporotic fracture in women using the FRAX tool with and without bone mineral density score in patients followed at a tertiary outpatient clinic ‒ An observational study

Favarato, Maria Helena Sampaio; Almeida, Maria Flora de; Lichtenstein, A.; Martins, Mílton de Arruda; Ferreira, M. G. S.

doi:10.1016/j.clinsp.2022.100015

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…No DXA scans were performed routinely as the current diagnostic gold standard for verifying osteoporosis. The FRAX score was calculated without the BMD and might, therefore, be overestimated [22]. Due to the fact that patients' medical records were reviewed, a history of hip fracture in the patient's mother or father could not be assessed for calculating the FRAX score.…”

Section: Discussionmentioning

confidence: 99%

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Use of Distal Tibial Cortical Bone Thickness and FRAX Score for Further Treatment Planning in Patients with Trimalleolar Ankle Fractures

Pflüger

Harder

Müller

et al. 2023

JCM

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Trimalleolar ankle fractures show a bimodal age distribution, affecting younger men and older women. Postmenopausal women often exhibit low bone mineral density, which contributes to a higher prevalence of osteoporotic-related fractures. The primary goal of this study was to analyse the association of patient characteristics with the cortical bone thickness of the distal tibia (CBTT) in trimalleolar ankle fractures. Methods: A total of 193 patients with a trimalleolar ankle fracture treated between 2011 and 2020 were included. Patient registries were reviewed regarding demographics, mechanism, and type of injury. The CBTT was assessed in radiographs and CT images. The FRAX score was calculated to estimate the probability for an osteoporotic fracture. A multivariable regression model was calculated to identify independent variables affecting the cortical bone thickness of the distal tibia. Results: Patients older than 55 years were 4.22 (95% CI: 2.12; 8.38) times more likely to be female. In the multivariable regression analysis, female sex (β −0.508, 95% CI: −0.739; −0.278, p < 0.001) and a higher age (β −0.009, 95% CI: −0.149; −0.003, p = 0.002) were independent variables associated with a lower CBTT. Patients with a CBTT < 3.5 mm had a higher 10-year probability for a major osteoporotic fracture (12% vs. 7.75%; p = 0.001). Conclusions: The assessment of the peripheral bone quality in routine computed tomography demonstrated that higher age and female sex are significantly associated with reduced cortical bone thickness of the distal tibia. Patients with a lower CBTT showed a higher probability for a subsequent osteoporotic fracture. In female patients with reduced distal tibial bone quality and associated risk factors, an osteoporosis assessment should be evaluated.

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Section: Discussionmentioning

confidence: 99%

“…A history of hip fracture in the patient's mother or father could not be assessed and, therefore, "No" was chosen for all patients. The calculation without BMD is reliable, but the fracture risk might be overestimated [22].…”

Section: General Datamentioning

confidence: 99%