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Cited by 46 publications
(34 citation statements)
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“…Deiodinase activity is critical for regulation of tissue TH concentrations and is strongly affected by serum TH concentrations (Mol et al, 1999;Orozco and Valverde, 2005). Previous studies have shown that deiodinase activity in fish is sensitive to environmental contaminants, such as metals, polychlorinated biphenyls and pesticides (Cyr et al, 1988;Brown et al, 2004;Coimbra et al, 2005;Li et al, 2009), and they have recommended including a measure of deiodination gene expressions as sensitive biomarkers of thyroid disruption in fish upon exposure to environmental chemicals (Picard-Aitken et al, 2007;Li et al, 2009). In the present study, we found a significant increase in Dio1 gene expression, but no significant effects on Dio2 gene expression.…”
Section: Discussionmentioning
confidence: 99%
“…Deiodinase activity is critical for regulation of tissue TH concentrations and is strongly affected by serum TH concentrations (Mol et al, 1999;Orozco and Valverde, 2005). Previous studies have shown that deiodinase activity in fish is sensitive to environmental contaminants, such as metals, polychlorinated biphenyls and pesticides (Cyr et al, 1988;Brown et al, 2004;Coimbra et al, 2005;Li et al, 2009), and they have recommended including a measure of deiodination gene expressions as sensitive biomarkers of thyroid disruption in fish upon exposure to environmental chemicals (Picard-Aitken et al, 2007;Li et al, 2009). In the present study, we found a significant increase in Dio1 gene expression, but no significant effects on Dio2 gene expression.…”
Section: Discussionmentioning
confidence: 99%
“…Namely, a second coat of oil was sprayed on the feed pellets and uneaten feed and faeces were routinely removed from the tanks. On the other hand, no precautions to limit the exposure to endosulfan through the water were taken in the Nile tilapia studies (Coimbra et al, 2005(Coimbra et al, , 2007, suggesting that this pathway could be responsible for the observed effects. However, this hypothesis can neither be confirmed nor ruled out since endosulfan concentrations in water were not monitored in the studies in Nile tilapia.…”
Section: Comparison Of Study Results and Applied Exposure Conditionsmentioning
confidence: 99%
“…At the time of the opinion revision, only two papers on dietary toxicity were available and they reported effects that were considered 'subtle, possibly adaptive and not considered to represent adverse effects'. In particular, effects on thyroid hormone metabolism were observed in Nile tilapia exposed to a dietary concentration of 0.1 mg/kg of endosulfan (Coimbra et al, 2005), and ultra structural alterations of the liver and the gut were observed in common carp at a dietary concentration of 0.0005 mg/kg (Braunbeck and Appelbaum, 1999). A specific recommendation was made by the CONTAM Panel to perform studies on oral toxicity in fish.…”
Section: Introductionmentioning
confidence: 99%
“…In a recently published study on Nile tilapia of about 140 g b.w., the effects of endosulfan at 100 and 500 µg/kg diet during 21 or 35 days exposure on thyroid hormone levels and metabolism were investigated (Coimbra et al, 2005). The plasma levels of T4 and of the inactive metabolite reverse T3 were decreased compared to levels in control fish, the effect was most prominent at the lowest dose.…”
Section: Fishmentioning
confidence: 99%