Adsorption of polyethylene glycol (PEG) onto cellulose nano-crystals to improve its dispersity

Dong, Chen; Wen, Yangbing; Wang, Lijuan; An, Xingye; Zhu, Xuhai; Ni, Yonghao

doi:10.1016/j.carbpol.2015.01.035

Cited by 117 publications

(51 citation statements)

References 29 publications

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“…This type of assembly is instead typical of pure CN, where inter-fibrils hydrogen bonding is predominant, resulting in the formation of a considerable quantity of carbonaceous residue after thermal degradation in nitrogen atmosphere. Similar results were obtained by Cheng et al, that considered the addition of PEG 1000 to cellulose nanofibrils [49].…”

Section: Resultssupporting

confidence: 88%

Chitin Nanofibrils in Poly(Lactic Acid) (PLA) Nanocomposites: Dispersion and Thermo-Mechanical Properties

Coltelli

Cinelli

Gigante

et al. 2019

IJMS

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Chitin-nanofibrils are obtained in water suspension at low concentration, as nanoparticles normally are, to avoid their aggregation. The addition of the fibrils in molten PLA during extrusion is thus difficult and disadvantageous. In the present paper, the use of poly(ethylene glycol) (PEG) is proposed to prepare a solid pre-composite by water evaporation. The pre-composite is then added to PLA in the extruder to obtain transparent nanocomposites. The amount of PEG and chitin nanofibrils was varied in the nanocomposites to compare the reinforcement due to nanofibrils and plasticization due to the presence of PEG, as well as for extrapolating, where possible, the properties of reinforcement due to chitin nanofibrils exclusively. Thermal and morphological properties of nanocomposites were also investigated. This study concluded that chitin nanofibrils, added as reinforcing filler up to 12% by weight, do not alter the properties of the PLA based material; hence, this additive can be used in bioplastic items mainly exploiting its intrinsic anti-microbial and skin regenerating properties.

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Section: Resultssupporting

confidence: 88%

Chitin Nanofibrils in Poly(Lactic Acid) (PLA) Nanocomposites: Dispersion and Thermo-Mechanical Properties

Coltelli

Cinelli

Gigante

et al. 2019

IJMS

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“…As a PVP molecule contains a strongly hydrophilic pyrrolidone moiety and a considerable hydrophobic alkyl group, adsorbed PVP can prevent aggregation of nanoparticles through repulsive forces which arise from the hydrophobic carbon chains. PVP can provide a steric hindrance that will allow the dried PVP/CNC to be readily redispersed in aqueous systems [27,67,68].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Polyvinylpyrrolidone/Cellulose Nanocrystals Composites

et al. 2018

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Composite films and aerogels of polyvinylpyrrolidone/cellulose nanocrystals (PVP/CNC) were prepared by solution casting and freeze-drying, respectively. Investigations into the PVP/CNC composite films and aerogels over a wide composition range were conducted. Thermal stability, morphology, and the resulting reinforcing effect on the PVP matrix were explored. FTIR, TGA, DSC, X-ray diffraction, SEM, and tensile testing were used to examine the properties of the composites. It was revealed PVP-assisted CNC self-assembly that produces uniform CNC aggregates with a high aspect ratio (length/width). A possible model of the PVP-assisted CNC self-assembly has been considered. Dispersibility of the composite aerogels in water and some organic solvents was studied. It was shown that dispersing the composite aerogels in water resulted in stable colloidal suspensions. CNC particles size in the redispersed aqueous suspensions was near similar to the CNC particles size in never-dried CNC aqueous suspensions.

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“…In other word, the DM method overestimated the release kinetic of the nanoparticles once again, probably because of the extra damage to the nanoparticles. Previous studies found that cellulose could interact with PEG so that the nanoparticles within the dialysis membrane tended to accumulate to the surface of the dialysis membrane gradually during the release study, causing particle aggregation and subsequent destabilization ( Figure 8 B) [ 39 , 40 ]. As a result, the VitD3 nanoparticles in the donor compartment became unstable after 3 h with a PDI > 0.3, and more VitD3 was released to the receiver compartment ( Table S1 ).…”

Section: Resultsmentioning

confidence: 99%

In Vitro Release Study of the Polymeric Drug Nanoparticles: Development and Validation of a Novel Method

2020

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The in vitro release study is a critical test to assess the safety, efficacy, and quality of nanoparticle-based drug delivery systems, but there is no compendial or regulatory standard. The variety of testing methods makes direct comparison among different systems difficult. We herein proposed a novel sample and separate (SS) method by combining the United States Pharmacopeia (USP) apparatus II (paddle) with well-validated centrifugal ultrafiltration (CU) technique that efficiently separated the free drug from nanoparticles. Polymeric drug nanoparticles were prepared by using a four-stream multi-inlet vortex mixer with d-α-tocopheryl polyethylene glycol 1000 succinate as a stabilizer. Itraconazole, cholecalciferol, and flurbiprofen were selected to produce three different nanoparticles with particle size <100 nm. By comparing with the dialysis membrane (DM) method and the SS methods using syringe filters, this novel SS + CU technique was considered the most appropriate in terms of the accuracy and repeatability to provide the in vitro release kinetics of nanoparticles. Interestingly, the DM method appeared to misestimate the release kinetics of nanoparticles through separate mechanisms. This work offers a superior analytical technique for studying in vitro drug release from polymeric nanoparticles, which could benefit the future development of in vitro-in vivo correlation of polymeric nanoparticles.

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Adsorption of polyethylene glycol (PEG) onto cellulose nano-crystals to improve its dispersity

Cited by 117 publications

References 29 publications

Chitin Nanofibrils in Poly(Lactic Acid) (PLA) Nanocomposites: Dispersion and Thermo-Mechanical Properties

Chitin Nanofibrils in Poly(Lactic Acid) (PLA) Nanocomposites: Dispersion and Thermo-Mechanical Properties

Preparation and Characterization of Polyvinylpyrrolidone/Cellulose Nanocrystals Composites

In Vitro Release Study of the Polymeric Drug Nanoparticles: Development and Validation of a Novel Method

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