Polyelectrolyte complexes of gum kondagogu and chitosan, as diclofenac carriers

Naidu, V.G.M.; Madhusudhana, K.; Sashidhar, R.B.; Sistla, Ramakrishna; Khar, Roop K.; Ahmed, Farhan; Diwan, Prakash V.

doi:10.1016/j.carbpol.2008.11.010

Cited by 95 publications

(51 citation statements)

References 25 publications

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“…Besides, in acidic medium, protonation of the amine groups of chitosan and presence of negative charges of polyanion (TPP) cause tightening of the network in the nanoparticle system. This effect results in less swelling thus retardation of drug release (25,29,30). Our findings are in line with the study of Naidu et al (29) who reported that water uptake of diclofenac-loaded polyelectrolyte complex of chitosan and gum Kondagogu was maximal at pH 6.8 (0.1 phosphate buffer) when compared to acidic solution.…”

Section: Discussionsupporting

confidence: 92%

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Kouchak

Azarpanah

2015

Jundishapur J Nat Pharm Prod

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Background: Chitosan-based nanoparticle systems have gained wide interest, mainly for their biocompatibility, biodegradability and mucoadhesive properties. Objectives: The aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. Materials and Methods: Chitosan (CS) nanoparticles containing diclofenac was prepared using the ionotropic gelation method. Sodium tripolyphosphate (TPP) was used as a polyanion in this process. The effect of some parameters on particle size and drug loading efficiency was evaluated. Results: Transmission electron microscopy (TEM) photographs exhibited typical spherical shape of particles. The mean particle size was within 129 -166 nm and was affected by homogenization, CS/TPP ratio, CS/drug ratio and pH of medium. The maximum drug loading efficiency was estimated as 65.43 ± 7.03% with CS/drug ratio of 10:1. This value tended to decrease by enhancement of drug proportion in the formulations. Differential scanning calorimetry data confirmed the formation of polyelectrolyte complex of TPP and chitosan. Drug release profile in phosphate buffer solutions (pH 6.8, 7.4) showed initial burst effect followed by a slower release pattern. However, release of diclofenac in the acidic medium was negligible. Conclusions: Diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac.

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Section: Discussionsupporting

confidence: 92%

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Kouchak

Azarpanah

2015

Jundishapur J Nat Pharm Prod

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“…− functional groups of polysaccharides with the -NH3 + groups of ionized CH molecule could result in the alteration of film forming capability and drug release regulation property [11]. Based on the phenomena, -COO groups present in galacturonic acid of OFG could be interacted with -NH3 + groups present in CH molecules.…”

Section: The Interactions Of -Coomentioning

confidence: 99%

“…The researchers have worked to enhance the film forming property of various polysaccharides such as chondroitin [8], sodium citrate [9], sodium alginate [10], and co-processing with CH. The drug delivery in colorectal drug release dosage forms [11], sustained release drug delivery systems [12] and transdermal film formulations [7], has been improved through these films.…”

Section: Introductionmentioning

confidence: 99%

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

Nagpal

Aggarwal

Jain

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research is aimed at formulation and evaluation of okra fruit gum (OFG)-chitosan (CH) impregnated polymer network films. Methods:The film forming property of the gum attained from fruits of Abelmoschus esculentus was enhanced by co-processing it with CH. Estimation of properties including swelling index (SI), film volume, volume index, film surface contact angle with buffer solutions (pH 1.2, 7.4 or 6.8), work of adhesion (Wa), and spreading coefficient was done. Results:The contact angle and SI of OFG-CH film in both acidic and alkaline buffers were witnessed to be lowest when equated with the films prepared with difference in ratios of both gum and CH. Moreover, the Wa and spreading coefficient were less for this film. These results could be attributed to the optimum interaction between -COO − groups of gum and -NH3 + groups of CH. Conclusion:The actual nature of the film found to be tough, flexible, and water resistant. Hence, the results have shown that the films produced have a high potential for use in modified drug release and in food and pharmaceuticals.

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“…Even though gum karaya, also known as Indian tragacanth, and KG are classified in the same group, there are considerable differences in their physical and chemical properties [101,102]. Extensive research has been carried out on KG (Cochlospermum gossypium), a gum extracted from kondagogu tree, which grows in India, including its morphological, physical and chemical, structural, rheological, pharmaceutical emulsifying properties and its toxicological evaluation as a food additive [79,80,[102][103][104][105][106][107]. Furthermore, this gum can also be used as a biosorbent for the removal of toxic metal contaminants from aqueous environments and also as an environmental friendly material for the stabilization and a reducing agent for the synthesis of metal/metal oxide nanoparticles [108][109][110][111][112].…”

Section: Tree Gums -An Overviewmentioning

confidence: 99%

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

Padil

Černík

2016

Ecological Chemistry and Engineering S

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Abstract:The recent advances and potential applications of nanoparticles and nanofibres for energy, water, food, biotechnology, the environment, and medicine have immensely conversed. The present review describes a 'green' method for the synthesis and stabilization of nanoparticles and 'green electrospinning' both using tree gums (arabic, tragacanth, karaya and kondagogu). Furthermore, this review focuses on the impending applications of both gum stabilized nanoparticles and functionalized membranes in remediation of toxic metals, radioactive effluents, and the adsorptive removal of nanoparticulates from aqueous environments as well as from industrial effluents. Besides, the antibacterial properties of gum derivatives, gum stabilized nanoparticles, and functionalized electrospun nanofibrous membranes will also be highlighted. The functionalities of nanofibrous membranes that can be enhanced by various plasma treatments (oxygen and methane, respectively) will also be emphasized.

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Polyelectrolyte complexes of gum kondagogu and chitosan, as diclofenac carriers

Cited by 95 publications

References 25 publications

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Preparation and In Vitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

Green Synthesis: Nanoparticles and Nanofibres Based on Tree Gums for Environmental Applications

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