Novel angiogenic metal nanoparticles controlling intracellular gene activation in stem cells

Im, Gwang‐Bum; Lee, Jaeyoung; Song, Jiwoo; Yu, Taekyung; Bhang, Suk Ho

doi:10.1016/j.cej.2021.129487

Cited by 3 publications

(3 citation statements)

References 66 publications

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“…This can be explained because the released therapeutic ions in the Cu-ZPC extracts (Cu: 2.33 ± 0.01 ppm, Ca: 39.33 ± 0.43 ppm, Si: 10.64 ± 0.09 ppm) are much higher than that of ZPC (Cu: Not detected, Ca: 12.31 ± 0.06 ppm, Si: Not detected) based on element analysis [34,35,57]. It has been well known that the release of Cu ion results in a higher degree of cytotoxicity [60,61]. Unlike the conventional knowledge, however, our results display the opposite: the experimental group with higher cell viability.…”

Section: For Dental Materialsmentioning

confidence: 95%

Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

et al. 2022

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Section: For Dental Materialsmentioning

confidence: 95%

Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

et al. 2022

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“…In a mouse model of wound healing, the transplantation of hMSCs by these NPs resulted in considerably improved angiogenesis. Using a galvanic replacement reaction of Cu NPs and Au precursor, Gwang-BumIm et al conducted an innovative investigation, wherein they created Cu-based angiogenic metallic NPs [ 103 ]. These NPs were capable of stabilizing and upregulating intracellular activities in human adipose-derived stem cells (hADSCs).…”

Section: Factors Affecting the Behavior Of Nanomaterials On Vasculari...mentioning

confidence: 99%

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

et al. 2022

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Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed.

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“…Stem cell therapy has been widely used in wound healing through paracrine factors secreted from transplanted stem cells 1,2 While adult stem cells show low side effects (e.g., immune response due to their immunomodulatory properties) and do not raise ethical issues, 3,4 low viability of human adipose‐derived stem cells (hADSCs) caused by harsh condition of damaged tissue remains as a problem that needs to be addressed 5 . Although materials ranging from scaffolds to nanoparticles have been used to increase the therapeutic effects of stem cell therapy, 6–10 abnormal immune responses attributed to low biodegradability and long‐term side effects of these materials limit their bio‐application 11,12 . Moreover, the potential risk of carcinogenesis in the administering of stem cells is believed to be an obstacle to their uses in clinical settings 13 …”

Section: Introductionmentioning

confidence: 99%

Fortifying angiogenic efficacy of conditioned media using phototoxic‐free blue light for wound healing

Kim

et al. 2022

Bioengineering & Transla Med

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We used a blue organic light‐emitting diode (bOLED) to increase the paracrine factors secreted from human adipose‐derived stem cells (hADSCs) for producing conditioned medium (CM). Our results showed that while the bOLED irradiation promotes a mild‐dose reactive oxygen generation that enhances the angiogenic paracrine secretion of hADSCs, it does not induce phototoxicity. The bOLED enhances paracrine factors via a cell‐signaling mechanism involving hypoxia‐inducible factor 1 alpha. This study demonstrated that the CM resulting from bOLED treatment shows improved therapeutic effects on mouse wound‐healing models. This method contributes to overcoming the barriers to stem‐cell therapies, including the toxicity and low yields from other methods such as nanoparticles, synthetic polymers, and even cell‐derived vesicles.

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Novel angiogenic metal nanoparticles controlling intracellular gene activation in stem cells

Cited by 3 publications

References 66 publications

Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

Investigating the mechanophysical and biological characteristics of therapeutic dental cement incorporating copper doped bioglass nanoparticles

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

Fortifying angiogenic efficacy of conditioned media using phototoxic‐free blue light for wound healing

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