Oxazolones: New tyrosinase inhibitors; synthesis and their structure–activity relationships

Non-Traditional Pesticidally Active Compounds

“…Regarding the prepared oxazolones, compound 5 appeared more effective than compound 4 against the tested fungi and larvae. This difference between oxazolone derivatives could be due to the substituted moiety on C-2 position [45] as they revealed that substitution of functional group (s) at C-4 and C-2 positions plays a vital role in oxazolone series activity. They also revealed that oxazolone derivatives demonstrated excellent in vitro tyrosinase inhibitory.…”

Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones

“…General procedure for the synthesis of compounds 1-29 A mixture of differently substituted E-oxazolones [22][23][24] (1 mmol) and substituted aromatic amines (1.1 mmol) in anhydrous pyridine were irradiated by microwaves (CEM Discover system, model 908010) for 10-15 min at 150°C. The input power of the microwave reactor was 300 W, and the same power was used for all reactions.…”

“…In our ongoing research on leishmaniasis [17][18][19][20] , we synthesized 29 imidazolones, 1-29, by treating different oxazolones with varyingly substituted aromatic amines. In a typical reaction, a mixture of differently substituted E-oxazolones [21][22][23] (1 mmol) and substituted aromatic amines (1.1 mmol) in anhydrous pyridine were irradiated by microwaves to afford compounds 1-29. Compounds 1-29 were randomly screened for their in vitro anti-leishmanial potential.…”

Spectroscopic, Structural and Density Functional Theory (DFT) Studies of Two Oxazol-5-one Derivatives

“…[1][2][3][4][5] Due to the five -membered heterocyclic core, oxazol-5-ones are biologically active molecules and widely used in biomedicinal applications. [6][7][8][9] Oxazol-5-ones have found important roles as drugs, enzyme inhibitors and fluorescent sensors. [7][8][9][10] Oxazol-5-ones are also used in dye industry owing to the fact that oxazol-5-ones are easily obtainable in crystalline states and they possess promising photochemical/photophysical properties due to their chromophore group.…”

“…[6][7][8][9] Oxazol-5-ones have found important roles as drugs, enzyme inhibitors and fluorescent sensors. [7][8][9][10] Oxazol-5-ones are also used in dye industry owing to the fact that oxazol-5-ones are easily obtainable in crystalline states and they possess promising photochemical/photophysical properties due to their chromophore group. 10,11 Herein, we report on the synthesis, spectral characterization and theoretical studies of two oxazol-5-one derivatives.…”